24.11.2020

Have Ketonal is a medicine against pain and inflammation

Have Ketonal is a brand name nonsteroidal anti-inflammatory drugs. In clinical practice ointment this group are used for relief of pain acute and chronic nature of various origins.

Nonsteroidal anti-inflammatory drugs attenuate the symptoms of inflammation and pain, but are developing a lot of side effects as they act in the body is not selective, and systemically. Analogs gel was Ketonal differs in that it has a more pronounced analgesic effect, causes significantly fewer negative consequences of its application to 4 – 13 %.

Pharmacological action

Have Ketonal relieves pain, inflammation, swelling. The drug blocks the enzyme cyclooxygenase-2 (COX-2), which is produced in the foci of tissue injury and regulate the formation of lipid physiologically active substances of prostaglandins – main mediators of inflammation and pain. The drug reduces the excitability of peripheral pain receptors. The gel easily penetrates into the fabric, creates the necessary therapeutic concentration.

Dosage forms

For topical (local) use is:

  • Have Ketonal cream 5 %;
  • Have Ketonal gel 2.5 %;

The drug is also available in the form of a solution for intramuscular and intravenous administration, rectal suppositories, tablets, capsules controlled release of drug for prolonged action (Ketonal DUO). It provides opportunities for the selection of treatment options in different patient situations in clinical practice.

Composition and packaging

International nonproprietary name for the drug is Ketoprofen. This is the main active agent Ketonala. The excipients depends on the form of the medicine.

Have Ketonal cream

Ketoprofen 50 mg, methyl parahydroxybenzoate, methyl ethyl ketone, propylene glycol, parahydroxybenzoate, petrolatum (white), magnesium sulfate, alpacas ST9, propylene glycol, glyceryl oleate, water.
The aluminum tube of 30 mg, 50 mg cardboard packaging.

Have Ketonal gel

Ketoprofen 25 mg, carbomer, ethanol, trolamine, lavender essential oil, purified water.
The aluminum tube of 50 mg, in a cardboard bundle.

Indications for use

Instructions for use were Ketonala from the manufacturer of the medication in the form of an ointment provides the following recommendations – symptomatic therapy (the drug is not a cure for the pathology, but effectively improves the quality of life of patients) painful and inflammatory processes of different nature:

  • periarthritis and rheumatoid arthritis;
  • ankylosing spondylarthritis, the defeat of the joints in psoriasis, reactive arthritis (Reiter’s syndrome);
  • osteoarthritis of various localization;
  • tendonitis, bursitis, radiculopathy, neuralgia, myalgia;
  • injury of musculoskeletal system (also sports), injuries of the muscles and ligaments of a different nature – sprains, bruise, break.

Testimony was Ketonala – almost all pathological processes accompanied by pain arising from stimulation of peripheral pain receptors in the skin, deep tissues and bone structures.
Have Ketonal has good anti-inflammatory action. This is a valuable feature in many diseases, especially in chronic rheumatic pathologies.

Contraindications

Hypersensitivity to Ketoprofen or auxiliary substances of the drug, to salts of salicylic acid, tiaprofenic acid, other medicines group non-steroidal anti-inflammatory drugs, fenofibrate, UV blockers, fragrances.

Clinical episodes of asthma attacks after the appointment of NSAIDs and derivatives of salicylic acid.

Pregnancy 28 – 42 weeks. In the first two trimesters appointment was Ketonala a doctor is permissible only if the expected effective action for pregnant higher perceived danger to the fetus. The gel was Ketonal contraindicated during lactation.

Children up to age 15 years.

Damaged skin is an open wound, wound infection, eczema, weeping dermatitis.

A skin hypersensitivity to ultraviolet rays.

The influence of the sun, including indirect solar radiation, ultraviolet dose exposure in a Solarium.

Method of application and dosage

A small amount of gel (3 – 5 cm) apply a thin layer 2-3 times daily to the area of pain or inflammation, RUB in gently. Be treated without medical consultation can be up to two weeks.

Side effects

The most typical undesirable effects associated with the treatment ointment on the basis of Ketoprofen, are reactions of a local nature.
Symptoms of allergic: sometimes – anaphylactic shock, angioedema.
Skin reactions:

  • erythema, eczema, burning, itching, dermatitis transient mild – rarely;
  • erythema multiforme, purpura, Stevens-Johnson syndrome, rash, photosensitivity, urticaria, bullous dermatitis, lichenoid dermatitis, skin necrosis is extremely rare;
  • one case of contact dermatitis in severe form because of the violation of hygienic rules and irradiation by solar radiation, the only case of generalized photodermatosis severe, Lyell’s syndrome (scalded skin syndrome).

