Fenistil and Suprastin, the choice of drug

The doctor should decide what is best for Fenistil or Suprastin, especially since these medications can cause a number of undesirable effects.

The gel and emulsion Fenistil can provoke the following side effects:

  1. Dry skin.
  2. Burning sensation.

Taking drops of Fenistil can cause undesirable effects such as:

  • Anxiety.
  • Fatigue, drowsiness.
  • Headaches, vertigo.
  • Dry mouth.
  • Nausea.
  • Dyspeptic disorders.

The following adverse reactions may occur during treatment with Suprastin:

  • Decrease in all uniform elements of blood.
  • Drowsiness, trembling of certain parts of the body, fatigue, headaches, cramps, euphoria, excessive agitation, encephalopathy.
  • Vision problems, glaucoma.
  • Hypotension, heart rate, heart rhythm disturbance.
  • Photosensitivity.
  • Myasthenia gravis
  • Gastralgia, dry mouth, nausea, vomiting, loose stools, constipation, weakening or increased appetite.
  • Urinary retention.

If adverse effects occur, specialist advice is required.

To treat allergies of various origins, antihistamines are used, which include Fenistil and Suprastin. Let’s see which drug is better when.


Fenistil is available in the form of an emulsion and gel for external use and drops for oral administration. The therapeutic effect of the medication is explained by dimetinden maleate.


The gel is a homogeneous, colorless, transparent or slightly opalescent mass that almost does not smell.

It consists of the following inactive components:

  • Trilon B.
  • Macrogol.
  • Carbomer.
  • Sodium hydroxide.
  • Benzalkonium chloride.
  • Water.

The emulsion is white, homogeneous, semi-liquid. It smells of benzyl alcohol. The composition of the emulsion includes the following additional ingredients:

  1. E1519.
  2. Benzalkonium chloride.
  3. Trilon B.
  4. Macrogol.
  5. Kokoil kaprilokaprat.
  6. Water.
  7. E524.
  8. Carbomer.
  9. Vaseline oil.
  10. E321.
  11. Cetostearomacrogol.

Drops are a clear, colorless liquid that is almost odorless.

They contain the following inactive substances:

  • E330.
  • Trilon B.
  • Macrogol.
  • Water.
  • E210.
  • E393.
  • E954.

The drug belongs to blockers of histamine H1 receptors. It has anti-allergic and antipruritic effect, reduces capillary permeability, which is increased due to the pathological process.

When taken orally, the antihistamine action begins in half an hour and reaches a maximum after 5 hours.

When applied to the skin, the medicine has a local anesthetic effect, reduces itching and irritation, which are caused by skin-allergic reactions. The gel has a cooling effect, it begins to act within a few minutes.

After oral administration, the drug is rapidly absorbed from the digestive tract, its highest concentration is reached after 2 hours. The bioavailability of the drops is 70%. Up to 90% of the drunk dosage binds to proteins. In the liver, the drug is metabolized. It is excreted through the intestines and kidneys, the half-life is 6 hours.

With external application, the drug penetrates the skin well, its bioavailability is 10%.


Suprastin is on sale in tablets and injections, which are done intramuscularly or intravenously. They contain chloropyramine hydrochloride as the main component .


The tablets are white, a grayish tint is allowed, they are without or practically odorless. On one side they have the name of the medication written, on the other there is a risk.

They contain the following inactive substances:

  • Milk sugar.
  • Potato starch.
  • E553b.
  • Gelatin.
  • KVM.
  • E570.

The solution is a clear, colorless liquid with a faint specific odor. As an additional component, it contains water for injection.

The medication has an antihistamine, m-anticholinergic, antiemetic effect. After oral administration, the drug begins to act within half an hour and is effective for at least 3-6 hours.

After oral administration, the drug is almost completely absorbed from the digestive tract. Passing through the liver, it undergoes metabolism. The drug is excreted mainly in urine.

What are the similar means

Fenistil and Suprastin have the following similarities:

  1. Both antihistamines are used for allergic diseases and pruritus of various origins.
  2. They are contraindicated in case of intolerance to their composition.
  3. In a suitable dosage form, antiallergic drugs are permitted for children older than 1 month.
  4. Drops Fenistil, injections and tablets Suprastin are contraindicated in bronchial asthma.
Comparison and how do they differ

Between Fenistil and Suprastin there are the following differences:

Fenistil Suprastin
Producing country Switzerland Hungary
Use during pregnancy and lactation Emulsion and gel are allowed during pregnancy and lactation. Drops are prohibited in the first 3 months of pregnancy. The medication is contraindicated in pregnant and lactating patients.
Terms of sale OTC medication. Injections can be bought with a prescription, tablets without.
Indications for use External dosage forms can be used for burns of various origins.
Contraindications All dosage forms are contraindicated in prostate adenoma, angle-closure glaucoma. With caution, drops should be drunk with epilepsy and cold. The medicine should be prescribed with caution to older people, patients with pathologies of the liver, kidneys, cardiovascular system, prostate adenoma, urinary retention, angle-closure glaucoma.
Effect on ability to drive a car Emulsion and gel do not adversely affect the ability to drive a car. When taking drops, you need to be careful on the roads. During therapy, you need to be careful when driving a car.

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