Parasitic diseases usually cause patients a lot of trouble. However, it is not always possible to choose such effective Anthelmintics, which would fit any patient. Therefore, doctors often in the treatment of helminthiasis administered Nematol – is a broad spectrum of exposure.
Description
The basis of the preparation is a compound albendazole, belonging to the chemical group of carbonatesilicate. This substance is effective against both tapeworms and round.
It affects the intestinal tract of worms and muscle tissue, blocking passing in them biochemical processes. Also, the drug inhibits the formation of eggs and larvae of helminths. In the result, the worms die and are excreted from the body in a natural way. The drug can impact not only on adult worms and their larvae.
Albendazole acts on different types of parasites. But the most sensitive to its effects tapeworm, Giardia, cestodes and nematodes, above all, their larval forms. Albendazole may impact on the parasites that live in the gut and tissue parasites affecting other organs.
Albendazole is a relatively safe drug. He has a gentle action on the liver and kidneys. Therefore, it is often used for the treatment of children whose bodies affected by worms. It is no secret that kids are at increased risk in relation to helminth invasion. This is not surprising because small children are still not trained to carefully observe the rules of hygiene, and the desire for intense knowledge of the world encourages them to play in the soil, pick up dirty things in the street.
Here must be added the fact that the majority of preschool children closely communicate with each other in kindergartens, which increases the chances of transmission of helminths in mutual contacts.
Nematol is well suited for use in Pediatrics. With this in mind, especially for children developers of the drug was created a special form of medication – chewable tablets. In addition, for the youngest children it is recommended to apply the suspension. Nematol for prevention should only be given to children under the age of five. Although, of course, these types of the drug can be used in older patients, especially because the dosage of albendazole for children and adults alike.
Pharmacodynamics
Drug bioavailability is relatively low (30 %), however it increases sharply at the use of the drug simultaneously with food, especially fat. For this reason, the drug should be taken during meals. The time to reach maximum concentration in the blood – 2-5 PM Albendazole is metabolized in the liver, and one of its metabolites, albendazole sulfoxide is also capable of destroying parasites. Time poluvyvod – 8-12 hours With impaired kidney function withdrawal times of the drug is not changed. Albendazole accelerates metabolism of certain drugs.
Testimony
The drug is used to treat various helminth infestations and protozoal infections:
- ascariasis;
- enterobiasis;
- hookworm disease;
- necatoroz;
- trihozefalez;
- hydatid cyst of the liver, lung or peritoneum;
- nematodes;
- giardiasis;
- neurocysticercosis;
- toxocariasis;
- strongyloidiasis.
In some cases, the drug can be used Nematol for the prevention of helminth infection. Tool is used for the treatment of mixed infestations.
Release form
Nematol sold in three versions. First of all, this pill. Pills can have dose of 200 and 400 mg Also sells chewable tablets 400 mg and suspension 100 mg/5 ml in vials of 20 ml.
Usage instructions
How to take Nematol adults and children? The standard dosage for adults and children from 2 years – 400 mg tablets or 20 ml suspension once a day. The maximum daily dose for adults is 800 mg (40 ml). Dosage and duration of therapy may vary depending on the disease.
When neurocysticercosis and echinococcosis requires 400 mg (20 ml) twice a day. However, this dosage is permitted only for patients with body weight above 60 kg. otherwise, the daily dose is calculated on the basis of weight – 15 mg/kg. It must also be distributed on two installments.
The duration of therapy of neurocysticercosis with Nemasole ranges from 8 to 30 days depending on the severity of the body. Treatment of neurocysticercosis should be accompanied by intake of corticosteroids (to prevent seizures hypertension) and anticonvulsants.
When echinococcosis treatment longer and consists of three cycles of 4 weeks with 2 week break between them.
When a rubella all adults and children over 14 years old who weigh more than 60 kg is prescribed 400 mg (20 ml) of the drug 2 times a day. Adults and children weighing less than 60 kg should receive 200 mg (10 ml) twice a day. Children under 14 years old should take the drug at the rate of 10 mg/kg. This dose should be divided into two doses per day. The duration of treatment is 1-2 weeks.
In mixed infestations duration of treatment is usually 8 days. The doctor this time can be increased.
As stated in the instructions for use, swallow the tablets is recommended during the meal – this greatly increases the efficacy and reduces the likelihood of side effects.
Other instructions
If a family has one sick bot, and other family members should take the drug as a preventive measure.
Prolonged treatment is recommended every 2 weeks for tests that can identify changes in the composition of the blood. With the advent of radiation therapy with the drug should be discontinued except in those cases when the decrease in white blood cells is conservative and not progressive.
Overdose is usually expressed in increased severity of side effects, especially changes in blood pressure and deterioration of the liver. In case of overdose it is recommended gastric lavage, reception of enterosorbents and symptomatic therapy.
After finishing the prescribed course, the patient should take the tests to check if he is freed from parasites. If treatment is not effective, you may be assigned a second course.
Significant drug interactions with other drugs is not fixed. Dexamethasone and zimetidin increase the concentration of albendazole sulfoxide in the blood.
Contraindications
In the application it is noted that the drug is not approved for use during breastfeeding and pregnancy. Although albendazole has teratogenic effects, i.e., does not affect the formation of the fetus, it can cause serious deviations in the normal process of childbearing. In exceptional cases, physicians may prescribe the drug in the second or third trimester, however, only as therapeutic and not prophylactic.
In addition, before you start treatment with the drug, the woman should check if she was pregnant. This is because the course of drug treatment can be lengthy and in case of a natural continuation of pregnancy, the medicine may affect it.
Also, the drug should not be given to children under 2 years. Prohibited means and in diseases of the retina. With caution taking the drug for violations of liver function, diseases of the hematopoietic system, severe somatic diseases. Renal failure is not a reason to ban the drug. In diseases of the liver should regularly monitor the main biochemical parameters of the liver.
The product is not compatible with alcohol, so at the time of treatment should abandon alcohol.
The application of chelators or antacids efficacy of the drug will be significantly reduced. Therefore, the interval between doses nemasole and drugs of these classes must be at least 4 hours.
Side effects
Most often when taking the drug experience an allergic reactions such as skin rash.
It is also possible disorders of the gastrointestinal tract (nausea, abdominal pain, vomiting), increased blood pressure and body temperature, violation of the liver (increase of transaminases) and kidney.
Relatively rarely, patients taking the drug may face the disorders of the blood:
- leukopenia,
- a granulocytopenia,
- thrombocytopenia,
- the agranulocytosis,
- pancytopenia.
More often, there may be side effects like dizziness and headaches. The latter circumstance is the reason that the drug is not recommended for people controlling the vehicles and perform work requiring concentration.
Most of the side effects (such as allergic reactions or headaches) are held a few days later and the drug is not required. If not, you should consult the doctor and he will decide whether to change the dose or replace the drug with another.
