Lisinopril or Diroton, which is more effective

When conducting an experiment in 2010, it was found that Lisinopril compared with Diroton is much more effective in lowering blood pressure. The experiment involved 50 people with hypertension.

When taking the first remedy, blood pressure returned to normal in 82% of patients. When taking Diroton – in 52%.

Cardiologists note that patients are well tolerated by both drugs. Side effects are rare.

Thus, despite the fact that according to the results of the studies, Lisinopril was recognized as a more effective drug, the doctor should prescribe treatment. Therapy of hypertension cannot be carried out without specialist supervision. Taking antihypertensive drugs can lead to a large number of side effects. The specialist selects the drug individually for each patient, based on age, disease and characteristics of the body.

Cardiovascular disease, stress, constant tension and unhealthy diets can lead to high blood pressure. In some people, this pathology may disappear on its own. However, in 80% of cases, the disease continues to progress. Without appropriate treatment, a person’s condition worsens, which can lead to complications. For the treatment of hypertension, antihypertensive drugs are prescribed. These are Diroton and Lisinopril. Many people are wondering which one is better. To answer this question, we need to consider them in more detail.


The active substance is lisinopril dihydrate. Available in tablet form. It has hypotensive, cardioprotective and vasodilating effects. The medicine prevents myocardial hypertrophy. Antihypertensive effect is observed 60 minutes after administration, and then increases over 6 hours. Persistent hypotensive effect appears after 2 weeks of regular use.


The intake of food does not affect the absorption of the substance. Communication with proteins is low. It is excreted by the kidneys unchanged. The elimination half-life is 12 hours.

Indications for use are:

  1. Hypertonic disease.
  2. Chronic heart failure.
  3. Type 2 diabetes.
  4. Acute myocardial infarction without increasing pressure.

An absolute contraindication is high sensitivity to the substances that make up the composition. It is also undesirable to use with:

  • Hyperkalemia
  • Anaphylactic shock in history.
  • Diseases of the liver and kidneys.
  • Renal artery stenosis.
  • Transplanted kidney.
  • Gout.
  • Old age.
  • History of Quincke’s edema.
  • Hypotension.
  • Children’s age.

Take 1 tablet in the morning, regardless of food intake. Around the same time, drinking plenty of water.


The active substance is lisinopril dihydrate. Available in tablet form. It has hypotensive and vasodilating effects. The maximum effect is observed after 6 hours. Further, it persists, but may vary depending on the dosage.


When absorbed from the digestive tract, the substance does not bind to proteins. Bioavailability of 25-30%, regardless of food intake. The elimination half-life is 12 hours. It is excreted by the kidneys unchanged. It does not have a withdrawal syndrome with a sudden cessation of taking the drug.

Indications are:

  1. Chronic heart failure (as part of combination therapy).
  2. Prevention of left ventricular dysfunction and heart failure.
  3. Diabetic nephropathy.
  4. Hypertonic disease.

Contraindications are:

  • History of angioedema.
  • Hereditary Quincke’s edema.
  • Children under 18 years old.
  • Pregnant and lactating women.
  • High sensitivity to the components of the drug.

Relative contraindications are:

  • Stenosis of the mouth of the aorta.
  • Kidney transplantation.
  • Renal failure.
  • Hypotension.
  • Cerebrovascular accident.
  • Diabetes.
  • Elderly patients.

It is necessary to take 1 tablet per day, regardless of the meal. Around the same time.

Similarities and differences

The specific drug and dosage are prescribed by the attending physician, based on the disease and condition of the patient. Both drugs are quite effective in the treatment of hypertension, but their joint use is strictly prohibited. An increase in the concentration of the active substance in the blood can lead to an overdose and the appearance of side effects.

Both medicines belong to the same pharmacological group, have the same active substance, as well as a mechanism of action. Despite the fact that the tablets are available without enteric coating, they can be taken regardless of food intake. Both medicines must be drunk at the same time 1 time per day.

Both medicines are made only in pill form. Not available in other dosage forms. The duration of the therapeutic effect of drugs is almost the same and a persistent hypotensive effect is observed after 2-4 weeks.

Neither drug should be taken by children, pregnant or lactating women. This can lead to severe side effects.

The main difference is that Diroton should not be taken by patients who have a history of Quincke edema. Lisinopril should not be taken in patients who are not lactose intolerant. The bioavailability of Diroton is 25% and the effect is observed after 7 hours, and the bioavailability of Lisinopril is 30%. The effect is observed after 6 hours.

Despite the fact that both contain the same amount of substance, the dosage is different for them. Diroton should be taken per day at 10 mg, while Lisinopril can be taken in a dosage half as much.

If used improperly, both medicines have a lot of side effects that start from ordinary dizziness and end with Quincke’s edema or anaphylactic shock.

The difference is the price. Lisinopril can be bought in the region of 100 rubles. The price of Diroton is 2-3 times higher.

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