De Nol or Nolpaza, which is more effective

Both drugs are prescribed for gastric ulcer and gastritis. They actively fight Helicobacter pylori, and also protect the gastric mucosa from unwanted effects.

It is impossible to say unequivocally which of the drugs is more effective. The drugs belong to different pharmacological groups and their mechanism of action is also different. De-Nol has an enveloping effect that allows you to protect the gastric mucosa. Nolpase is effective for gastritis with high acidity.

The price of De Nol is 500-1000 rubles. The price of Nolpaza is 130-700 rubles (depending on the dosage and number of tablets).

The course of treatment with De-Nol is significantly longer than treatment with Nolpaza.

De Nol has the following advantages:

  • It has a complex therapeutic effect.
  • Allowed for children from 4 years.
  • It has a pronounced effect on Helicobacter pylori.
  • It has few side effects.

Nolpaza has these advantages:

  • High bioavailability.
  • Affordable price.
  • It inhibits the production of hydrochloric acid.
  • It is allowed to take for the prevention of peptic ulcer.

Also, drugs can be taken in one regimen with combination therapy. This requires specialist advice. However, in general, medications are compatible. This is usually necessary for exacerbation of gastric ulcer. At such a moment, not only an antibacterial effect is necessary, but also a decrease in the acidity of the stomach. This treatment regimen can only be prescribed to adults under the supervision of a specialist.

Thus, both drugs are effective in the treatment of diseases of the gastrointestinal tract. It is impossible to say unequivocally which of the drugs is better, since their mechanism of action is different. The treatment regimen and specific medication should be selected by the doctor individually for each patient. The simultaneous use of both drugs is also possible, but only under the supervision of a physician. Self-medication is not recommended.

Gastrointestinal problems are diagnosed in many people. Stress, malnutrition and other factors lead to such diseases. In the treatment of peptic ulcer and gastritis, the specialist prescribes complex treatment. It includes ulcerative drugs, anti-inflammatory, antibiotics and many others. Often appointed De Nol and Nolpaza. Sometimes patients have a question which one is better. To do this, you need to consider them in more detail.

De nol

A drug belonging to the group of gastroprotectors. The active substance is bismuth. It has antibacterial, anti-inflammatory and antiulcer effects. Available in tablet form.

When using the drug in the stomach, a protective film is created that prevents the effects of the acidic environment on the mucous membrane.

De nol

The main distinguishing feature of the drug is that to date, not a single Helicobacter pylori strain has been identified that would not be sensitive to this drug. The substance dissolves well, which allows you to penetrate even under a large layer of mucus and destroy microorganisms.

Indications are:

  • Gastrointestinal ulcer.
  • Gastritis.
  • Erosion.
  • Gastroduodenitis.
  • Dyspepsia.
  • Pancreatitis
  • Irritable bowel syndrome.

Apply De-Nol is contraindicated:

  1. With renal failure.
  2. Pregnant and lactating women.
  3. Children under 4 years old.
  4. People with hypersensitivity to the components.

Side effects:

  • Dyspeptic disorders.
  • Allergic reactions.
  • With prolonged use, there is a risk of developing encephalopathy.

Patients older than 12 years per day should take 4 tablets. You can take 1 tablet 4 times a day or 2 tablets 2 times a day. It is necessary to take 30 minutes before a meal, drinking plenty of water.

For children from 4 to 12 years, the amount of the drug is calculated according to the formula 8 mg / kg per day. Based on this, the daily dose for a child can be 1-2 tablets.

The duration of treatment is 4-8 weeks. After completion for eight weeks, it is not recommended to take preparations containing bismuth.


The drug belongs to the pharmacological group of proton pump inhibitors. The active substance is pantoprazole. Available in tablet form.


The active substance prevents the production of hydrochloric acid, which protects the mucous membrane from destruction. When applied, the substance quickly spreads through the circulatory system. Bioavailability of 77%, does not depend on food intake. The maximum concentration is observed 2-2.5 hours after administration.

Indications are:

  • Exacerbation of peptic ulcer of the stomach and duodenum.
  • Gastritis caused by taking non-steroidal anti-inflammatory drugs.
  • Gastroesophageal reflux disease.
  • Conditions in which there is an increased acidity in the stomach.

It can also be taken as a prophylaxis to protect the stomach from peptic ulcer at the time of taking non-steroidal anti-inflammatory drugs.

Contraindications are:

  • Hypersensitivity to substances.
  • Pregnancy and breastfeeding.
  • Kidney disease.
  • Children under 18 years old.
  • Liver failure.
  • Disorders of the stomach and intestines against a background of neurosis.
  • Violation of the absorption of vitamin B12.
  • Fructose intolerance.

Usually, taking the drug does not cause side effects. However, in rare situations, they may occur. Side effects are manifested in the following:

  1. Dyspeptic disorders (constipation, diarrhea, nausea).
  2. Dizziness, headache.
  3. Swelling.
  4. Allergic reactions (urticaria, Quincke edema).
  5. Muscle pains.

The agent is administered orally. The tablet should be swallowed without chewing and washed down with a sufficient amount of water. It is recommended to take before meals. Usually 1 tablet per day is prescribed. In this case, it is better to take it in the morning.

Leave a Reply

Your email address will not be published.