Isoprinosine or Groprinosin, drug choice

About two of these drugs, available in tablet form of 500 mg, we can say that children from three years of age and any age category of patients can take them. There is a slight inconvenience to count tablets by weight of the children. And here Groprinosin still has an advantage. Unlike Isoprinosine, it is also available in the form of syrup in a dosage of 50 mg / ml in a 150 ml bottle. Taking medication in this form is especially convenient for children, including older people with weak swallowing functions. This advantage of Groprinossin really gives the buyer a rational choice.

Like all antiviral drugs, treatment is best started on the first day of the disease. The effect will be significantly higher than with the inclusion of immunostimulating agents in the middle of treatment. Symptoms of the disease will not be so pronounced, and proceed in a milder form.

After suffering serious illnesses, or with weakened immunity, the question often arises of how to raise immunity and protect the body from repeated relapses of diseases and infections. With the modern rhythm of life, immunity carries a huge load. Often the body simply can not cope with elementary colds and viral infections. The disease does not recede for a long time. In such cases, he needs help from outside, and doctors can prescribe an immunostimulating agent.

Inosine pranobex

Doctors prescribe drugs under the international nonproprietary name. And so, the buyer is faced with the task of acquiring a reliable means of trade name. First, let’s try to figure out which medicinal substance is part of these tablets.

Inosine Pranobex is part of the pharmacological group of immunostimulating substances. The substance contains a two-component complex, which contains a purine derivative – inosine. It has a non-specific effect on viral cells. At the time of reduced immunity, restores the function of lymphocytes.

It stimulates the activity of T-lymphocytes and natural large granular lymphocytes, which have a cytotoxic effect against tumor cells and viruses. Increases the natural production of immunoglobulin and protective blood cells. Reduces anti-inflammatory cytokines. It destroys viruses due to its ability to slow the progress of the enzymatic reaction of viral RNA and inhibit the enzymes involved in the replication (copying) of viruses.

Inosine Pranobex is produced by several manufacturers in the pharmaceutical market. In this case, we will consider two trade names: Isoprinosine, manufactured by the Portuguese manufacturer of Luzomedicament-Technical Pharmaceutical Society with the holder of RU Teva Pharmaceutical Enterprises Ltd., and Groprinosin, manufactured by the Polish manufacturer LLC Gideon Richter Poland, with Hungarian holder of RU Gideon Richter OJSC.

The drug is perfectly absorbed in the digestive tract and reaches the required level of a substance in the blood plasma after 1-2 hours. It is rapidly metabolized and excreted by the kidneys after 24-48 hours. This two-component preparation, consisting of a molecule of inosine and salt, is highly effective due to its structure. A complex salt of acetamidobenzoic acid increases the availability of the complex for lymphocytes, at the moment when inosine blocks the reproduction of the virus by damaging the RNA of the virus.


The medicine is indicated:

  • With ordinary herpes of four types and genital, including laberal.
  • Shingles.
  • Chickenpox and other diseases caused by viruses of this group.
  • Measles proceeding with complications.
  • Cytomegalovirus, human papillomavirus infections and candidiasis.

The drug is calculated according to the body weight of a person. In case of acute infections, drug treatment is carried out for 2 weeks. Like all synthesized drugs, Isoprinosine can cause unforeseen reactions and has contraindications. These reactions include a feeling of nausea, sometimes vomiting, weakening of the intestines, skin itching, dizziness, general weakness.

The features can be considered a feeling of pain in the joints and exacerbation of diseases associated with the deposition of urate crystals (gout), since Inosine Pranobex participates in metabolic processes in the body with the formation of uric acid. Because sufferers of gout, this drug should be used under the supervision of a doctor with regular tests. Immunosuppressive drugs and diuretics can reduce the effect of Isoprinosine. Refuse to take “Isoprinosine” should be in the presence of these diseases:

  1. Gout.
  2. Urolithiasis and chronic kidney disease.
  3. Tendency to allergic reactions.
  4. Arrhythmias.
  5. Children under three years of age are contraindicated, including pregnant and lactating women.

Polish inosine fully complies with the pharmacodynamics, indications and contraindications of Isoprinosine. It includes the same molecule of the active substance. In the list of indications for use, you can add that it is prescribed even with subacute sclerosing panencephalitis.


In this case, one can believe that the clinical trials were successful in this disease and it was included in the list of indications in the instructions for use. Based on the chemical point of view, there is no difference between these drugs.

Are there any differences between the drugs?

The tablet form of release differs only in the auxiliary substances that make up the tablets. The amount of active substance in tablets of both manufacturers is 500 mg each . In addition to the same substance with the molecule, the Isoprinosin tablet also includes: mannitol, wheat starch, povidone and magnesium stearate.

The composition of Groprinosin includes: potato starch, povidone and magnesium stearate. The composition of the tablet shows that there are almost no differences in excipients. In any case, all of these substances are approved for use in the food industry.

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