Loratadin and Desloratadine, drug choice

These antihistamines are similar in many ways, but they also have significant differences. If you need to stop the condition of an allergy in a child, then it is better to choose loratadine. Persons with kidney failure should also give preference to this remedy. Loratadine is better perceived by the body and less likely to cause side effects.

For the treatment of idiopathic chronic urticaria, desloratadine is recommended. With pseudo-allergic reactions, dermatoses, it is better to buy loratadine. If loratadine gives insufficient clinical effect, then desloratadine should be taken (this drug is considered more powerful).

If there are financial problems and you need to save on treatment, then it is better to buy loratadine. In the pharmacies of the country, this medicine is sold at a lower cost.

An optimal drug can be selected by a competent doctor. Therefore, it is better to find out from the attending physician which medication is more suitable for the treatment of an existing pathological condition.

Antihistamines are used to treat allergies. Popular are loratadine and desloratadine. The difference between these drugs, at first glance, is insignificant. Therefore, often among allergy sufferers the question arises of which medicine to give preference to. To give an answer to it, you should consider the description of each medication.


Available in white tablets with a flat and chamfered shape. The therapeutic effect is achieved due to the presence of the substance loratadine. In tablets, this component is present in a dosage of 10 mg. Of the auxiliary elements there are primellose, calcium stearate, potato starch, milk sugar.


The mechanism of action is based on the blocking of H1-histamine receptors. The drug inhibits the release of leukotriene C-4 and histamine from mast cells. The antiallergic effect occurs half an hour after taking the drug. The medicine is effective during the day.

The manufacturer recommends the use of tablets in such cases:

  • Itchy skin of unknown etiology.
  • Allergy to an insect bite.
  • Allergic dermatosis.
  • Quincke’s edema.
  • Allergic conjunctivitis, rhinitis.
  • Hives.
  • Pseudo-allergic reaction.

It is necessary to refuse treatment with this tool in such cases:

  1. Bearing a child.
  2. Intolerance to the composition.
  3. Age younger than three years.

With caution, you need to drink tablets with renal failure.

Children 3-12 years old should drink the medicine in a daily dose of 5 mg. Adults are prescribed 10 mg of the active substance per day. Against the background of therapy, such unwanted symptoms are possible:

  • Dry mouth.
  • Alopecia.
  • Headache.
  • Rash.
  • Gastritis.
  • Weakness.
  • Nausea.
  • Drowsiness.

A package of medicine, consisting of 10 tablets, costs about 50-55 rubles.


Available in round biconvex tablets. The product is coated with a blue film coating. Each tablet contains 5 mg of desloratadine (this element is the primary active metabolite of loratadine). This substance has a therapeutic effect. Additionally, the preparation contains hypromellose, zinc stearate, pregelatinized starch, cellulose, magnesium oxide and lactose.


The drug blocks the activity of H1-histamine peripheral receptors. It inhibits a number of allergic inflammation reactions. The antihistamine effect occurs half an hour after taking the pill and lasts a day.

A medicine is prescribed in such cases:

  • Allergic seasonal rhinitis.
  • Idiopathic urticaria of a chronic type.

The medication is strictly prohibited in the presence of such conditions:

  1. Breast-feeding.
  2. Age to 12 years.
  3. Lactase deficiency.
  4. Allergy to desloratadine.
  5. Glucose-galactose malabsorption.
  6. Pregnancy.

With caution, a medication is prescribed for renal failure. Tablets are taken once a day, one at a time. Against the background of treatment, such side effects are possible:

  • Allergic manifestations.
  • Cramps.
  • Arrhythmia.
  • Headache.
  • Drowsiness.
  • Dyspnoea.
  • Hallucinations.
  • Insomnia.
  • Myalgia.
  • Bowel disorder.
  • Dry mouth.
  • Hepatitis.

A package of 10 tablets of desloratadine costs about 90-100 rubles.

Comparative characteristic: general points

Common features of drugs:

  • Used to treat allergic conditions.
  • Available in tablet form.
  • Their effect persists for a day.
  • Contraindicated in pregnant women and those who are diagnosed with renal failure.
  • They have the same reception scheme.
  • Good help, according to patients and doctors.
Comparative characteristic: distinctive features

Despite the presence of a considerable number of common features, loratadine and desloratadine have certain differences.

The main distinguishing features of the funds under consideration:

  1. Contain various active ingredients.
  2. Desloratadine is contraindicated in children under 12 years of age, and loratadine can be taken from the age of three.
  3. Desloratadine has more contraindications. It often causes side effects.
  4. Loratadine treatment is cheaper.
  5. Loratadin has a wider list of indications.
  6. Desloratadine has a stronger effect on the body.

Leave a Reply

Your email address will not be published. Required fields are marked *