Concurrent JAK2 mutation and isolated del(5q) associated with marrow fibrosis and small hypo/monolobated megakaryocytes
A 68-year-old woman of Asian descent presented with fatigue and anemia requiring blood transfusion. There …
Category: Hematology
T-cell prolymphocytic leukemia negative for surface CD3 and CD45
A 75-year-old man was referred to us with an outside diagnosis of T-cell prolymphocytic leukemia …
The antiphospholipid syndrome finally fathomed?
Molecular basis of the activation of endothelial cells by anti–β2 glycoprotein I antibodies. This scheme …
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis
Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia …
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
Ring sideroblasts characterize a group of myelodysplastic syndrome (MDS) first described in 1956 by Bjorkman.1 …
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
Calreticulin mutants responsible for myeloproliferative neoplasms specifically activate the thrombopoietin receptor and in turn JAK2. …
Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL
The study design has been reported previously.2 In short, the CLL8 trial was a prospective, …
International phase 3 study of azacitidine vs conventional care regimens in older patients with newly diagnosed AML
Azacitidine increased median overall survival by 3.8 months vs current commonly used AML treatments (10.4 …
Platelet satellitism around cytoplasmic fragments of neoplastic lymphocytes
An 84-year-old woman presented to our institution with chest discomfort, dyspnea, and lower-extremity edema. She …
HHV8-associated lymphoproliferative disorder in the peripheral blood
A 50-year-old African man with well-controlled HIV infection presented with constitutional symptoms, progressive multiorgan failure, …
Visceral leishmaniasis presenting with pancytopenia and circulating blastlike lymphocytes
A previously healthy 3-year-old Syrian boy presented with fever and pancytopenia with 6% circulating lymphoblastlike …
Cryoglobulin-induced red blood cell morphologic changes
A 52-year-old man with untreated hepatitis C presented to the hospital with cough and shortness …
Double-expressor intravascular large B-cell lymphoma involving the female genital tract
A 43-year-old woman was admitted with chronic pelvic pain and unexplained fever. Her laboratory findings …
How I safely transfuse patients with sickle-cell disease
A 35-year-old woman presented for cardiac surgery with a history of 2 prior DHTRs at …
How I treat the postthrombotic syndrome
The postthrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) that imposes …