Omeprazole or Pancreatin, which is more effective


  1. Helps people with peptic ulcer of the stomach, duodenum in acute form, as well as during remission, as it lowers the secretion of gastric juice, lowers acidity.
  2. By lowering the concentration of hydrochloric acid, it has an anti-inflammatory effect in reflux disease.
  3. Assign it to patients with acute and chronic pancreatitis, as it is able to anesthetize and eliminate foci of inflammation, relieve swelling of the tissues.
  4. Effective in the treatment of helicobacter. The drug creates an unfavorable environment for the reproduction and vital activity of these microorganisms.


  • It is recommended for eliminating pathologies of the pancreas and gastrointestinal diseases.
  • It is prescribed as a concomitant drug in the postoperative period, during the rehabilitation of the pancreas.
  • It is indicated after radiation therapy, before ultrasound.
  • Used in the complex treatment of pancreatitis.
  • Effective for overeating, indigestion (poor digestion of food), with a stool of liquid consistency.

The combined use of omeprazole with pancreatin is justified only in severe inflammatory processes of the gastrointestinal tract. Omeprazole will eliminate the causes of inflammation, Pancreatin, being an enzyme, will facilitate the work of the digestive tract. With an exacerbation of ulcerative conditions, it will help eliminate gas and bloating.

In other cases, the simultaneous use of drugs is not justified. Their intake should be timed to different meals.

Digestion disorders are a consequence of chronic inflammatory and dystrophic diseases of the stomach, intestines, pancreas, liver, gall bladder. Sometimes this occurs as a result of resection or irradiation of these organs. To restore and stabilize the condition, complex therapy is prescribed. A key role is given to Omeprazole and Pancreatinum. Patients are interested in which of the drugs is more effective, or are they both required in treatment? The answer can be obtained by carefully considering each individually.


The drug is among the pharmacological series with proton pump inhibitors. It is a tool intended for the treatment of acid-dependent gastrointestinal diseases. The action is carried out by reducing the concentration of hydrochloric acid. Therefore, omeprazole is classified as an antisecretory drug.


Available in the form of hard gelatin opaque capsules (20 mg). The case is white, the cover is red. Capsules contain omeprazole – the main active ingredient in the form of pellets (from white to beige).

Omeprazole has an antiulcer effect and inhibits the proton pump. Despite the source of the stimulus, the main substance reduces the level of basal and stimulated secretion. The therapeutic effect occurs within an hour and lasts up to 24 hours. In patients with a duodenal ulcer, taking one capsule allows you to maintain pH = 3 of the stomach for 17 hours. After the use of the drug is completed, secretory activity is restored for 5 days.

The drug normalizes metabolism, reduces inflammation, eliminates pain.

Before starting treatment, it is necessary to verify the absence of malignant tumors, for example, with a stomach ulcer, since the drug can mask the symptoms and prevent an accurate diagnosis.


Polyenzyme preparation is among the pharmacological group – enzymes and antifermenta. Available in the form of dragees. The surface is smooth, shiny. Brown colour.


Dragee consists of pancreatin and excipients, including glucose, lactose, sucrose. Packaged in blisters for 10 tablets.

The main therapeutic effect is the replacement of pancreatic enzyme deficiency. Auxiliary components: amylase (breaks down carbohydrates), protease (breaks down proteins), lipase (metabolizes fats). Due to this, they are completely absorbed in the small intestine. Trypsin improves the pancreas, eliminating pain.

Joint use with iron preparations, inhibits the absorption of the latter. Antacids lower the effectiveness of pancreatin.

General and distinctive characteristics

They can be noticed when considering the indications of drugs:

Omeprazole Pancreatin
Systemic heartburn Digestive Disorder Systematic
Gastric ulcers caused by Helicobakter pylori, NSAIDs, stress Pancreatitis (acute and chronic stage)
Zollinger-Ellinson syndrome, accompanied by the formation of tumors of the upper gastrointestinal tract Cholecystitis
Reflux esophagitis Cystic fibrosis
Gastritis Surgical intervention
Acute pancreatitis (to exclude the secretory function of the pancreas)

Both drugs help improve digestion, although they each work in their own direction.

They have a number of contraindications:

Omeprazole Pancreatin
Renal liver failure Intestinal thrombosis (obstruction)
Soft tissue swelling Patients under 2 years of age
Childhood Pregnant and lactating women
Pregnant and lactating women Individual intolerance
Individual intolerance

Most contraindications are similar. The advantages of pancreatin – use in the treatment of children.

Both drugs cause side effects:

Omeprazole Pancreatin
Disorders from the central nervous system in the form of irritability, apathy, depression Increases uric acid concentration
Functional disorders of the liver With cystic fibrosis, it can provoke obstruction in the small intestine.
 Diarrhea, constipation Itching of the skin
Flatulence, bloating Swelling, itching, discomfort within the anus
Nausea, vomiting
Lowers white blood cell count, platelet count
Immune system dysfunction
Functional impairment of the kidneys (rarely).

Omeprazole causes more serious side effects.

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