20.10.2020

Bisoprolol and Bisoprolol Prana, drug choice

Bisoprolol and Bisoprolol Prana are interchangeable and after consultation with a doctor, anyone can be taken.

Both medications are sold by prescription, therefore it is forbidden to drink them on their own, as this can provoke the progression of the pathology.

To treat arterial hypertension, Bisoprolol and Bisoprolol Prana medicines are used. Let’s try to figure out how these tools differ.

Bisoprolol

Bisoprolol is available in tablets by several companies, so they may differ in the composition of inactive components. The drug is on sale in dosages of 2.5 / 5/10 mg.

Bisoprolol

Bisoprolol is a selective β1-blocker . How it works at high pressure is not completely clear. The medicine lowers renin activity in the body and blood pressure, oxygen demand of the heart muscle, reduces heart rate, has antiarrhythmic and antianginal effects.

On the first day, OPSS rises, then normalizes within 3 days, and then begins to decline.

A decrease in pressure occurs within 5 days after the start of therapy, and a stable effect develops after 1 or 2 months of treatment .

After oral administration, the active substance is rapidly absorbed from the digestive tract, bioavailability is 90% . In the liver, it is metabolized. Up to 30% of a single dosage interacts with proteins. The highest concentration of the drug is achieved 2-3 hours after oral administration. The half-life can vary from 10 to 12 hours. Pills are removed in equal amounts through the kidneys and intestines.
Bisoprolol prana

The drug is produced by Pranafarm LLC in tablets of 2.5 mg, 5 mg and 10 mg. Tablets of 2.5 mg are round, white, biconvex, on the cut you can see the white core.

The drug in a dose of 5 mg and 10 mg is available in round, biconvex tablets. They are at risk. 5 mg tablets are pale yellow, 10 mg orange, with a white core inside.

Bisoprolol prana

Regardless of dosage, the preparation contains the following formative ingredients:

  • MCC.
  • E383.
  • Maize starch.
  • E576.
  • Crospovidone.
  • Aerosil.

The shell is formed by propylene glycol and titanium white, in addition to them, 2.5 mg tablets contain dimethicone, 5 mg each – iron oxide yellow, 10 mg each – iron oxide red.

The drug lowers high blood pressure, slows down and normalizes the heart rhythm, reduces the need for myocardium in oxygen.

Bisoprolol and Bisoprolol Prana have the same mechanism of action, pharmacokinetics and pharmacodynamics.

What is anuria

Similarities of funds

Bisoprolol and Bisoprolol Prana tablets are used to treat the following pathologies:

  1. High pressure.
  2. Chronic heart failure.
  3. Ischemic heart disease, for the prevention of angina attacks.

Both drugs are contraindicated if observed:

  • Allergies to the composition of the drug and other β-blockers.
  • Heart failure in the acute phase.
  • Uncompensated heart failure, which requires inotropic treatment.
  • Shock.
  • SSSU.
  • Heart rate less than 60 beats per minute.
  • Pulmonary edema.
  • Atrioventricular and sinoatrial block.
  • Hypotension.
  • Severe bronchial asthma and cold.
  • Lowering blood pH.
  • Severe peripheral circulation disorders.
  • Pheochromocytoma, if the patient does not receive α-blockers.

These medicines should not be taken by women who are breastfeeding, children, or patients receiving MAO inhibitors, except for type B MAO blockers.

With caution, Bisoprolol and Bisoprolol Prana should be drunk by the elderly, those on a strict diet, receiving desensitizing therapy, as well as in the presence of the following deviations:

  1. Hyperthyroidism.
  2. Depressive state.
  3. CHF with myocardial infarction over the past 3 months.
  4. Severe heart defects.
  5. Scaly lichen.
  6. Severe liver and kidney disease.
  7. AV block 1 stage.
  8. Spontaneous angina pectoris.
  9. Juvenile and uncompensated diabetes.
  10. Restrictive cardiomyopathy.

Both medicines can provoke a number of undesirable reactions:

  • Bradycardia, hypotension, angiospasm, AV block, heart rhythm disturbance, chest pain, progression of heart failure with the appearance of edema.
  • Vertigo, headache, weakness, insomnia, depression, impaired consciousness, short-term amnesia, hallucinations, muscle weakness, cramps, trembling of certain parts of the body.
  • Visual disturbances, decreased tear fluid, ringing and pain in the ears, hearing loss, taste perversion, dryness and pain in the eyes, inflammation of the conjunctiva.
  • Bronchospasm, allergic rhinitis, nasal congestion.
  • Nausea, vomiting, upset stomach, stool retention, dry mouth, abdominal pain, inflammation of the liver, increased levels of bilirubin, triglycerides, and liver enzyme activity.
  • Joint pain.
  • Weakening of sexual desire, erectile dysfunction.
  • Decreased platelet and white blood cell counts.
  • Itching, rash, urticaria.
  • Excessive sweating, redness of the skin.
  • Hair loss.
  • Exacerbations of psoriasis.
  • Cancellation syndrome, which is manifested by an increase in angina attacks and an increase in blood pressure.

If therapeutic doses are exceeded, both medicines can provoke the following signs of an overdose:

  • Heart rhythm disturbance.
  • Strong decrease in heart rate.
  • AV blockade.
  • Severe hypotension.
  • Glucose drop
  • Cyanosis of the skin.
  • Respiratory failure.
  • Bronchospasm.
  • Vertigo.
  • Fainting.
  • Cramps.

With an overdose of these medicines, the antidote is unknown. It is necessary to cancel the medicine, rinse the affected stomach, give an adsorbent to drink, and carry out symptomatic therapy.

Comparison and how do they differ

There are the following differences between Bisoprolol and Bisoprolol Prana preparations:

Bisoprolol Bisoprolol prana
Manufacturer The drug is produced by several companies, for example, Vertex JSC, Atoll LLC. Pranapharm LLC, Russia.
Shelf life Shelf life may vary by company. For example, tablets of Borisov Plant of Medicines OJSC are valid for 24 months, and the medicine manufactured by Atoll LLC has a shelf life of 36 months. 36 months.
Cost The cost of the drug may vary significantly depending on the manufacturer. The price can vary from 30 to 270 rubles. The price depending on the dosage can vary from 30 to 60 rubles.

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