29.03.2024

Metipred and prednisolone, the choice of drug

You should not choose between these two drugs, because they have a similar mechanism of action. The doctor selects the drug individually, based on the clinic of the disease, severity and body reaction to the drug.

The only thing a patient can pay attention to when choosing a particular medicine is the price.

Three Prednisolone ampoules cost 35 rubles., Tablets – 100 rubles., Metipred is more expensive. Tablets cost about 200 rubles, and a 250 ml bottle – 320 rubles.

Sometimes a person can get sick with autoimmune diseases, in which infected immune cells begin to attack themselves. There are moments at which a person can fall into a critical state.

In such cases, the introduction of drugs that suppress the immune system is necessary . The best among them are Metipred and Prednisone. It is impossible to cure autoimmune diseases, but it is possible to extinguish the focus of inflammation for a while. This is what these drugs do.

“Metipred”: description, method of use and contraindications

Metipred has anti-inflammatory as well as immunosuppressive effects. Contains methylprednisolone. It is available in the form of tablets or a lyophilisate for the preparation of a solution for intravenous, intramuscular administration.

Metipred

When taking the drug, the concentration of globulin in the blood decreases, the synthesis of higher fatty acids, triglycerides increases. As for the gastrointestinal tract, glucose transport from the liver to the blood is accelerated here. Also, methylprednisolone increases the absorption of carbohydrate, retains water, sodium in the body.

Indications for use:

  1. Autoimmune diseases.
  2. Rheumatoid diseases.
  3. Allergic reactions.
  4. Bronchial asthma.
  5. Hepatitis of various origins.
  6. Tuberculosis.
  7. Various skin diseases.
  8. Kidney disease and adrenal insufficiency.
  9. Cerebral edema.
  10. Multiple sclerosis.
  11. Blood disease.
  12. Myeloma

It has no contraindications, cases of overdose. It has side effects:

  • Steroid diabetes.
  • Nausea, vomiting.
  • Arrhythmia, bradycardia.
  • Disorientation, hallucinations.
  • Osteoporosis.
  • Itching, rash.
  • Anaphylactic shock.

The method of application and dose is calculated by the doctor, based on the clinic, the severity of the disease.

Tablets should be taken at intervals of 6-8 hours. The initial dose is 4 mg. The dose increases if the severity of the disease increases. With multiple sclerosis and cerebral edema, the daily dose can reach 200 mg.

For children, the dose is calculated taking into account the weight. Do not sharply drop the course of taking Metipred. The dose should be reduced gradually, minimizing.

The solution for intramuscular and intravenous administration is used at the time of life-threatening conditions of 30 mg for 48 hours.

In the treatment of multiple sclerosis, lupus erythematosus, rheumatic diseases, edematous conditions, 1 g of methylprednisolone is administered intravenously for 3 to 5 days.

With cancer, 125 mg per day is administered to improve life for 2 months. With side effects of chemotherapy, 250 mg is administered intravenously an hour before or after the administration of a chemotherapeutic drug.

For other diagnoses, 10 to 500 mg per day is administered , depending on the severity of the disease. Small doses are administered to children, but not less than 1 mg per day, given the condition of the child and his reaction to the drug.

Metipred is dispensed from pharmacies only by prescription, is stored at a temperature not exceeding 25 degrees. Shelf life 5 years.

“Prednisolone”: description, method of use and contraindications

Prednisolone has an anti-inflammatory, immunosuppressive effect. It is also used against allergic diseases of various origins.

The main substance in the composition of the drug is prednisone. Available in the form of ampoules, a solution for intravenous and intramuscular administration.

Prednisolone

When using the drug, the synthesis of albulin in the liver and kidneys increases. The concentration of globulin in the blood decreases, the synthesis of higher fatty acids, triglycerides increases.

Indications for use:

  1. Bronchial asthma.
  2. Rheumatoid diseases.
  3. Inflammatory diseases of the joints.
  4. Cerebral edema.
  5. Various skin diseases.
  6. Adrenal insufficiency.
  7. Nephrotic syndrome.
  8. Autoimmune diseases.
  9. Multiple sclerosis.
  10. Hepatitis of various origins.
  11. Tuberculosis.
  12. Lung disease.
  13. Shock states.

It has no contraindications and overdose, however, it has a number of side effects:

  • Disorientation, hallucinations.
  • Itching, rash.
  • Nausea, vomiting.
  • Anaphylactic shock.
  • Arrhythmia, bradycardia.
  • Steroid diabetes.
  • Osteoporosis.

Dosage and administration are calculated individually by the doctor, based on the clinic and the severity of the disease.

In cases of acute adrenal insufficiency, as well as manifestations of allergic reactions, 100-200 mg is administered for 3-7 days.

In bronchial asthma, the daily dose ranges from 70 mg to 700 mg, depending on the severity, can reach 1400 mg per day.

With rheumatoid arthritis, lupus erythematosus, acute hepatitis, poisoning by cauterizing fluids and burns, the daily dose is from 75 mg to 400 mg. If indicated, the dose may increase.

In an asthmatic attack, 500-1200 mg of prednisolone is used, with a thyrotoxic crisis – 200-300 mg per day. If necessary, increase the dose to 1500 mg.

Do not abruptly drop the course of taking Prednisone. The dose should be reduced gradually, minimizing.

Prednisone is dispensed from pharmacies only by prescription, stored at a temperature not exceeding 25 degrees. Shelf life 5 years.

What are the similarities between Metipred and Prednisolone?

Both drugs contain prednisone. Used for the relief of acute attacks of diseases and maintaining a stable patient.

Metipred and Prednisolone are anti-inflammatory drugs that have an immunosuppressive effect.

What are the differences between Metipred and Prednisone?

Metipred has greater glucocorticoid activity than prednisolone. Less commonly, it causes negative reactions, such as a decrease in appetite, changes in the psyche.

Prednisolone retains water in the body more than Metipred, which leads to weight gain.

However, taking into account patient reviews, Prednisolone was more effective in treatment, remission after it arose faster and lasted longer than after Metipred.

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