Salofalk granules or Salofalk tablets, which is more effective

Contain one active substance with various proportions. Some side effects. The action is carried out at the local level – the submucous layer of the intestine, from the side of its lumen. This allows the main substance to penetrate to the inflamed area. Resistance to gastric juice was noted. The dissolution rate of the drug is not affected by the changing pH environment.

The action of the granules is prolonged, that is, it is carried out for a long time by accumulation. The tablets are effective for 17 hours. Granules are used more for the prophylactic purposes of ulcerative colitis and Crohn’s disease. Tablets – in the stage of exacerbation of these diseases.

Nonspecific ulcerative colitis, Crohn’s disease cause pathological changes in the intestinal mucous membranes. To make an accurate diagnosis and keep patients under control, a number of diagnostic measures and complex treatment are required.

On the positive side, the drug Salofalk, produced in granules and tablets, has proven itself. In order for the consumer to give preference to one of them, it is necessary to clarify the features of each form of release.


The drug Salofalk is produced in Germany. It is provided in the form of granules, tablets, suppositories, enemas. The main active ingredient is mesalazine. The main therapeutic effect: anti-inflammatory, antimicrobial. It is carried out at the intestinal level. The drug is used in the treatment of Crohn’s disease and UC.

The anti-inflammatory property is provided by mesalazine, which is also called 5-aminosalicylic acid. The substance affects inflammatory mediators. Acts as an antioxidant.

Penetrating into the distal colon, small intestine, mesalazine is released from the dosage form. 43% bound to plasma proteins. For half an hour, it is metabolized in the intestinal mucosa and liver. It is excreted by the urinary system in acetylated form.

The drug is prescribed only under the supervision of the attending physician. Before, during, after treatment, the specialist will follow the indications of AK and AM, which will show how the kidneys function. This is especially true for patients with kidney disease.

Salofalk rarely causes adverse reactions, but you need to know about them:

  • Hematopoietic system: a change in blood composition (extremely rare).
  • CNS: headache with episodes of dizziness (rarely); peripheral neuropathy (extremely rare).
  • Gastrointestinal tract: pain accompanied by diarrhea, nausea, vomiting, flatulence (rare).
  • Urinary system: OKHIN, renal failure (extremely rare).
  • Skin: alopecia (extremely rare).
  • Musculoskeletal system: myalgia, arthralgia (extremely rare).
  • Reproductive system: reversible oligospermia (extremely rare).

The immune system can react with various rashes, bronchospasms, drug fever.

No cases of overdose have been reported. For intoxication, an intravenous infusion of electrolytes should be used.

Advantages of the drug: it is produced in various forms. Each of them has its own characteristics.

Sustained-Release Granules

The grayish-white color of the granules is in the form of a cylinder or ball. Top coated with a membrane soluble by intestinal enzymes. Placed in laminated bags of aluminum foil. One contains: 500 mg, 1 g, 1.5 g, 3 g of the main substance. 50 bags per pack.


The size of the granules (1 mm) contribute to their smooth movement from the stomach to the intestines. If transit occurs simultaneously with food intake, the speed may slow down for several hours.


Each unit is coated with a soluble intestinal flora. Color varies from yellow to brown, light tones. The shape of the dauya is convex, smooth.


The main active ingredient is mesalazine. One tablet holds 250 mg (round in appearance) or 500 mg (oblong in appearance). Packing – blisters. Cardboard packaging holds 5 or 10 blisters.

The dissolution of 250 mg tablets is carried out at the level of the ileum for 4 hours, provided that food is consumed. The main substance reaches the colon after 7 hours.

Dissolution of tablets of 500 mg is carried out at the level of the ileum for 4 hours. The therapeutic effect is carried out in the descending colon after 5 hours.

In which case use this or that form

Salofalk granules are contraindicated in patients with serious kidney pathologies, since mesalazine causes a nephrotoxic effect.

Patients with bronchial asthma are closely monitored during the treatment with Salofalk granules and tablets.

Patients in whom sulfasalazine caused adverse reactions should be observed by a specialist, especially at the beginning of treatment with the drug. In the presence of: seizures, severe abdominal pain, rash, headache, fever, – the drug (of any form) is canceled.

Granules contain aspartame sweeteners – this is important for patients with phenylketonuria.

Caution is prescribed to women planning a pregnancy, 1 trimester of pregnancy. Prohibited in the last month of pregnancy. During lactation, a doctor’s consultation is necessary.

The main indications of Salofalk capsules: exacerbation of ulcerative colitis of medium and mild distal intestines; long-term therapy to maintain a remission of these conditions.

The drug can not be used by patients who have: hypersensitivity to salicylic acid derivatives; renal / liver failure; stomach / duodenal ulcer; hemorrhagic diathesis. Do not assign a child category up to 6 years.

The main indications of tablets: prevention, treatment of Crohn’s disease; treatment of ulcerative colitis.

The form of the drug can be prescribed by the attending physician, which will take into account the patient’s condition and stage of the disease.

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