Trental or Pentoxifylline, drug choice

Doctors, in the choice between these drugs, are guided by the severity of the course of the disease, its duration, concomitant diseases and the need for the onset of a quick effect, therefore, they mainly prescribe Trental in ampoules intravenously, because it meets these requirements. Patients are initially attracted by the low price of Pentoxifylline, and when a side effect occurs, due to the need for long-term treatment, they switch to Trental. Therefore, when choosing between these medicines, everyone will be guided by their preferences – action or price.

But it’s still better to consult a doctor, since undesirable effects from taking medications can be corrected, for example, with stomach pain, omeprazole could be used, before using Pentoxifylline to protect the stomach from irritating effects, with nausea – Cerucal to avoid decrease bowel tone. All undesirable effects can be eliminated by other means and it is the specialist who will help to figure this out.

Pathological changes in the central and peripheral vessels have become the most common and the question of their recovery worries many patients. The most prescribed agents for pathological processes in the vascular system are Trental and Pentoxifylline. These medicines belong to the same treatment line, contain the same main substance – pentoxifylline, but despite this they have similarities and differences. What do they consist of? Consider.


This is a vasodilator. It reduces blood pressure in the arteries, normalizes its composition in the direction of dilution, reduces the number of platelets, normalizes the oxygenated ability of red blood cells, and helps to normalize the state of all types of vessels.


Designed for recovery:

  1. Altered blood vessels in diabetes.
  2. Varicose veins.
  3. Conditions after ischemic stroke.
  4. Trophic ulcers.
  5. Large and small joints.
  6. Pathological changes in the eye vessels.
  7. Vascular changes in the ears.
  8. With leg cramps.

It is forbidden to use when:

  • Acute ischemia of the heart muscle.
  • Cerebral hemorrhage.
  • Tendency to nose and mucous bleeding.
  • Hypotension.
  • Cardiac arrhythmias.
  • Fetal bearing and breastfeeding.
  • Fragile vessels of the eye retina.
  • Individual intolerance to medicinal components.
  • Severe pathologies of the kidneys.
  • Gastritis and peptic ulcer in the acute stage.
  • Erosions and ulcers in the intestines.

Of the unwanted reactions, one can distinguish:

  • Pain and spin in the head.
  • Hypotension.
  • Cardiac arrhythmias and pains.
  • Swelling and rush of blood to the skin.
  • Anxious conditions.
  • Sleep impairment.
  • Pain in the epigastric region.
  • Violation of the stool, flatulence.
  • Thirsty.
  • Visual impairment.

This medication is made in tablet and ampoule forms. When combined with antibacterial drugs, blood thinners, nitrites, with substances affecting the number of platelets, it acts in the direction of strengthening. It is made in India.


The main therapeutic substance is pentoxifylline. Relieves spasm in large and small vessels, normalizes their permeability, helps to normalize blood consistency, prevents blood clots, helps normalize blood circulation and nourishes tissues with oxygen, improves muscle tone during breathing.


It is prescribed for:

  1. High blood pressure.
  2. Asthmatic attacks.
  3. Transient ischemic attacks.
  4. Rheumatism
  5. Trophic ulcers.
  6. Vascular changes in the fundus.
  7. Diseases of the vessels of the ears.
  8. Gallbladder inflammation.

It is forbidden to use when:

  • Low blood pressure.
  • Cardiac arrhythmias.
  • Violation of vascular permeability.
  • Ischemic conditions of the heart and brain.
  • Children and adolescents.
  • Fetal bearing and breastfeeding.

Undesirable effects:

  • A decrease in the number of leukocytes and platelets.
  • Visual impairment.
  • Insomnia, anxiety, headache.
  • Cardiac arrhythmias and pains.
  • Pain in the “pit of stomach”, lack of appetite, nausea.
  • Bleeding.
  • Redness of the skin, swelling.
  • Hepatitis, acute cholecystitis.

When used with antidiabetic, antihypertensive drugs and enhancing blood aggregation, increases their effect and can lead to hypoglycemic coma, bleeding. It is produced in Russia in the form of tablets and in solution. The course of treatment is long, for a month.

Similarity of drugs

The main therapeutic substance in Trental and Pentoxifylline is one – pentoxifylline. Available in the same forms. Both drugs have identical properties in the treatment of vascular changes, normalize the state of the blood, are used in the treatment of diabetic changes in blood vessels, both are preventive measures for strokes and heart attacks, prevent the formation of blood clots, are prescribed for the treatment of joints.

These drugs are excreted by the kidneys, therefore, with existing renal failure or other serious kidney diseases, dosage adjustment or complete drug withdrawal is necessary. Both one and the other have many contraindications and side effects.


Trental and Pentoxifylline differ in their manufacturers (India and Russia) and price. This difference is not accidental, since foreign drugs are more expensive than domestic and less toxic. There is a difference in the absorption of drugs, their excretion from the body and, accordingly, in the speed of action. Trental – is almost twice as fast absorbed and excreted, the therapeutic effect from its administration occurs faster than from Pentoxifylline. But the price of Trental is 10 times higher than that of the second medication. The undesirable effects of Pentoxifylline are faster and more pronounced than in Trental, since people taking it complain much faster about stomach pains, nausea, impaired and loss of appetite, then other symptoms appear, so long-term use of it becomes impossible. But the price is good.

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