Spironolactone and Veroshpiron, drug choice

In addition to the fact that Spirolactone and Veroshpiron differ in the composition of auxiliary components, they still differ in storage conditions. Veroshpiron should be stored at temperatures up to 30 degrees. And, for example, Spirolactone manufactured by Synthesis OJSC does not lose its properties if tablets are stored at temperatures up to 25 degrees.

Medicines are completely interchangeable, the only thing that is important for an allergic person is to take into account: drugs differ in the composition of additional components.

Both diuretics are prescription therefore self-medication is prohibited by them.

Spironolactone and Veroshpiron belong to diuretics and are complete structural analogues. Despite this, there are differences between medications that need to be clarified before using diuretics.

Spironolactone

The drug is available in capsules and tablets by several domestic companies, so the composition of its auxiliary components may vary significantly.

Spironolactone is a magnesium and potassium-sparing diuretic. It increases the excretion of water, sodium and chlorine ions from the body, reduces the evacuation of urea and potassium, and reduces the acidity of urine. Against the background of taking the medication, the amount of urine increases, there is a decrease in blood pressure, but this effect is variable. The drug does not reduce normal blood pressure. The diuretic effect of the drug occurs on the 2nd to 5th day of therapy.

After oral administration, up to 90% of the drug is absorbed in the digestive tract. Passing through the liver, spironolactone is metabolized. It is excreted mainly with urine and in a small amount through the intestines. The half-life can vary from 13 to 24 hours.

Veroshpiron

Veroshpiron contains spironolactone as the main component . The medicine is available in tablets and capsules.

Tablets of 25 mg round, flat shape. They have a specific smell, chamfer, on one side the name of the drug is applied.

The composition of the tablets includes the following additional ingredients:

1. Aerosil.
2. E576.
3. E553b.
4. Milk sugar.
5. Corn starch.

For capsules of 50 mg, the lid is yellow and a white body; for the preparation of 100 mg, the lid is orange and the body is yellow. Inside they contain a white granular fine-grained powdery mass.

The composition of the capsules includes the following inactive components:

• E576.
• Milk sugar.
• E487.
• Corn starch.

50 mg capsules have the following composition:

1. The lid is formed by titanium white, gelatin and E 104.
2. The case consists of gelatin and titanium white.

100 mg capsules are formed by the following substances:

• The cover includes E110, gelatin and E171.
• The body is formed by gelatin, E110, E104, E171.

Key similarities

Both medicines are used to treat the following pathologies:

1. Essential hypertension.
2. Edema that occurs against the background of chronic heart failure.
3. Lowering the level of magnesium and potassium in the blood.
4. Primary and secondary hyperaldosteronism.

Against the background of treatment with diuretic agents, the following undesirable reactions may occur:

• Nausea, vomiting, upset stomach, digestive tract ulcer, gastrointestinal bleeding, gastritis, abdominal pain, stool retention, liver pathology.
• Lack of coordination, lethargy, vertigo, headache, lethargic sleep, impaired consciousness, drowsiness.
• Lowering the level of sodium, platelets and white blood cells, megaloblastosis.
• Disease, increased creatinine, urea, potassium, displacement of acid-base balance.
• Coarsening of the voice, enlargement of the mammary glands in men, erectile dysfunction, menstruation disorder, menstruation, menstruation, uterine bleeding during menopause, hairiness, mastalgia, breast carcinoma.
• Urtikaria, rashes, itching, drug fever.
• Leg cramps, muscle cramps.
• Acute renal failure.
• Pathological hair loss, hypertrichosis.

During treatment with diuretics, care must be taken when driving and in potentially hazardous activities.

If therapeutic dosages are exceeded, diuretics can cause poisoning, which is manifested by the following symptoms:

• Nausea.
• Vomiting
• Dizziness.
• Lowering blood pressure.
• Upset stool.
• Rash.
• Increased urea, calcium and potassium.
• Lower sodium levels.
• Dehydration.

If there are signs of poisoning, the victim is shown gastric lavage, the appointment of drugs that eliminate dehydration and normalize blood pressure. In severe intoxication, hemodialysis is prescribed.

You can not take these diuretics if there are the following pathologies:

1. Intolerance to the composition of the drug.
2. Increased levels of potassium in the blood.
3. Decrease in sodium in the body.
4. Impaired renal function, in which creatine clearance is less than 10 ml / min.
5. Lack of urination.
6. Addison’s disease.
7. Milk sugar intolerance, lack of lactase, malabsorption of dextrose and galactose.

Spirolactone-based drugs should not be taken by women in a position and supporting breastfeeding, children under 3 years of age.

With caution, they should be drunk by patients who have:

• High levels of calcium in the blood.
• Atrioventricular block, since due to the high level of potassium in the body, it can be amplified.
• Metabolic acidosis.
• Diabetes mellitus in combination with suspected and diagnosed chronic renal failure.
• Operation.
• Diabetic nephropathy.
• Treatment with medicines that cause gynecomastia.
• Elderly age.
• Menstruation.
• Local and general anesthesia.
• Impaired liver function, cirrhosis.