22.10.2020

Irunin or fluconazole, the choice of drug

The treatment of various types of mycoses is potentially effective both by Irunin and Fluconazole. However, the duration and quality of treatment of diseases of different etiologies may vary.

Irunin is recommended for:

  • Treatment of adults and children over 4 years old.
  • Treatment of pregnant women and women during lactation – in exceptional cases that pose a threat to life and health.
  • Mycosis of mild to moderate degree, when lesions are localized on the surface of the skin, its derivatives and mucous membranes.

Fluconazole is recommended for:

  • The treatment is for children over 4 years old and adults, excluding the period of pregnancy and lactation.
  • Various types of mycoses, especially severe systemic lesions, as well as immunodepressions of various types as maintenance therapy and prevention.

As clinical practice shows, Irunin preparations are more suitable for the treatment of common fungal lesions of the body surface, oropharynx, inguinal region, as well as during pregnancy and lactation, if there is an urgent need. Fluconazole is suitable for acute and deep severe mycoses that affect the blood, lungs, heart and other organs and is completely contraindicated during pregnancy and lactation.

Irunin and Fluconazole are antifungal drugs of the azole group , which have proven their effectiveness in practice. Similar, at first glance, preparations, some nevertheless have a number of distinctive features, which can become a good criterion for selection.

Irunin

Irunin is a drug with a wide effect on a number of representatives of pathogenic fungal flora:

  • Dermatophytes – eating keratin proteins on the keratinized layer of the epidermis of various parts of the body. Includes diseases such as microsporia, trichophytosis and epidermophytosis.
  • Yeast-like fungi – inhabiting the mucous membranes. Normally, they are saprophytic, they can acquire pathogenic properties in conditions of decreased immunity.
  • Yeast fungi are constantly present in the intestines and are conditionally pathogenic.

Irunin

Available in two forms: capsules for oral administration and tablets for vaginal.

The main active ingredient is itraconazole , the content of which in capsules is 100 mg , and in tablets – 200 mg . The mechanism of action: inhibition of the production of ergosterol – an important component of the cell wall of the fungus. Auxiliary components of the drug in capsules:

  • Hydrating – hypromellose.
  • The components of the protective coating are eudragit.
  • Preservatives – nipagin, nipazole (effective against mold fungi).

In tablets:

  • Wetting and cleaning surfactants – sodium lauryl sulfate.
  • Complexing agents – povidone.
  • Molasses starch, sucrose, lactose – as part of both tablets and capsules.

The approximate dosage of Irunin depends on the etiology of the disease:

  1. Pityriasis versicolor – 2 capsules one-time. The course is 1 week.
  2. Mycosis of smooth skin (epidermophytosis) – 1-2 capsules once. The course is 7-15 days.
  3. Fungal infection of the cornea – 1 capsule once a day. The course is 21 days.
  4. Vaginal candidiasis – 1 suppository 1-2 times a day. The course is 1-3 days.
  5. Oral candidiasis – 1 capsule for 15 days.

You can get rid of mycosis of the nail plates with the help of pulse therapy, or continuous treatment.

Onychomycosis of the hands – treatment is recommended in two courses of 7 days with a break of 3 weeks, drinking 2 capsules twice a day, or continuously for 3 months, two capsules per day.

Onychomycosis of the feet – in three courses with a break of 3 weeks , or continuously.

Deep mycoses – 1-2 capsules up to 2 times a day. The course can last up to six months and is determined by the degree of damage and the specificity of the disease.

High protein in urine during pregnancy

Fluconazole Description and dosage

The main component is fluconazole .

Additional:

  • Milk sugar.
  • Potato starch.
  • Emulsifier (magnesium stearate).
  • Enterosorbent (silicon dioxide).

The principle of operation of fluconazole is akin to itraconazole. They are also drugs of the same group – triazoles. Suppressing the synthesis of ergosterol, thereby fluconazole increases the permeability of the cell membrane of the fungus, depriving it of vital enzymes and components.

Fluconazole

The drug is effective in:

  1. Lesions of the skin and derivatives – onychomycosis, pityriasis versicolor and others.
  2. Coccidioidosis
  3. Sporotrichosis.
  4. Histoplasmosis.
  5. The defeat of various systems and organs by the causative agent of the genus Candida – genitourinary, digestive, respiratory. Fluconazole acts both with invasive infection (including candidaemia) and non-invasive and is used as a prophylaxis in the postoperative period.
  6. Diseases of a systemic nature, provoked by the genus Cryptococcus (meningitis, skin, pulmonary infections) both in the case of direct infection, and arising from the suppression of immunity.

The drug is available in the form of capsules of 50, 100 and 150 mg, injection and suspension – 5 mg / ml.

The approximate dosage for adults depends on the etiology of the disease and the severity of the course:

  • Cryptococcal meningitis – up to 0.4 g / day . In case of a life threat – up to 0.8 g / day.
  • Coccidioidosis – up to 0.4 g / day . The treatment period is up to 2 years.
  • Candidemia – 0.4 g / day (including a double dose on the first day). Treatment continues until the disappearance of all signs of the disease.
  • Candidiasis of the mucous membranes – up to 0.4 g per day for 7-30 days, which depends on the location of the infection.
  • Chronic candidiasis – up to 0.1 g per day for a month.
  • Vaginal candidiasis – 0.15 g once.
  • Fungus of the feet, groin, smooth skin – 50 mg / day or 150 mg / week for 2-6 weeks.
  • Onychomycosis – 0.15 g for 7 days until a new nail grows.

For children, the dosage of 3, 6 and 12 mg / day is comparable to 100, 200 and 400 mg / day for adults. The permissible age for the use of the drug is associated with the child’s ability to consciously swallow and occurs at about 5 years old.

What is common and how are they different?

Although the principle of action for the drugs Irunin and Fluconazole is the same, there are still a number of features that determine each of them its own consumer audience.

Irunin Fluconazole
Active substance Itraconazole Fluconazole
Features of distribution in the body Concentrated in liquid media within 3-4 hours after administration.

Mostly in the blood.

After 1.5 hours, it is completely distributed throughout the body.

It is distributed in all liquids equally.

Contraindications · Hypersensitivity.
· Concurrent administration of cisapride, terfenadine, astemizole, pimozide, quinidine, amiodarone, erythromycin.
· Children’s age up to 4 years.
· Hypersensitivity.
· Concomitant use with cisapride, terfenadine, astemizole, pimozide, quinidine, amiodarone, erythromycin.
· Children’s age up to 4 years.
· Pregnancy and lactation period.
average cost Pack of 6 capsules – 410 rubles.

10 capsules – 580-660 p.

14 capsules – 760-820 p.

Vaginal tablets – 400-490 p.

Packaging 1 capsule (150 mg) – 10-25 p.

2 cap. (150 mg) – 21/180 p. (Medisorb)

4 capsules (50 mg) of Vertex – 74 p.

4 cap. (150 mg) “Ozone” – 52 p.

On 7 capsules (50 mg) “Ozone” – 17 rubles.

Manufacturer Veropharm OJSC, Russia OZON LLC, Russia.

Vertex, Russia.

Promed

Among other things, fluconazole has an extremely low effect on liver cytochromes similar to fungicides. While Irunin is highly specific for two types of proteins, which is important to consider when treating patients prone to hepatic and renal diseases.

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