Reaction respiratory: asthma attacks as a manifestation of Allergy is very rare.
Reactions of the urinary system: the kidneys in people with renal insufficiency is very rare.

Overdose

Signs of overdose are irritation, redness, itching. Shown to discontinue therapy gel and consult a doctor.

Prescription of drugs in the treatment of Ketonala

In the treatment gel was Ketonal you can’t share ointments containing Ketoprofen and its analogs. Co-administration with acetylsalicylic acid reduces the binding of Ketoprofen to plasma proteins of blood. Have Ketonal inhibits the excretion of methotrexate, increasing its toxic effects on the body.
The mutual influence on other drugs not essential.

Rules of application of the gel was Ketonal

Avoid getting the gel on the mucous membranes.

If there is any negative reaction to Ketonal, also with simultaneous use of drugs with octocrylene (included in sunscreens), immediately interrupt the treatment and consult your doctor.

Do not increase the dose of the gel, if you have forgotten it in time to apply.

For the effective action of Ketonal combine in different medicinal forms: ointments and suppositories, capsules, tablets. The total dosage during the day all forms of medication should not exceed 200 mg. In acute severe pain preferred step therapy.

In the instructions for use were Ketonala recommended to protect the skin, to which was affixed the gel with clothing during treatment and 15 days after the end of the course.

In the treatment of Ketonala in the form of gel contraindications apply an occlusive (airtight) dressings.

The drug does not affect the decrease in the concentration of attention and speed of psychomotor reactions.

Ketonal have is over-the-counter drug. Made in Slovenia (holder of the registration certificate) and Germany.

Distinctive features were Ketonala

Chemical affinity for organic substances, relatively small size of the molecule and the low molecular weight of Ketoprofen determine its ability to easily penetrate tissue barriers. The drug has a pronounced effect on the receptors responsible for pain sensitivity.

Significant superiority of Ketoprofen over analogs in patients with rheumatic pathologies of different nature is proved generalizing repeated clinical studies. The drug shows higher indicators for the improvement of health through the week compared to other medications of its group.

Ketoprofen has a relatively favorable safety profile in relation to the negative effect of non-steroidal anti-inflammatory drugs on the gastrointestinal tract, the complications of the cardiovascular system during the appointment are rare.

The gel has a low level of toxicity.

Analogues of the drug

None of the modern non-steroidal anti-inflammatory drugs cannot be considered perfect. Each of them has its contraindications and side effects. Including and Ketonal. If a drug demonstrates an advantage on a certain action, most likely, it will be and cons of using.

The main parameters which should be taken into account when choosing analogues of the drug – the severity of the analgesic and anti-inflammatory effects, ease of use and the risk of complications in the digestive system, cardiovascular system.

When used in therapeutic doses, the performance of all non-steroidal anti-inflammatory drugs are essentially the same if we are talking about the long course of treatment. But with a relatively short-term use of these drugs, especially in the case of the relief of acute pain, when it has the value of the speed of onset of clinical effect, some of the members of the group can demonstrate a definite advantage due to its pharmacological characteristics.

Analogues were Ketonala – diclofenac, piroxicam, aceclofenac, ibuprofen, naproxen, indomethacin, nimesulide, Fastum.

Attention! The pain may be caused by infectious processes in the body, disorders of metabolism, tumors. Description of the preparation is simplified and augmented version of the official instructions for use. Have Ketonal must appoint a physician after a survey and examination of the patient. Information about the drug provided solely for informational purposes and should not be used as a guide to self-healing.

International nonproprietary name The trade name of the drug Price Release form Manufacturer
Ketoprofen Have Ketonal 237 RUB. The 5% cream, 30 g Slovenia
Ketoprofen Have Ketonal 303 RUB. The 5% cream, 50 g Slovenia
Ketoprofen Have Ketonal 319 RUB. Gel 2.5 %, 50 g Slovenia
Ketoprofen Fastum 335 rubles Gel 2.5% 50g Germany
Piroxicam Finalgel 271 RUB. The gel of 0.5%, 50 g Germany
Diclofenac VOLTAREN EMULGEL 338 RUB. Gel 1%, 50 g Germany
Diclofenac Diklak 234 RUB Gel 5%, 50g Germany
Aceclofenac Aerial 277 RUB. Cream of 1.5%, 60 g Hungary
Ibuprofen First days without 136 RUB. The 5% cream, 50 g Germany
Naproxen Naproxen 1380 RUB Gel 10%, 50 g Poland
Indomethacin Indomethacin 58 RUB. Ointment 10 %, 40 g Bulgaria
Nimesulide Nimesulide 177 RUB. Gel 1%, 20,0 g Russia

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