It is impossible to say which drug is better, since the drug can have a different effect on the patient’s body. A cardiologist should choose an antihypertensive medication taking into account the diagnosis, the presence of contraindications, the patient’s response to therapy. For the treatment of arterial hypertension, the medications Concor and Kapoten are prescribed. Before you start taking them, you need to figure out what is common between them and how they differ.
Concor
Concor is available in tablets in dosages of 5 mg and 10 mg. The therapeutic effect of them is explained by bisoprolol.
The tablets are convex on both sides, they are heart-shaped. 5 mg preparation is pale yellow, 10 mg pale orange. There is risk on both sides of the pill.
The composition of the medication includes the following additional ingredients:
- MCC.
- Maize starch.
- Aerosil.
- Crospovidone.
- E576.
- Calcium hydrogen phosphate anhydrous.
The film sheath is formed by the following components:
- Hypromellose.
- Propylene glycol.
- Dimethicone.
- Titanium white.
- Iron oxide is yellow.
Concor 10 mg in addition to these substances contains red iron oxide.
Bisoprolol is a selective β1-blocker. Against the background of taking the medication, the OPSS decreases, the heart’s need for oxygen decreases, the heart rate decreases, blood pressure drops.
The active substance is well adsorbed from the digestive tract, the bioavailability of the drug is 90%. The maximum concentration in the blood is noted 2-3 hours after ingestion. Up to 30% of the dose taken is associated with proteins. Passing through the liver, bisoprolol is metabolized. The medicine is removed in equal amounts with urine and bile. The elimination half-life varies from 10 to 12 hours, which allows you to take the medicine once a day.
Kapoten
Kapoten is available in pure white or creamy tint tablets, square in shape with rounded edges. The drug has a specific smell. The tablets are biconvex, on one side there is a cruciform notch. Slight marbling is allowed.
As the main component, the medication contains captopril. In addition to it, the composition of the tablets includes the following formative components:
- MCC.
- Maize starch.
- Milk sugar.
- Stearic acid.
Captopril is an ACE inhibitor. It blocks the biosynthesis of angiotensin II and removes its vasoconstrictive effect on arteries and veins. Against the background of taking the medication, the general peripheral vascular resistance decreases, pre- and afterload on the heart, blood pressure decreases.
After oral administration, the drug is rapidly adsorbed in the digestive tract. The absorption rate of the drug slows the simultaneous ingestion of food. The highest concentration of captopril in the blood is noted after an hour. The bioavailability of the drug varies from 60% to 70%. Up to 30% of the drunk dose binds to blood proteins. Captopril is excreted from the body mainly with urine, the half-life can vary from 2 to 3 hours.
What is common between drugs
Kapoten and Concor have the following similarities:
- Both drugs are contraindicated in persons under 18 years of age. They are incompatible with breastfeeding, so it is recommended that the infant be transferred to the mixture during therapy.
- Medications are used to treat high blood pressure and chronic heart failure.
- The shelf life of the drugs is 5 years.
- Both medicines can cause a strong decrease in blood pressure, allergies, bronchospasm, runny nose, itching, rash, hair loss, vertigo, headache, insomnia, depression, weakening potency, impotence, increased liver enzyme activity, nausea, vomiting, indigestion, delayed stool, hepatitis.
Comparison and differences
Hypertensive drugs have the following differences:
- Kapoten is forbidden to drink during the period of gestation. Concor women in position can be taken according to strict indications.
- Kapoten is prescribed for violation of the function of the left ventricle caused by myocardial infarction, as well as with diabetic nephropathy provoked by diabetes mellitus. Bisoprolol is used to treat stable angina pectoris.
- The hood should be stored at temperatures up to 25 degrees, Concor – up to 30 degrees.
- Kapoten can cause heart palpitations, heart rhythm disturbances, Raynaud’s syndrome, hot flashes, pallor, cardiac arrest, cardiogenic shock, dry cough, dyspnea, pulmonary edema, eosinophilic pneumonitis, drowsiness, sensory disturbance, ataxia, confusion, and circulatory disorders in the brain, impaired vision, changes in blood composition, autoimmune pathologies, increased titer of antinuclear antibodies, joint and muscle pain, enlargement of the mammary glands in men, edema, chest pain, fever , taste distortion, gastrointestinal mucosa irritation, abdominal pain, dry mouth, refusal to eat, stomatitis, glossitis, digestive tract ulcers, pancreatic inflammation, gum hyperplasia, liver and kidney pathologies, increase or decrease daily diuresis.
- Kapoten is contraindicated in patients with Quincke’s edema associated with treatment with ACE blockers, hereditary Quincke’s edema, severe liver and kidney pathologies, high levels of potassium in the blood, renal vascular stenosis, transplanted kidney, narrowing of the aortic orifice, diseases in which there is a violation of the outflow of blood from the left ventricle. It should not be drunk for diabetics and people with impaired renal function if they receive treatment with drugs based on aliskiren. Concor is prohibited in acute heart failure, decompensated heart failure, cardiogenic shock, sinus node weakness, severe AV block, severe bronchial asthma, bradycardia, arterial hypotension, sinoatrial blockade, Raynaud’s syndrome, severe peripheral circulation disorders, pheochromocytoma, metabolic a.
