Clotrimazole or Nystatin, the choice of drug

It is impossible to say unequivocally which antimycotic agent. Only a doctor should select an antifungal drug after determining the sensitivity of the pathogen to the medication.

Self-medication with antimycotics is unacceptable, since this can cause the progression of the disease, in addition, it must be borne in mind that due to the use of medicines, a number of undesirable effects may occur.

Clotrimazole in vaginal tablets may cause:

  1. Abdominal pain.
  2. Unpleasant sensations, redness and swelling in the vulva and vagina.
  3. Headache.
  4. Bladder inflammation, private urination.
  5. Excretions from the genital tract.
  6. Burning, irritation, itching, pain in the pelvic area.
  7. Burning in the penis of a sexual partner.
  8. Pain during intimacy.

With external use, clotrimazole can cause itching, burning and tingling at the site of application, redness, blisters, swelling, peeling and irritation of the skin.

If doses of clotrimazole are exceeded during vaginal administration, nausea, vomiting, and dizziness may occur. With external application, antimycotic poisoning is unlikely.

If you accidentally take clotrimazole inside, the following signs of intoxication can be observed:

  • Refusal of food.
  • Nausea.
  • Vomiting
  • Abdominal pains.
  • Liver dysfunction.
  • Drowsiness.
  • Increased urination.
  • Hallucinations.

The antidote is unknown, therefore symptomatic therapy is prescribed.

Nystatin tablets may cause:

  • Nausea.
  • Vomiting
  • Stomach upset.
  • Abdominal pains.

Ointment can cause itching. Treatment with rectal suppositories can trigger loose stools and abdominal pain. Regardless of the form of release, nystatin can cause fever and chills.

The pharmacy offers a wide range of antifungal agents and it is not always easy for a person to understand it without a medical education. Let’s compare what is better with clotrimazole or nystatin.


Clotrimazole is on sale in the form of vaginal tablets, a solution for topical and topical use, a gel and an ointment. The medication is produced by several domestic and import companies.


Depending on the concentration, the antimycotic can stop the growth and reproduction of fungi or cause their death.

The active substance binds the phospholipids of the cell membrane as a result of which the permeability of the cell membrane of the fungus changes. It affects the biosynthesis of ergosterol, inhibits the formation of proteins, lipids, DNA, polysaccharides in pathogenic agents, accelerates the excretion of potassium from them. All this leads to a suspension of the growth of pathogens and their death.

Sensitive to antimycotics:

  • Dermatophytes.
  • Yeast-like and dimorphic mushrooms.
  • Trichomonads.
  • Streptococci.
  • Staphylococci.
  • Protei.
  • Salmonella.

Mushrooms that are resistant to clotrimazole are rare.

After administration to the vagina, only 3% to 10% of a single dosage is absorbed . With external use, clotrimazole penetrates poorly through the skin and mucous membranes. In the liver, the drug is metabolized. It is excreted with urine and feces.

Vaginal tablets are used:

  • With vaginitis, the causative agent of which are fungi of the genus Candida, including those caused by strains resistant to nystatin.
  • For the rehabilitation of the birth canal before childbirth.

The solution, ointment and gel are used for the following diseases:

  1. Mycoses of the skin, including those complicated by a bacterial infection.
  2. Erythrasma
  3. Pityriasis versicolor.

Nystatin is available in tablets for oral administration, in the form of ointments, rectal and vaginal suppositories.

The medicine is made by several companies, so the composition of its additional components may vary.


Nystatin is a polyene antimycotic antibiotic. It is active against fungi of the genus Candida. It changes the membrane permeability of the pathogen wall for electrolytes, which causes the death of the infectious agent. Resistance in fungi to nystatin develops slowly.

Antimycotic is poorly absorbed from the digestive tract, is not adsorbed through the skin. The medicine is excreted in the feces.

In tablets, nystatin is prescribed for the treatment and prevention of digestive tract dysbiosis.

Ointment is used to treat and prevent mycosis of the skin, which is caused by fungi of the genus Candida.

Vaginal suppositories are used for vaginal thrush. Rectal suppositories are used to treat and prevent rectal mycosis.

What is common between drugs

Clotrimazole and Nystatin have the following similarities:

  1. Both antimycotic agents, depending on the concentration, can have fungistatic and fungicidal effects.
  2. Both medicines can be used by drivers without any restrictions.
  3. Antimycotics can not be used with intolerance to their composition, in which case they can cause allergies.
Comparison and differences

Clotrimazole and nystatin have the following differences:

Clotrimazole Nystatin
Release form Vaginal tablets, cream, gel, solution for external use. Tablets, ointment, vaginal and rectal suppositories.
Pediatric Use Cream, gel, solution can be from 2 years old, vaginal tablets from 12 years old. Nystatin tablets can be used from 3 years, the rest of the medicines are not recommended for children.
Use during pregnancy Regardless of the form of release, the drug is contraindicated in the first trimester. Forbidden to women in position.
Use during lactation The medication is allowed for women who support breastfeeding. Tablets are prohibited during lactation.
Sale Rules Without a prescription. On prescription.
Contraindications Vaginal tablets cannot be inserted during menstrual bleeding. Tablets are prohibited for pancreatitis, gastrointestinal ulcer, liver dysfunction. With caution, they should be drunk with kidney pathologies and a decrease in the number of leukocytes.
Drug interaction Nystatin, amphotericin B, natamycin with simultaneous use weaken the effect of clotrimazole.

Clotrimazole with vaginal use damages contraceptives containing latex, so within 5 days after treatment, other methods of protection from unwanted pregnancy should be used.

If a woman receives tacrolimus, then clotrimazole, when introduced into the vagina, can cause an increase in the level of immunosuppressant and an overdose of it.

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