Internuclear bridging outside of primary myelodysplasia and congenital dyserythropoietic anemia
A 53-year-old man with no history of anemia or macrocytosis was newly diagnosed with HIV …
Category: Hematology
Utility of baseline 18FDG-PET/CT functional parameters
The International Extranodal Lymphoma Study Group (IELSG) 26 study was designed to evaluate the role …
A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation
Maintenance of the blood system requires balanced cell fate decisions by hematopoietic stem and progenitor …
Modeling of stable isotope labeling data supports short blood neutrophil half-lives
Human neutrophils have traditionally been thought to have a short half-life in blood; estimates vary …
Clinical efficacy and management of monoclonal antibodies targeting CD38 and SLAMF7 in multiple myeloma
Immunotherapeutic strategies are emerging as promising therapeutic approaches in multiple myeloma (MM), with several monoclonal …
Rap1 and its effector RIAM are required for lymphocyte trafficking
Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid …
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms
We conducted a genome-wide association study (GWAS) to identify novel predisposition alleles associated with Philadelphia …
Activating mutations in genes related to TCR signaling in angioimmunoblastic
Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a …
A phase 2 study of idelalisib plus rituximab in treatment-naive older patients with chronic lymphocytic leukemia
Idelalisib is a first-in-class oral inhibitor of PI3Kδ that has shown substantial activity in patients …
Hypermorphic mutation of phospholipase C, CLL confers BTK independency upon B-cell receptor activation
Ibrutinib has significantly improved the outcome of patients with relapsed chronic lymphocytic leukemia (CLL). Recent …
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia
Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic leukemia (CLL). The acquisition …
PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development
Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint augments antitumor …
Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
IL-17–producing cells are important mediators of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). …
Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis
Exome sequencing and novel variant identification Whole-exome sequencing data were aligned to the human genome …
Molecular prediction of durable remission after first-line in chronic lymphocytic leukemia
Fludarabine, cyclophosphamide, and rituximab (FCR) has represented a significant treatment advancement in chronic lymphocytic leukemia …