Klacid and Amoxiclav, the choice of drug

Despite the different affiliation to pharmacological groups, both are effective in diseases of the respiratory tract and ENT organs. They are characterized by a wide spectrum of antibacterial action. One to two weeks are accepted. However, the list of contraindications and the principle of exposure to substances varies. Therefore, the adoption of a drug will depend on many reasons. Before discharging the drug, a specialist is required to make an analysis of the sensitivity of microorganisms to them.

Many diseases associated with bacterial infections are treated with antibiotics. Effective among them are drugs from the group of macrolides and penicillins – clacid and amoxiclav. But how do they differ? Which one is safer?

General information

Antibiotics were used in the first half of the 20th century. During this time, scientists and the pharmaceutical industry put them on stream, which led to a huge number of their species and groups. Antibiotics – a substance of natural origin, on the basis of which synthetic derivatives are produced.

Klacid and Amoxiclav belong to different pharmacological groups, but are used for some similar diseases. Sometimes one antibiotic is replaced by another if recovery does not occur. Which one is safer and more effective? And when to use what?


Klacid is an antibiotic ( clarithromycin ) of the macrolide group. A feature of his work is that he binds to the 50S ribosomal subunit of sensitive bacteria and inhibits protein synthesis. Eliminates aerobic and anaerobic gram-negative and gram-positive organisms.


Klacid is available in several forms:

  1. Yellow pills. There are two types: 250 mg (10 pieces per pack) or 500 mg (14 pieces per pack).
  2. The powder is white. From it make a suspension. To reduce the bitterness of taste, added fruit aroma. Dosage: 125mg / 5ml and 250mg / 5ml. The packages have a syringe or spoon for easy dosage.
  3. Lyophilisate. From it make a solution for intravenous injection. It is white in 500 mg per vial.

Taking the medicine does not depend on food intake.

It is prescribed for the following ailments:

  • Respiratory tract (tracheitis, bronchitis, pneumonia).
  • Conjunctivitis.
  • Whooping cough.
  • Gastric ulcer processes provoked by Helicobacter pylori.
  • For problems with ENT organs.
  • Chlamydial infections.

Despite its positive qualities, Klacid will not help with the presence of some gram-negative bacteria (for example, Pseudomonas aeruginosa). Like many other antibiotics, side effects can not be avoided. By and large, they relate to the gastrointestinal tract (nausea, diarrhea), possibly a breakdown of the nervous system, headache.

Contraindications for admission:

  • Hypersensitivity to macrolide substances.
  • Kidney and liver dysfunction.
  • Combination with some other drugs.
  • Pregnancy.
  • Lactation period.
  • Childhood.

Klacid is excreted by the kidneys or liver, if taken parenterally, so a patient with problems with these organs will need additional consultation.


Amoxiclav is an antibiotic of the penicillin group. It has a wide effect (amoxicillin) with a beta-lactamase inhibitor (clavulanic acid). Clavulanic acid blocks the pressing of bacterial enzymes. The antibiotic destroys anaerobic gram-negative and gram-positive microorganisms.


Produced in the following forms:

  1. White pills. Usually prescribed 250/125 mg or 500/125 mg (the first indicator is the content of amoxicillin, the second – clavulanic acid). In one bottle – 15 pieces.
  2. Powder. A suspension is prepared from it. Dosage – 125 mg of amoxicillin and 31.25 mg of clavulonic acid.
  3. Lyophilisate. From it make a solution for injection. Dosage – 500/100 mg and 1000/200 mg.

You can take the medicine regardless of the meal.

Helps with the following diseases:

  • Respiratory tract and ENT organs.
  • Biliary and urinary tract.
  • With genital infections.
  • Gastrointestinal Disorder Provoked by Helicobacter pylori.
  • In gynecology.
  • Skin and soft tissue.

Amoxiclav effectively eliminates bacteria, but it fails to destroy some: ureaplasma, pseudomonas and chlamydia. From side effects: problems with the gastrointestinal tract, headache and skin rashes.

Contraindications for admission:

  • Intolerance to the substances of the penicillin group.
  • Hepatitis.
  • Liver and kidney problems.
  • Mononucleosis.
  • Colitis.
  • Pregnancy.
  • Lactation period.
The difference between Klacid and Amoxiclav

Klacid is an “original” antibiotic, i.e. it was created “from scratch”, from which other analogues arose. Amoxiclav is an analogue of Augmentin, which also contains amoxicillin and clavulanic acid. However, this does not diminish its merits. Due to the fact that Klacid is “original”, its cost is much higher. Therefore, sometimes the deciding factor may be the price when choosing a drug. But still take into account medical indications.

According to therapeutic indicators, Klacid has a more powerful effect. Amoxiclav is milder, but its toxicity is lower. Klacid fights against difficult, persistent infectious diseases, and the second is useful in the uncomplicated course of the disease.

Amoxiclav is excreted quickly and completely from the body. Mostly through the kidneys. It does not penetrate into the cerebrospinal fluid, therefore it causes little disturbance in the central nervous system. Klacid is also easily excreted, mainly through the kidneys, if the substance enters the stomach, or through the liver, if the patient has used parenteral administration of the drug. But it has a more depressing effect on the nervous system.

Both antibiotics can become useless against some bacteria. Klacid will not suppress germs of intestinal infections. Amoxiclav does not eliminate tuberculosis bacteria and genital infections. Knowing about these shortcomings, the specialist will adjust the treatment.

Prescribing Klacid or Amoxiclav

Which antibiotic is suitable for treatment, the specialist decides. He collects his anamnesis and predicts which one will cope with a certain disease.

As a rule, if an infectious disease does not carry serious complications, they may suggest trying Amoxiclav. It is more conveniently tolerated and less inhibits the functionality of the body. Often it is recommended for diseases of the respiratory tract, which were caused by common pathogens. Klacid – with persistent infections.

Amoxiclav is suitable for children. Doctors are not afraid to prescribe it even for babies older than six months. Klacid is preferred to be offered closer to 12 years of age.

Also, Amoxiclav can be prescribed to pregnant women who need it for health reasons. Klacid is not recommended.

Klacid may be ineffective when interacting with other medicines and even harm. Therefore, if the patient is forced to take other medications, he or the doctor should pay attention to this. Amoxiclav also should not be combined with other medicines, but their list is shorter.

Klacid is preferably prescribed to older people. It can be canceled if the patient is intolerant to substances of the penicillin group, and can be reassigned to Amoxiclav.

Which drug the patient will take depends on the course of the disease and analysis of the sensitivity of the antibiotic to microorganisms.

Antibiotics are a good medicine, but do not take it frivolously. They are prescribed only by a doctor and strictly follow the instructions for admission. If the patient has an opinion about the prescription incorrectness, then you should not change something yourself. You need to consult with another specialist.

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