Tri-regol or Regulon, drug choice

It is impossible to say unequivocally that Tri-regol or Regulon is better; a gynecologist should choose oral contraceptives taking into account the individual characteristics of the female body.

Tri-regol and Regulon are oral contraceptives. Although medicines belong to the same clinical and pharmacological group, there are many differences between them that need to be clarified before taking hormonal contraceptives.


On sale is Tri-regol or Tri-regol 21 + 7.

Tri-regol 21 + 7 contains 4 types of tablets, 28 of them in a package:

  1. Tablets I are covered with a pink shell, they are round, biconvex. Their surface is glossy, at the cut they are white. As the main components contain 30 μg of ethinyl estradiol and 50 μg of levonorgestrel.
  2. Tablets II are biconvex, round in shape with a glossy surface. They are covered with a white shell, inside a white core. They contain 40 micrograms of ethinyl estradiol and 75 micrograms of levonorgestrel.
  3. Tablets III are round, biconvex, glossy, dark yellow in color, white in section. They contain 30 μg of ethinyl estradiol and 125 μg of levonorgestrel as the main ingredients.
  4. Tablets IV have a round, biconvex shape, they are covered with a reddish-brown shell, pale brown on the break. This is a placebo pill they contain iron fumarate.


As additional components, tablets contain:

  • Aerosil.
  • E576.
  • Maize starch.
  • Milk sugar.
  • E553b.

The shell is formed by the following substances:

  • Sucrose.
  • E171.
  • Carmellose sodium.
  • E553b.
  • Calcium carbonate.
  • Copovidone.
  • Propylene glycol.
  • Aerosil.
  • Povidone.
  • Iron oxide red (tablets I) or yellow (tablets III and IV).

Packaging Tri-regol, unlike the drug Tri-regol 21 + 7, contains only 21 tablets, it does not contain a placebo.

Tri-regol is a combined three-phase contraceptive. It blocks the production of LH and FSH in the pituitary gland, increases the viscosity of cervical mucus, which interferes with the movement of sperm. Against the background of taking the drug, ovulation is suppressed.

Levonorgestrel quickly binds from the digestive tract, most of it binds to proteins. The elimination half-life can vary from 8 to 30 hours.

Ethinyl estradiol is rapidly and almost completely absorbed from the digestive tract, its maximum content in the blood is reached after 1-1.5 hours. In the liver and intestines, it is metabolized. The half-life is 26 ± 6.8 hours.


Regulon is available in tablets, which are coated with a white or almost white shell. They are round, biconvex. The inscription “P8” is on one side of the tablet, and “RG” on the other.


The contraceptive effect is due to desogestrel and ethinyl estradiol.

In addition to them, Regulon includes inactive components:

  • Vitamin E.
  • E576.
  • Aerosil.
  • Povidone.
  • Milk sugar.
  • Potato starch.
  • E570.
  • Macrogol.
  • Hypromellose.

Regulon refers to monophasic oral contraceptives. The mechanism of its action is associated with the suppression of the biosynthesis of gonadotropic hormones and ovulation. Against the background of contraceptive use, the viscosity of cervical mucus increases, as a result of which the movement of sperm cells along the endocercis slows down. In addition, the state of the endometrium changes, and a fertilized egg cannot be implanted.

A contraceptive has a positive effect on lipid metabolism, it increases the level of HDL in the blood. It normalizes the menstrual cycle, reduce blood loss during menstruation.

The medication has a positive effect on the condition of the skin, especially in the presence of acne.

Desogestrel is rapidly and almost completely absorbed from the digestive tract. Its bioavailability can vary from 62 to 81%. The maximum content is reached after 1.5 hours. In the liver and intestines, desogestrel is metabolized. It is excreted through the kidneys and intestines. The half-life is 30 hours.

Ethinyl estradiol is well absorbed from the digestive tract. The highest concentration is reached after 1 or 2 hours. Its bioavailability is 60%. Its connection with proteins is 100%. Passing through the liver, it undergoes metabolism. About 40% of the dosage taken is excreted in the urine, the rest with feces. The average half-life is one day.
What is common between drugs

Tri-regol and Regulon have the following similarities:

  1. Medicines are used to prevent the occurrence of an unwanted pregnancy.
  2. Contraceptives are manufactured by Gideon Richter, Hungary.
  3. Both drugs can not be pregnant and lactating, with individual intolerance to their composition, severe liver dysfunction, jaundice due to hormones, bleeding from the genital tract of unknown origin, uncompensated diabetes mellitus, otosclerosis and pruritus in a previous pregnancy, congenital increase in the level of bilirubin in the blood, stones in the gall bladder, pancreatitis, accompanied by an increased level of lipids in the blood, malignant tumors of the breast and genital organs, migraine, the risk of developing vascular thrombosis, smoking women over 35 years old .
  4. Oral contraceptives can cause allergies, nausea, vomiting, vaginal discharge, thrush, indigestion, acyclic bleeding from the genital tract, breast engorgement, gallstone disease, cholecystitis, chloasma, headache, discomfort when wearing contact lenses, weight gain, tolerance to glucose, depression, thrombosis and venous thromboembolism, hepatitis, increased pressure, rashes.
Comparison and differences

Tri-regol and Regulon have the following differences:

Tri-regol Regulon
Adverse reactions A contraceptive can cause a decrease in libido, swelling of the eyelids, conjunctival inflammation, vision problems, increased blood lipids and glucose, liver adenomas, jaundice, hair loss, weakness, staining of the stool black, irritation of the digestive tract, constipation. The drug can cause hemolytic-uremic syndrome, porphyria, hearing loss, arterial thromboembolism, exacerbation of lupus erythematosus, minor chorea, absence of menstruation, milk secretion from the chest unrelated to lactation, stomach pain, granulomatous and ulcerative colitis, migraine, an increase in the amount of fluid in the body.
Contraindications It is forbidden to drink tri-regol in the presence of cholecystitis, chronic colitis, severe dysfunctions of the cardiovascular system, cerebrovascular accident, leg surgery, prolonged immobilization, extensive injuries, sickle cell and chronic hemolytic anemia, idiopathic jaundice and herpes history of pregnancy.

A contraceptive should not be given to women over 40 years old.

With caution, the contraceptive should be drunk for diabetes, endocrine disorders, cardiovascular pathologies, kidney dysfunction, varicose veins, multiple sclerosis, epilepsy, bronchial asthma, tetany, porphyrin disease, rheumatic chorea.

Regulon should not be drunk with Gilbert’s disease.

With caution, it should be taken by women over 35 years old, with nicotine addiction, overweight, high blood lipids, high blood pressure, epilepsy, heart defects, atrial fibrillation, prolonged immobilization, leg surgery, varicose veins, superficial thrombophlebitis, severe depression, changes blood biochemistry, diabetes mellitus without vascular complications, systemic lupus erythematosus, ulcerative and granulomatous colitis, sickle cell anemia, in the postpartum period.

Storage rules The contraceptive should be stored at temperatures up to 25 degrees. The contraceptive does not lose its properties at a temperature of 15 to 30 degrees.
Shelf life Tri-regol is valid for 24 months. Regulon is valid for 36 months.

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