Estrogel and Divigel, which is more effective

During pregnancy and lactation, it is extremely undesirable to take hormonal drugs. Such treatment is permissible only after the permission of the healthcare provider. Patients over 65 years of age should also not be treated with the described drugs. At least without proper medical examination.

If you are prone to allergies, it is advisable to choose Estrogel. Divigel has propylene glycol, which is an allergen.

More convenient to use will be Estrogel. However, Divigel’s disposable sachets will not overdo it with the product. After all, an excess of hormones can harm the body no less than their lack. Even if the drug is intended for external use.

Climax is an inevitable stage in the life of any woman. Menopause is accompanied by serious changes in the body. The production of female sex hormones is gradually decreasing. The entire process is accompanied by rather specific symptoms. For example, dryness in the vagina. Such an unpleasant sign significantly interferes with normal sexual life. Therefore, on sale you can find many tools that replace the natural lubricant. One of the most popular drugs are Estrozhel and Divigel. To understand which of them is better and for whom, you need to consider both drugs in detail.


The drug belongs to bioidentical estradiols. This is a hormonal drug. The main active ingredient is estradiol hemihydrate. In 1 g of transdermal gel contains 0.6 active component. One package in the form of a bottle of plastic with a volume of 80 grams. A convenient pump dispenser is also present. Estrogel is produced by the French company Bezen.


The main active ingredient is completely identical to estradiol produced by the female body from both a chemical and biological point of view. Estrogel has the following pharmacological properties:

  1. The provision of a powerful effect on the internal organs of the female reproductive system, which is similar to the action of hormones in the follicular phase of critical days.
  2. Compensates for the lack of estrogen during menopause, thereby reducing unpleasant manifestations: increased sweating, irritability, urinary incontinence and others.
  3. It has a procoagulant effect: it increases the production of vitamin K in the liver and reduces the content of antithrombin in the blood.
  4. Prevents a decrease in bone mass, which can trigger the development of osteoporosis.

The main indications for the use of the drug are the following conditions:

  • Substitution therapy for estrogen deficiency.
  • Treatment of menopausal syndrome due to natural or medical menopause.
  • Prevention of osteoporosis with menopause in women with an increased risk of fractures (with individual sensitivity or contraindications to taking special medications).

Hormonal drugs are considered quite serious. They affect the whole body. Ostrozhel has a number of contraindications:

  • Intolerance to estradiol or auxiliary components.
  • Oncology (including in the past).
  • Uterine bleeding with an unexplained cause.
  • Endometrial hyperplasia (in the absence of proper treatment).
  • A predisposition to thrombosis of any etiology and a lack of proteins C and S.
  • Vein thrombosis and thromboembolism. thrombophlebitis.
  • Angina pectoris and heart attack.
  • Hyperbilirubinemia of congenital origin.
  • Benign or malignant tumor processes.
  • Cholestasis.
  • Liver disease.
  • Porphyria.
  • Pregnancy and lactation.

In addition to categorical prohibitions, there are conditional ones. They mean that it is possible to conduct drug therapy, but with a great deal of caution. In the case of the described tool, it is uterine fibroids, lupus, chronic heart failure, epilepsy, bronchial asthma, renal functional impairment, atherosclerosis, ischemia, and many others. Therefore, before use, it is strongly recommended to consult a doctor.

Also, an early menopause can be attributed to contraindications. In this case, you need to contact your health care provider. The onset of menopause ahead of schedule is a pathological condition, the cause of which must be clarified.

Side effects are not ruled out. The most common are headaches, nausea, abdominal pain, chest swelling, pain in the mammary glands, increase or decrease in body weight. In other cases, bloating, skin itching, and asthenic conditions occur.

The tool belongs to the group of estrogen. Produced by the Finnish company Orion. The active ingredient is estradiol in the form of a hemihydrate. In addition to cabromer, trolamine and ethanol, divine gel contains propylene glycol. Sold in single-use sachets. In one 0.5 or 1 mg of active substance. The pack contains 28 pieces.


Pharmacological qualities are not much different from the properties of the first drug. Indications for use are the same as that of Estrozhel. An exception can only be called the use for the prevention of osteoporosis.

The list of direct and conditional contraindications is also almost identical to the previous remedy. Side symptoms also coincide.

Before choosing a particular drug for hormone replacement therapy, you should consult your doctor. Otherwise, a deterioration in health status is possible. After all, menopause itself is a huge stress for the body.

What are the drugs like?

Estrogel and Divigel have many things in common. They consist in the composition, the active component, the same indications and much more.

  • Both are bioidentical estradiol preparations.
  • Means are released in the form of a gel for external use (transdermal).
  • Both the first and second are composed of carbomer, trolamine and ethyl alcohol.
  • The drugs have almost the same spectrum of use, contraindications and side effects.
  • Estrogen can be used as a preventative measure for osteoporosis, but Divigel does not have such an item.

Despite the enormous similarities, the tools discussed have some differences. They should also be considered when buying a drug for hormone replacement therapy.

Comparison and how do they differ

If we talk about comparing Estrogel and Divigel, the difference between them is not particularly significant. However, in some cases we are talking more about convenience and safety of use.

  1. Issued by various pharmaceutical companies. The first is produced in France, and the second is made in Finland.
  2. The difference in the auxiliary components. In addition to the above, Divigel contains propylene glycol.
  3. The second is sold in single-use sachets. The first is released in a vial with a pump. It turns out, the question is in usability.
  4. If we are talking about several doses, then Estrogel is cheaper. However, the price of the vial is higher than the Divigel packaging.
  5. Due to the presence of second propylene glycol, the risk of allergic reactions increases.
  6. Estrogel is used to prevent osteoporosis, and Divigel is usually not used for such purposes.

Each organism is very individual. And if in one situation Estrogel is the best solution, then in another it will be preferable to purchase Divigel.

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