Arthrosan and Diclofenac, the choice of drug

The doctor should decide what is best for Arthrosan or Diclofenac, depending on the diagnosis, the presence of contraindications, patient tolerance to therapy. Arthrosan injection is recommended when an acute stage of the disease is observed. They are made no more than 6 days, then, if necessary, they switch to oral forms.

Patients who can not give injections or take pills should opt for Diclofenac in suppositories, gel or ointment. Both drugs are prescription, so self-medication with them is unacceptable.

Arthrosan and Diclofenac belong to the group of non-steroidal anti-inflammatory drugs. These medicines are used to relieve pain and inflammation that accompany the pathology of the musculoskeletal system. Let’s compare which medication and when is better.


Arthrosan is sold in ampoules and tablets. As the main component, the medication contains meloxicam, which eliminates pain and inflammation, normalizes body temperature during fever. It refers to derivatives of enolic acid. The drug suppresses the COX-2 enzyme involved in prostaglandin biosynthesis. It is these substances that support the inflammatory process in the body.


Meloxicam has virtually no effect on COX-1, so it rarely causes unwanted reactions from the digestive tract.

The drug only removes signs of the disease, such as pain and inflammation, while it does not inhibit the progression of the pathology.

After oral administration, Arthrosan is well absorbed from the digestive tract. Its bioavailability in tablets is 90%, when introduced into the muscle, it reaches 100%. Only 1% of the dosage taken does not bind to proteins. The active substance penetrates through internal barriers, its content in the blood is 2 times greater than in synovia. In the liver, it is metabolized. A medication with urine and bile in the same proportions is excreted. The elimination half-life can vary from 13 to 25 hours.

The drug is prescribed for symptomatic treatment of the following pathologies of the locomotor system:

  • Osteoarthrosis.
  • Ankylosing spondylitis.
  • Rheumatoid arthritis.
  • Sciatica, radiculopathy and other inflammatory and degenerative pathologies of the musculoskeletal system, which are accompanied by pain.

Diclofenac is produced by a number of Russian and foreign companies. On sale, it is in tablets, ampoules, eye drops, rectal suppositories, gels and ointments.


Diclofenac is a phenylacetic acid derivative. It stops the inflammatory process and pain, has a moderate antipyretic effect. Diclofenac blocks the activity of cyclooxygenase. This enzyme is involved in the metabolism of arachidonic acid, from which prostaglandins are formed, which are involved in the pathogenesis of pain, inflammation and fever.

The analgesic effect is associated with 2 mechanisms:

  1. Peripheral (indirectly, through blocking the biosynthesis of prostaglandins).
  2. Central (due to the suppression of the formation of mediators of pain and inflammation in the peripheral and central nervous system).

With rheumatic diseases, diclofenac weakens pain in the joints at rest and during movement, reduces the stiffness and swelling in them, which is observed in the morning. During therapy, joint mobility increases.

Relieves pain after trauma and surgery, reduces inflammatory edema, suppresses platelet adhesion, with prolonged use it exhibits a desensitizing effect.

After oral administration, diclofenac is absorbed by the gastrointestinal tract, food intake will not alter the degree of absorption, but it slows it down. When introduced into the anus, the rate of absorption is slightly less than after oral administration.

In the liver, diclofenac is metabolized. The highest concentration in the blood after oral administration is achieved after 2-4 hours, after administration into the rectum – after 1 hour, after intramuscular administration – after 20 minutes. Communication with plasma proteins is almost 100%. In the body, diclofenac does not cumulate. The drug penetrates the blue. Here, the highest concentration is reached 2-4 hours later than in the blood. Up to 60% of the dosage is excreted in urine, the rest with bile. The half-life of blood varies from 1 to 2 hours, from the synovia from 3 to 6 hours.

Tablets, injections, suppositories, ointment and gel are used to relieve pain and inflammation, which are observed against the background of pathologies of the musculoskeletal system:

  • Myalgia.
  • Radiculopathy.
  • Sciatica.
  • Rheumatoid arthritis.
  • Osteoarthrosis.
  • Lumbago.
  • Pain that is observed after injuries, bruises and sprains.
  • Tunnel Syndrome.
  • Inflammation near the joint bag.
  • Tenovaginitis.
  • Periarthritis.

Eye drops are used to suppress myosis and prevent cystic edema of the macula in the surgical treatment of cataracts. They are used to treat conjunctivitis of non-infectious genesis.

They are used for the treatment and prevention of inflammation after surgery on the eyeball, after an injury.

What is common between means

Both drugs belong to the NSAID group. Arthrosan and Diclofenac have an analgesic, antipyretic and anti-inflammatory effect.

Medicines can not be used if the following pathologies are observed:

  1. Intolerance to the composition of the drug and other non-steroidal anti-inflammatory drugs.
  2. Peptic ulcer, bleeding from the digestive tract, cerebral hemorrhage.
  3. Severe impaired liver, kidney and heart function.
  4. Condition after coronary bypass surgery.
  5. Relapse of ulcerative and granulomatous colitis.
Comparison and differences

Between non-steroidal anti-inflammatory drugs there are the following differences:

Arthrosan Diclofenac
Manufacturing company Pharmstandard, Russia. Groteks Ltd., A.D. Hemofarm and others.
Contraindications You can not do injections if the patient receives anticoagulants, as there is a risk of hematomas. Clotting disorder and other blood pathologies.
Use during pregnancy and breastfeeding. Arthrosan is not allowed for women in the position and supporting breastfeeding. Diclofenac in the I and II trimester of pregnancy should be used with caution. In the last trimester and during breastfeeding, it is contraindicated.
Application in children’s practice Injections are allowed only for adults, tablets can be from 15 years. In a suitable dosage form, diclofenac can be from 6 years old.
Dosage Forms Pills, injections. Gel, ointment, tablets, injections, suppositories, eye drops.
Price The price of the drug depends on the dosage form and the number of injections or tablets in the package. The cost of the medicine is 150-500 rubles. The cost of the drug may vary significantly depending on the manufacturer. The price of a medicine starts from 30 rubles.

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