22.10.2020

Corinfar or Kapoten, the choice of drug

Corinfar and Kapoten are not complete analogues, each medication has its own peculiarities, therefore, a doctor should decide which antihypertensive agent is better, taking into account the patient’s state of health.

Pharmaceutical companies offer a wide range of drugs for the treatment of hypertension. These include Corinfar and Kapoten. Despite the general indications for use, medications have many differences that you need to know before starting a course of therapy.

Corinfar

Corinfar is available in prolonged round, biconvex, yellow tablets. They contain nifedipine as a therapeutic component.

Corinfar

In addition to it, the composition of the medicine includes:

  • Milk sugar.
  • MCC.
  • Potato starch.
  • E576.
  • Povidone K25.
  • Propylene glycol.
  • Titanium white.
  • E104.
  • E553b.
  • Hypromellose.

Nifedipine is a selective calcium channel blocker . The drug has an antianginal and hypotensive effect, enhances blood supply in the kidneys and heart muscle, does not cause the phenomenon of “robbery”. The drug dilates the arteries, does not affect the tone of the veins. During therapy, the total peripheral vascular resistance, afterload, cardiac muscle tone, and its oxygen demand decrease.

The clinical effect after ingestion develops after 20 minutes, its duration in time takes from 4 to 6 hours. If the drug is drunk for 2-3 months, then it becomes addictive.

When ingested, up to 90% of the drunk dosage is absorbed . Bioavailability can vary from 50% to 70%, but with food it increases. In the liver, the drug is metabolized. The highest concentration after ingestion is achieved after 1-3 hours. Up to 95% of the drunk dosage binds to proteins.

The medication penetrates the placental and blood-brain barrier, is secreted through the mammary glands. Up to 20% is excreted through the intestines, the rest through the kidneys. The elimination half-life can vary from 2 to 5 hours , in patients with liver dysfunction it increases to 20 hours.

Protein in urine in pregnant

Kapoten

The drug is available in square tablets that have rounded edges. They are biconvex, on one side there is a cruciform notch. Slight marbling is allowed.

Kapoten

As an active ingredient, the medication contains captopril . In addition to it, the composition of the medicine includes inactive components:

  • MCC.
  • Milk sugar.
  • Maize starch.
  • Stearic acid.

Captopril is an ACE blocker . The drug suppresses the synthesis of angiotensin II, which causes vasoconstriction and increased blood pressure.

After taking captopril, afterload and OPSS, the production of aldosterone in the adrenal glands decreases. The maximum decrease in pressure is observed after 1-1.5 hours .

Captopril is rapidly adsorbed from the digestive tract, the highest concentration is noted after an hour. Bioavailability in different patients can vary from 60% to 70%. Up to 30% of the accepted dosage binds to blood proteins. Captopril is removed from the body mainly through the kidneys; the half-life varies from 2 to 3 hours .

Similarities of funds

Corinfar and Kapoten have the following similarities:

  1. Both medicines are used to treat hypertension and chronic heart failure.
  2. Antihypertensive drugs are prohibited for patients who support breastfeeding.
  3. Store both drugs at temperatures up to 25 degrees for 5 years from the date of issue.
  4. During therapy with antihypertensive drugs, care must be taken when driving vehicles and working with mechanisms that can be potentially dangerous.
  5. Medicines can not be drunk with intolerance to their composition, narrowing of the mouth of the aorta.
  6. While taking both medicines, there may be a decrease in all blood cells, a disturbance in heart rhythm, a drop in blood pressure, hot flashes, muscle and joint pain, an increase in daily diuresis and mammary glands, liver and kidney dysfunction, swelling of the extremities, blurred vision, dizziness, headache, drowsiness, depression, bronchospasm, pulmonary edema, gingival hyperplasia, dry mouth, diarrhea, nausea, vomiting, powerlessness.
Comparison and differences

Corinfar and Kapoten have the following differences:

Corinfar Kapoten
Manufacturer country Israel. Russia.
Use during the period of bearing a child The drug is contraindicated in the first trimester, at a later date, the medication should be drunk with caution. The medicine is prohibited for pregnant women.
Indications for use Corinfar is used for variant angina pectoris. The drug can be drunk in case of damage to the kidney tissue caused by type I diabetes mellitus, with left ventricular hypertrophy provoked by myocardial infarction, but only if the patient’s condition is clinically stable.
Contraindications The medicine can not be drunk at low pressure, decompensated heart failure, cardiogenic shock, collapse, unstable angina, within a month after myocardial infarction, simultaneously with rifampicin. With caution, nifedipine should be taken with mitral valve stenosis, severe reduction or increase in heart rate, hypertrophic obstructive cardiomyopathy, sinus node weakness, malignant arterial hypertension, severe circulatory disorders in the brain, decreased circulating blood volume, digestive tract obstruction, liver function, myocardial infarction, accompanied by left ventricular failure. With caution, it should be prescribed in combination with digoxin and β-blockers, as well as patients who are on hemodialysis. The drug is prohibited for liver and kidney pathologies, a high level of potassium in the blood, narrowing of the renal arteries, after a kidney transplant. It should not be drunk to diabetics and patients with renal dysfunction if they receive drugs containing aliskiren. With caution, the medicine should be drunk in case of severe autoimmune pathologies, suppression of bone marrow function, Conn syndrome, central nervous system ischemia, diabetes mellitus, coronary heart disease, hypovolemia, liver and kidney dysfunction, heart failure, elderly people and African Americans, hemodialysis patients and following a salt-free diet.
Pediatric Use Children should take the medicine with caution. Only adults can drink.
Corinfar can cause myocardial infarction, bloating, increased blood sugar, appetite and weight, cramps, and parkinsonian disorders. Kapoten can cause Raynaud’s syndrome, pallor, cardiac arrest, dry cough, cardiogenic shock, dyspnea, runny nose, hair loss, eosinophilic pneumonitis, sleep disturbance, sensitivity and cerebral circulation, autoimmune pathologies, irritation of the gastric mucosa, abdominal pain, taste perversion, from food, stomatitis, glossitis, stomach ulcers, pancreas inflammation, increased bilirubin, erectile dysfunction, chest pains, fever and lower sugar levels.

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