Captopril or Anaprilin, drug choice

Both drugs are emergency remedies for severe hypertensive crises. They are widespread and over-the-counter. The pricing policy of both funds is below average, which makes them as affordable as possible for consumers. Both Captopril and Anaprilin are available as tablets for oral use.

There are two main differences between Captopril and Anaprilin:

  1. The method of exposure of these funds to the body.
  2. The specifics of their application.

Despite the main property of both drugs (providing a hypotensive effect), the principle of their action is completely different. Captopril is an inhibitory drug that affects the amount of angiotensin (hormone), which is responsible for the degree of expansion of blood vessels.

Lowering the level of this hormone, the vessels become more elastic and expand, blood pressure drops. Anaprilin is a non-selective beta-blocker that reduces the frequency of heart impulses, increasing the tone of arterioles and increasing peripheral vascular resistance. When using this substance, a pronounced drop in blood pressure is observed.

Hypertension is considered to be a younger disease, because every day doctors record more and more cases of the development of hypertensive crises in the young population. Of course, high blood pressure requires complex treatment to restore the functions of the cardiovascular system. But first, a person needs to provide emergency assistance.

To quickly lower blood pressure, the most commonly used drugs are Captopril and Anaprilin. Which remedy is better and under what circumstances?


White or off-white tablets that contain. Active ingredient ( captopril ), 25 mg or 50 mg in one tablet.


Captopril is an inhibitory substance with a hypotensive effect. It helps to reduce the hormone that provokes vasoconstriction (a significant narrowing of the blood vessels), and also promotes the release of aldosterone. Under the influence of the drug, the peripheral resistance of the vessels decreases, which reduces their load. Already 15 minutes after administration, there is a significant change in blood circulation pressure in the small blood circle, as well as in the right atrium.

Captopril is prescribed for:

  • Arterial hypertension.
  • Congestive Heart Failure.
  • Cardiomyalgia.
  • Violation of the functions of the left ventricle.
  • Ischemic diseases (stable condition of the patient after a heart attack).
  • Microalbuminuria.
  • Diabetes mellitus insulin-dependent form.
  • Diseases of the kidneys that cause jumps in blood pressure.
  • Rhinovascular disorders.

The drug can be used as a means of complex therapy for the treatment of diabetic nephropathy.

The optimal daily dose of the drug is established based on the general condition of the person and the type of disease. The maximum dose for a single dose is 50 mg. The maximum daily dose for an adult is 150 mg. Basically, in the treatment of hypertensive crises, 12.5 mg (half a tablet) is prescribed three times a day. The drug is taken on an empty stomach or half an hour before a meal. The tablet is placed under the tongue and absorbed.

Among the contraindications for the use of Captopril, there are:

  1. Quincke’s edema.
  2. Severe impairment of kidney function.
  3. An increased amount of potassium in the body.
  4. Renal artery stenosis (unilateral or bilateral).
  5. Progressive azotemia.
  6. Obstructive changes in internal organs that impede the outflow of blood in the left ventricle.
  7. Pregnancy and lactation.
  8. Intolerance to inhibitory drugs.

After using the drug, dermatological rashes may occur, the amount of protein in the urine, anemia (low white blood cell count), agranulocytosis increase. Some people notice changes in taste.


White or almost white small tablets, cylindrical in shape. The active substance is propranolol hydrochloride 10 mg or 40 mg in one tablet.


The drug is included in the group of non-selective beta-blockers with membrane-stabilizing properties. The active substance acts on the principle of blocking the pulsation of myocardial receptors, which can significantly reduce the number of heart contractions. With this effect, the heart muscles do not have an increased need for oxygen, which allows you to normalize blood pressure and increase the tone of the bronchial muscles. Such a grown action leads to accelerated uterine contraction in women, and the secretory function of the gastrointestinal tract improves.

Anaprilin is indicated for:

  • Coronary artery disease.
  • Hypertensive crises.
  • Chronic hypertensive syndrome.
  • Heart rhythm disturbances.
  • Thyrotoxinosis.
  • Tachycardia.
  • Unstable or intense angina pectoris.
  • Essential tremor.
  • Migraine attacks.

The drug is often used to treat and prevent anxiety disorder and panic attacks.

Anaprilin tablets are taken before meals, washed down with plenty of water. The dosage is prescribed individually, based on the complexity of the disease. Start with 10 mg per day, once. If the product is well tolerated by the body and does not cause adverse reactions, then the dose is increased to 100 mg per day, with a multiplicity of 4-6 times. If the drug has a mild effect, then the daily dose can reach 300 mg.

Anaprilin is contraindicated:

  • With sinus or atrioventricular bradycardia.
  • Sinoarterial blockade.
  • People suffering from angina pectoris.
  • In the case of arterial hypotension of uncertain origin.
  • With metabolic acidosis.
  • With all forms of diabetes.
  • People with vasomotor rhinitis.
  • With Raynaud’s disease.

Among the side effects that have arisen as a result of taking the drug, one can observe: headache, nausea, gastrointestinal tract disorders, dizziness, pain and pain in the stomach, disturbances in the sleep cycle (insomnia or increased drowsiness), cough, shortness of breath, exacerbation of rashes of psoriatic diseases (with their availability).

Which one is better and under what circumstances?

It is worth noting immediately that both drugs are not intended for long-term use, but are emergency help to quickly eliminate the symptoms of hypertension. The effect of their intake is short-term and non-cumulative (the facilitated condition is not fixed).

To understand when and which remedy is best to take, it will be enough to study all the indications for use, as well as contraindications and possible side effects.

Anaprilin acts faster and reduces pressure to a greater extent, but this drug has many contraindications, including diabetes, rhinitis, bradycardia, acidosis and hypotension. Captopril, although weaker, does not have such strict contraindications, it is well tolerated. Therefore, if a person suffers from disorders of the cardiovascular system, pancreas, kidneys or adrenal glands, taking Captopril tablet will have a much lower risk of side effects.

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