Concor and enalapril, drug choice

Both medicines are prescription drugs, so they should not be treated without consulting a doctor.

Concor and enalapril are used to normalize high blood pressure. These drugs have not only similarities, but also differences that need to be known before starting treatment with them.


Concor contains bisoprolol as an active ingredient .


The medication is available in tablets in 2 dosages:

  1. 5 mg tablets are heart-shaped, biconvex. They are light yellow in color, on each side they are at risk.
  2. 10 mg tablets are the same, only their color is light orange.

The composition of the medicine includes the following additional components:

  • E383.
  • E551.
  • MCC.
  • E1202.
  • Maize starch.
  • E576.
  • Hypromellose.
  • E1521.
  • Titanium dioxide.
  • E900.
  • Iron oxide is yellow.

The composition of 10 mg tablets additionally includes red iron hydroxide.

Bisoprolol belongs to selective β1-blockers. The active substance makes the pulse less frequent, reduces the oxygen demand of the heart muscle, the general peripheral vascular resistance, and blood pressure. In most patients, the maximum antihypertensive effect is observed 14 days after the start of therapy.

Once in the body, the drug is almost completely absorbed from the digestive tract. The bioavailability of bisoprolol reaches 90%. The maximum drug content in the bloodstream is noted after 3 hours. Bisoprolol is metabolized in the liver. Up to 30% of the accepted dosage combines with plasma proteins. The medicine is removed through the kidneys and through the intestines. The half-life of the drug is 10-12 hours.

Concor is prescribed for the treatment of the following pathologies:

  • Chronic heart failure.
  • Arterial hypertension.
  • Angina pectoris.

Enalapril belongs to the group of ACE blockers, it prevents the conversion of angiotensin I into angiotensin II, which stimulates the production of aldosterone in the adrenal cortex and constricts blood vessels. Against the background of therapy, afterload and preload decreases, the minute volume of the heart increases, the patient tolerates physical activity more easily. The drug slows the progression of heart failure, prevents the expansion of the left ventricle, reduces the incidence of myocardial infarction.


Enalapril is available in tablets and injections by a number of Russian and foreign companies, so the composition of its auxiliary components may vary significantly.

Up to 60% of the drunk dose is absorbed in the digestive tract. Passing through the hepatic barrier, enalapril is metabolized. Communication with blood plasma proteins can vary from 50 to 60%.

The half-life is 11 hours, in people with impaired renal function, it lengthens. After oral administration, up to 60% of the dose is excreted by the kidneys, up to 33% through the intestines. After the drug is injected into the vein, it is completely excreted by the kidneys.

Enalapril is used to treat:

  • Arterial hypertension.
  • Chronic heart failure.

The drug is also prescribed for the prevention of coronary ischemia in patients with impaired left ventricular function, to reduce the risk of myocardial infarction, as well as to prevent the appearance of signs of heart failure in people with latent left ventricular dysfunction.

What is common between means

Concor and enalapril have the following similarities:

  • Both drugs are not for children and nursing patients.
  • Both medicines can provoke a strong decrease in pressure, alopecia, allergies, impotence, dizziness, headaches, weakness, sleep disturbance, depression, hepatitis, nausea, vomiting, loose stools, difficulty in bowel movement, and increased activity of liver enzymes.
Comparison and how do they differ

Antihypertensive drugs have the following differences:

  1. Enalapril is not allowed during gestation. Bisoprolol is allowed for pregnant patients according to strict indications.
  2. Concor can cause a slowing of the heartbeat, progression of heart failure, cooling and numbness of the extremities, muscle spasms, muscle weakness, exacerbation of psoriasis, bronchospasm, hearing problems, lacrimation, inflammation of the conjunctiva, nervousness, sensory disturbance, tinnitus, dry mouth, pain in the abdominal cavity, pathologies of the kidneys and liver, glossitis, pancreatitis, the appearance of protein in the urine, and a decrease in white blood cells. Enalapril treatment may cause fainting, chest pains, hot flashes, cramps, dry cough, nightmares, hallucinations.
So what to choose?

An antihypertensive medication should be selected by a cardiologist taking into account the diagnosis, available contraindications, patient tolerance. It is impossible to say which drug is better, since each of them has many restrictions on the use and adverse reactions.

Concor should not be drunk in the presence of the following pathologies:

  • Intolerance to the composition of the tablets.
  • Bradycardia
  • Severe form of arterial hypotension, when the upper pressure is less than 100 mm RT. Art..
  • Severe bronchial asthma.
  • Severe circulatory disorders in the peripheral vessels, Raynaud’s disease.
  • Cardiogenic shock.
  • The acute stage of heart failure, decompensated heart failure, in which treatment with drugs with an inotropic effect is indicated.
  • The shift in blood pH to the acidic side.
  • Weakness of the sinus node.
  • Sinoatrial block, atrioventricular block 2 and 3 degrees.
  • Pheochromocytoma.

With caution, Concor therapy should be carried out if the patient receives desensitizing treatment, adheres to a strict diet, or he has the following pathologies:

  1. Unstable angina pectoris.
  2. Hyperthyroidism.
  3. Insulin-dependent diabetes.
  4. AV block 1 degree.
  5. Severe pathologies of the liver and kidneys, in which the creatine clearance is less than 20 ml per minute.
  6. Psoriasis.
  7. Heart defects.
  8. Chronic heart failure with myocardial infarction in the last 3 months.
  9. Strong cold.

Enalapril is not possible if the patient is diagnosed with the following pathologies:

  • A history of Quincke’s edema.
  • Renal artery stenosis.
  • Porphyria.
  • Intolerance to the composition of the drug.
  • Increased potassium in the bloodstream.

With caution, enalapril should be prescribed in combination with aliskiren to diabetics and patients with kidney pathologies in which the glomerular filtration rate is less than 60 ml per minute.

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