Zinnat and Suprax are not interchangeable and only a doctor can choose the right antibiotic therapy depending on the age of the patient, the sensitivity of the pathogen to the antimicrobial agent, the patient’s contraindications, and tolerance to the medicine.
Zinnat and Supraks are cephalosporin antibiotics that have a wide spectrum of action. Both medicines are taken orally.
They can be drunk with infections of the respiratory system, digestive tract, and genitourinary system.
Zinnat and Supraks have the following differences:
- Zinnat is contraindicated in children under 3 months. Suprax is allowed from 6 months.
- Zinnat is contraindicated in phenolketonuria. With caution, Suprax should be drunk in old age, in patients with chronic renal failure, with antibiotic-associated diarrhea.
- Suprax can cause dry mouth, bloating, refusal to eat, stomatitis, glossitis, interstitial nephritis. Due to taking Zinnat, there may be a positive Coombs test.
Zinnat
Zinnat is available in tablets and granules for the manufacture of a suspension. As a therapeutic component, the medicine contains cefuroxime.
Tablets come in 125 mg and 250 mg. They are coated with a white or almost white film coating. They are oval and biconvex, on tablets of 125 mg there is an inscription “GX ES5”, on the drug in a dosage of 250 mg – “GX ES7”.
The composition of the tablets includes the following excipients:
- MCC.
- Aerosil.
- E468.
- E487.
- Hydrogenated Vegetable Oil.
The shell of the tablets is formed by the following components:
- Macrogol.
- E216.
- E218.
- E171.
- E4644
- Sodium benzoate.
The granules are white or almost white; they have an irregular shape. They are of different sizes, but with a maximum of 3 mm. The color of the finished suspension can vary from white to pale yellow, it has a characteristic smell of fruit.
Granules contain the following additional ingredients:
- Fragrance of tutti-frutti.
- Octadecanoic acid.
- E473.
- E950.
- E951.
- Povidone K30.
- Water.
- E415.
Cefuroxime belongs to the II generation cephalosporins. It inhibits the formation of the cell wall of microorganisms, as a result they die.
The antibiotic is effective against the following pathogenic agents:
- Haemophilus influenzae.
- Escherichia coli.
- Salmonella.
- Shigella.
- Gonococci.
- Proteins.
- Enterobacteria.
- Staphylococci, except for methicillin-resistant species.
- Streptococcus
The following microorganisms are resistant to it:
- Pseudomonads.
- Enterococci.
- Listeria.
The antibiotic is rapidly absorbed from the digestive tract. Up to 50% of the dose taken is associated with proteins. The drug is rapidly distributed in fluids and tissues, in cerebrospinal fluid therapeutic concentration is observed only with inflammation of the meninges. The antibiotic crosses the placenta and is secreted through the mammary glands. The antimicrobial agent is excreted through the kidneys unchanged.
Suprax
Suprax is available in capsules and granules, from which a suspension is prepared. In addition, Supraks Solutab, which is produced in soluble tablets, is on sale.
The therapeutic effect of the medication is explained by cefixime.
The capsules have a purple cap and a white body, they have the inscription “H808” on them . Inside them contains a yellowish-white mixture, which consists of small granules and powder.
They contain the following additional components:
- E551.
- E576.
- Carmellose calcium.
The gelatin capsule is formed by the following substances:
- E171.
- E122.
- E132.
- E441.
Food ink has the following composition:
- E171.
- Macrogol.
- E904.
- E1510.
- E524.
- Povidone.
- Butyl and isopropyl alcohol.
The granules are small, the color can vary from white to cream. The finished suspension smells like strawberries, it is the same color as the granules.
The composition of the granules includes the following additional ingredients:
- Fragrance strawberry.
- E415.
- E473.
- E211.
Dispersible oblong tablet with strawberry flavor. They are light orange, on both sides they have a risk.
They contain the following additional substances:
- MCC.
- E551.
- E576.
- Fragrance strawberry.
- E110.
- Povidone.
- E463.
- E964.
Cefixime is a semi – synthetic antibiotic of the third generation of the cephalosporin series, which exhibits a bactericidal effect. It inhibits the formation of the cell wall of microbes, as a result they die.
The antimicrobial agent is active against the following bacteria:
- Streptococcus
- Pfeiffer’s wand.
- Salmonella.
- Shigella.
- Proteus.
- Klebsiella.
- Citrobacters.
- Providence.
- Serrations.
- Pasteurella.
Cefixime is not active against the following bacteria:
- Pseudomonads.
- Enterococci.
- Clostridia.
- Bacteroid frailis.
- Listeria.
Many staphylococci are resistant to cefixime, including methicillin-resistant strains.
The bioavailability of the antibiotic varies from 40% to 50%, the maximum concentration of 0.8 h is achieved faster if you drink the medicine at the same time with food. Up to 65% of the accepted dosage binds to plasma proteins. About half of the dosage taken is excreted through the kidneys unchanged during the first day, about 10% through the intestines. The elimination half-life varies from 3 to 4 hours. In patients with kidney pathologies, due to which creatine clearance of not more than 40 ml per minute, the elimination half-life is extended to 6.4 hours, when creatine clearance does not exceed more than 10 ml per minute – up to 11.5 hours.
