29.03.2024

Suprax and Augmentin, the choice of drug

What is better Augmentin or Suprax should be decided by the doctor. He selects the antibiotic therapy scheme depending on the sensitivity of the pathogen to the medication, the patient has concomitant diseases, his age, and tolerance to treatment.

Both medicines can be purchased at the pharmacy upon presentation of the prescription, therefore self-medication is prohibited by them.

Suprax and Augmentin are antibiotics. Despite this, the affiliation of both drugs to antimicrobials between medicines, there are many differences that are important to know before starting therapy.

Suprax

The therapeutic effect of Suprax is explained by cefixime, which belongs to III generation cephalosporins. An antimicrobial agent is active against microorganisms that produce β-lactamases. In contact with pathogenic agents, it blocks the formation of its cell wall, as a result of which the death of bacteria is observed.

Suprax

The following types of microbes are sensitive to an antimicrobial agent:

  • Escherichia coli.
  • Moraxella cataralis.
  • Streptococcus
  • Pfeiffer’s wand.
  • Proteus.
  • Gonococci.

In laboratory experiments, cefixime was found to be active against the following pathogenic agents:

  1. Shigella.
  2. Salmonella.
  3. Serrations.
  4. Citrobacters.
  5. Klebsiella.

The antibiotic does not affect staphylococci, bacteroids, pseudomonads, enterobacteria and clostridia.

The drug is available in capsules and granules from which a suspension is made for oral administration.

The composition of the capsules includes the following inactive components:

  • E171.
  • E576.
  • E551.
  • E132.
  • E122.
  • E441.
  • E1510.
  • E1201.
  • E904.
  • E524.
  • E1521.
  • Butanol
  • Isopropyl alcohol.
  • Carmellose calcium.

Granules contain as additional components:

  • E473.
  • E211.
  • E415.
  • Strawberry flavoring.
Augmentin

Augmentin contains amoxicillin and clavulanic acid as the main components . The antibiotic is available in tablets, in powders for the preparation of a suspension for oral administration and a solution for administration into a vein.

Augmentin

The tablets are white or almost white, oval in shape. On the drug with a dosage of 250 and 500 mg, the name of the medication is written. On 1000 mg tablets there is a risk and on both sides engraving “AS”. At the break, their color can vary from white to yellowish white.

As auxiliary components they contain:

  • E576.
  • MCC.
  • Aerosil.
  • Sodium KMK.

Their shell is formed by the following substances:

  1. E171.
  2. Hypromellose.
  3. Propylene glycol.
  4. Dimethicone (not available in 1000 mg tablets).

The powder from which the suspension is prepared is white or almost white, has a specific smell. The finished suspension, the same color, when standing, a white or almost white precipitate slowly precipitates.

The composition of the powder from which the suspension is made includes the following additional ingredients:

  • Aerosil.
  • Fragrances orange, raspberry, “Light stick”.
  • E464.
  • E363.
  • E951.
  • E415.

The powder for injection is white or almost white.

Amoxicillin is a semi-synthetic antibiotic that is destroyed by β-lactamases, so it does not affect the microorganisms that produce this enzyme.

Clavulanic acid blocks β-lactamases and protects amoxicillin from destruction, which significantly expands the spectrum of antimicrobial activity of the antibiotic.

Gram-positive and gram-negative microbes are sensitive to antibacterial agents:

  • Streptococcus
  • Staphylococci.
  • Fecal enterococcus.
  • Bacillus anthrax.
  • Helicobacter pylori.
  • Vibrio cholera.
  • Haemophilus influenzae.
  • Clostridia.
  • Nocardia asteroids.
  • Listeria.
  • Pertussis wand.
  • Moraxella.
  • Gonococci.
  • Pasteurella.
  • Peptococcus.
  • Peptostreptococcus.
  • Bacteroids.
  • Fusobacteria.
  • Aikenella Corrodens.
  • Porphyromonads.
  • Preotella.
  • The causative agents of Lyme disease, Weil.
  • Treponema pallidum.
  • Klebsiella.
  • Escherichia coli.
  • Salmonella.
  • Shigella.

The drug is rapidly absorbed from the digestive tract. The most complete absorption is observed if you take the medication at the beginning of the meal. The drug is rapidly distributed in the tissues. Up to 18% of amoxicillin and up to 25% of clavulanic acid bind to plasma proteins.

Both active substances are metabolized in the liver. Amoxicillin is excreted mainly in the urine, clavulanic acid is excreted through the intestines and kidneys.

Drug similarities

Antimicrobial agents have the following similarities:

  • Antibiotics are allowed to be taken during gestation. During treatment, they are advised to interrupt breastfeeding.
  • During therapy with both antimicrobial agents, care must be taken when driving and working with potentially dangerous mechanisms.
  • Both antibiotics are used for infections provoked by bacteria sensitive to them, including diseases of the respiratory system and urinary system, inflammation of the ear, skin, soft tissues, gonorrhea.
  • Medicines can not be used with intolerance to their composition, carbapenes and cephalosporins. With caution, antibiotics should be used in patients with kidney pathologies, a history of gastrointestinal diseases caused by antimicrobial treatment.
  • Both medicines can provoke allergies, nausea, vomiting, diarrhea, dysbiosis, cephalalgia, dizziness, glossitis, stomatitis, impaired liver and kidney function, bleeding, colitis, cramps, changes in blood composition, shortness of breath.
Comparison and differences

Antibiotics have the following differences:

  1. Augmentin in a suitable form of release is allowed from the first days of life. Suprax is only available to patients older than six months.
  2. Augmentin has a wider spectrum of action, for example, it can be used for whooping cough, a stomach ulcer associated with Helicobacter pylori.
  3. Augmentin should be used with caution in patients with lymphocytic leukemia and Filatov’s disease. Suprax should be used with caution in old age.
  4. Augmentin can cause a disorder of sleep, behavior, taste and consciousness, anxiety, agitation, tachycardia, crystalluria, depression, polyneuropathy. Suprax therapy may cause tinnitus, dry mouth, lack of appetite, delayed stools, flatulence, abdominal pain, and reactions that resemble serum sickness. Against the background of its administration, an increase in the concentration of bilirubin and nitrogen-containing substances, an extension of the prothrombin time can be observed.

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