21.04.2024

Nifedipine and Kapoten, the choice of drug

Both drugs significantly affect the vessels, expanding them, which leads to a decrease in blood pressure. They are used in the treatment of circulatory system diseases.

Medicines are rapidly and almost completely absorbed in the digestive tract. To remove from the body, the main burden falls on the kidneys.

Both drugs have many contraindications and side effects. Both are taken strictly in certain doses, as they can lead to undesirable consequences.

For the treatment of vascular diseases that cause arterial hypertension, ischemia, angina pectoris, Nifedipine and Kapoten are used.

What are the advantages and disadvantages of each drug can be understood after a detailed examination of each separately.

Nifedipine

The drug is made in the form of tablets in a shell. 30 tablets (10 mg), 50 tablets (10, 20 mg) per pack.

The therapeutic effect is due to the active substance – nifedipine.

Nifedipine

The drug is a calcium channel blocker. Due to this property, an antianginal and hypotensive effect is carried out. There is a decrease in tension of the smooth muscles of the tubular formations, expansion in the arteries. The resistance of peripheral vessels decreases, blood pressure drops.

It is proved that with prolonged treatment with the drug, atherosclerotic plaques cease to form in the coronary vessels.

In the early days of treatment, it can cause tachycardia. The drug intensified affects the excretion of sodium and water from the body.

Patients with Rhine syndrome may experience a decrease in vasospasm of the limbs. In individuals with neurogenic hypertension, the progression of the syndrome of impaired renal function is slowed down.

The use of the drug in the complex treatment of the syndrome caused by decompensated myocardial dysfunction (chronic stage) leads to an improvement in the functioning of the heart muscle. Its size is significantly reduced.

The dosage is selected individually, depending on the degree of the disease. In order to avoid irritation of the gastrointestinal mucosa, Nifedipine is used with or after meals. The usual dose is 1 tablet up to 3 times. In some cases, 2 tablets up to 2 times. The maximum dose should be no more than 40 mg.

Dosage is required to be adjusted for elderly patients, those who are undergoing treatment for liver failure, patients whose cerebral circulation is impaired (severe form).

If the dose is exceeded, the following symptoms may appear: lowering blood pressure, hyperemia of the skin, bouts of headache, bradycardia.

Sometimes these symptoms act as side effects. They are joined: dizziness, nausea, tachycardia, swelling on the legs.

Shelf life up to 3 years.

Kapoten

Available in tablet form (25 or 50 mg). The manufacturer determines the shape and appearance of the tablets.

The main active substance is captopril, which performs the expansion of lumens in blood vessels and reduces blood pressure.

Kapoten

The medicinal product is classified as an ACE inhibere. Its effect prevents the formation of angiotensin || By this, the gaps in the arteries and veins increase, and the pressure drops.

The therapeutic effect occurs after an hour. 75% of the substance is absorbed. It is excreted by the urinary system. Patients with elevated levels of urea and creatinine need to consult a physician.

Dosage is determined individually, depending on blood pressure and disease symptoms. The main thing is not to exceed 150 mg per day. The time of admission is independent of food intake.

Kapoten can harm in case of hypersensitivity to captopril, ACE inhibitors, people with a hereditary predisposition to Quincke’s edema, with liver and kidney dysfunctions.

The drug is not prescribed for pregnant and lactating.

There is a risk of overdose, which leads to a sharp decrease in blood pressure. Treatment consists of hemodialysis and the introduction of plasma substitutes.

Kapoten can cause adverse reactions in the form of: anemia, thrombocytopenia, the appearance of an impurity of blood in the urine, tachycardia, acidosis, weight loss, aphthous stomatitis, abdominal pain. From the skin: rashes, itching.

What is the difference

Manufacturer Kapoten France, and Nifedipina – Ukraine.

Medicinal products differ in composition, including various active substances. For this reason, they can be found in more than one pharmacological group.

Each of them is prescribed individually and for certain diseases of the cardiovascular system that cause an increase in blood pressure.

When treating with Kapoten, patients with various disorders of the kidneys and liver belong to the risk group. Patients with various forms of heart failure remain vulnerable to nifedipine therapy.

It is important to avoid self-medication with any drug. The dosage can only be determined by the attending physician, starting from the indicators.

When and to whom is appointed

Usually, nifedipine is prescribed to people with a diagnosis of:

  1. Angina pectoris (chronic, stable).
  2. Angina pectoris (Prinzmetal, vasospastic).
  3. Coronary heart disease.
  4. Increased blood pressure (hypertension of various types).

Nifedipine is never prescribed for: severe forms of heart failure. acute myocardial infarction. rare cardiac arrhythmias. unstable angina pectoris. low blood pressure.

Do not treat pregnant and lactating. It is prescribed with caution to patients who have to drive vehicles or work with dangerous mechanisms. For patients with celiac disease, the drug is strictly prohibited, as it contains wheat starch.

Kapoten is prescribed to persons with a diagnosis of:

  • Myocardial infarction.
  • Asymptomatic left ventricular dysfunction, causing heart failure.
  • Macroproteinurial diabetic nephropathy (diabetes | type). hypertension.
  • Syndrome caused by decompensated myocardial dysfunction.

The drug is used together with diuretics, and sometimes with digitalis preparations.

For elderly patients with impaired renal function, the dosage is adjusted, starting with the smallest doses. For the treatment of children, the drug is used in severe forms of hypertension.

It is not used to treat patients with impaired renal function. Do not prescribe to pregnant, lactating and women planning a pregnancy.

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