Ascoril and Prospan have different composition, contraindications and undesirable reactions, therefore, it is better to decide what the doctor should do, depending on the patient’s health status, age, tolerance to therapy.
A cough can accompany many colds. To eliminate it, the medicines Ascoril and Prospan are used. These drugs are not cheap, so for many patients it is important to know which of the medicines is better for coughing.
Ascoril is a combination agent that contains salbutamol, guaifenesin, and bromhexine as the main substances .
The medication is produced in 2 dosage forms:
- Tablets. They are white, round, flat, have a bevel and at risk. As additional components they contain E216, E218, maize starch, aerosil, E576, E553b, calcium hydrogen phosphate.
- Syrup. It is a clear, orange, viscous liquid that has a specific smell. The syrup contains sucrose, sorbitol, glycerol, macrogol, fragrance pineapple and blackcurrant, water, menthol, E330, E200, E110, sodium benzoate as indifferent components.
The therapeutic effect of the drug is explained by its main components:
- Salbutamol expands the bronchi, increases the vital capacity of the lungs.
- Bromhexine is a mucolytic, helps sputum discharge.
- Guaifenesin facilitates the evacuation of bronchopulmonary secretions, promotes the transition of dry cough to wet.
Salbutamol after oral administration is rapidly absorbed, its bioavailability is 50%. Up to 10% of the accepted dosage binds to proteins. Salbutamol crosses the placenta, is metabolized in the liver, excreted mainly in the urine. The half-life can vary from 3.8 hours to 6 hours.
Bromhexine is adsorbed from the digestive tract for half an hour. It crosses the placenta, is metabolized in the liver, excreted in the urine, with kidney pathologies it can accumulate, the elimination half-life is 15 hours.
Guaifenesin is absorbed from the digestive tract for 30 minutes, metabolized in the liver, excreted in the urine and through the lungs, half-life is 1 hour.
Prospan contains ivy as the main component. The medicine is available in 2 forms:
- Drops for oral administration and inhalation. They are a dark brown liquid that smells like alcohol and fennel. They include water, anise oil, fennel and peppermint, sodium saccharinate as auxiliary components.
- Syrup. It is a light brown, slightly turbid liquid that smells of cherry. As inactive components, it contains E202, E330, xanthan gum, sorbitol, and cherry fragrance.
Phytopreparation expands the bronchi, helps discharge difficult sputum.
What are similar drugs
Ascoril and Prospan have the following similarities:
- Medicines are used for diseases accompanied by cough with sputum that is difficult to separate.
- Medications should not be drunk by women in position or breastfeeding.
- In a suitable form of release, drugs are allowed from birth.
- Expectorants should not be drunk simultaneously with medicines that suppress cough, since in this case sputum will stagnate in the lungs, which serves as a good medium for the reproduction of microorganisms.
- Drugs can not be drunk with hypersensitivity to their composition, otherwise they can cause an allergic reaction.
Comparison, differences and which is better
Ascoril and Prospan have the following differences:
|Release form||Syrup, tablets.||Syrup for oral administration, drops for oral administration and inhalation.|
|Shelf life||The shelf life of Ascoril, regardless of the dosage form, is 24 months.||Drops are suitable for 4 years. The syrup is suitable for 3 years, but after opening the bottle, the medicine can be used only for 3 months.|
|Terms of sale||Prescription.||OTC.|
|Contraindications||Ascoril is contraindicated in liver and kidney dysfunction, peptic ulcer, gastrointestinal bleeding,
tachyarrhythmias, inflammation and heart defects, uncompensated diabetes mellitus, hyperthyroidism, high intraocular pressure. Tablets should not be drunk with hypertension. With caution, the medicine should be drunk with a history of digestive tract ulcers and diabetics.
|Drops inside cannot be drunk at pathologies at which ethyl alcohol is forbidden.
Inhalations can not be done to asthmatics, people prone to laryngospasm.
Drops with caution should be drunk with liver dysfunction, head injuries, brain pathologies.
Inhalation should not be done to patients under 2 years of age, since there is a high probability of laryngospasm.
|Unwanted effects||Cephalgia, dizziness, excessive irritability, sleep disturbance, trembling of parts of the body, cramps, nausea, loose stools, vomiting, exacerbation of a gastrointestinal ulcer, tachycardia, collapse, bronchospasm, staining of urine in pink.||Due to the sorbitol content, the medication can cause diarrhea.|
|Overdose||Strengthening adverse reactions. There is no specific antidote, the treatment is symptomatic.||Nausea, vomiting, diarrhea. The antidote is unknown, symptomatic therapy.|
|Drug interaction||Due to salbutamol, which is part of Ascoril, it is not recommended to drink it together with MAO inhibitors. Theophylline, diuretics, corticosteroids, and other β2-adrenergic agonists enhance the effects of salbutamol and increase the risk of adverse reactions.
Bromhexine facilitates the penetration of antimicrobials into the lungs.
Along with treatment with Ascoril, alkaline drinking and taking non-selective β-adrenergic blockers are not recommended.
|Effect on ability to drive a car||Drivers need to be careful when using the medicine.||Does not affect.|