21.10.2020

Piroxicam and Meloxicam, the choice of drug

It is impossible to say unequivocally about which drug is better. Treatment should be under the supervision of a doctor , with an appointment for a specific patient. Based on his analyzes, and the general condition of the body, concomitant diseases. But drawing a conclusion from the above, we can say that Meloxicam is less harmful to the body than Piroxicam. Meloxicam, unlike Piroxicam, does not interact with other drugs, which allows patients with concomitant diseases to take it, and this is an important factor in treatment.

Rheumatoid arthritis is one of the most common joint diseases today. Every hundredth inhabitant of the planet knows what joint inflammation is. This is especially true for women. They are 6 times more likely to be affected by this disease. Due to the general effort of the body, slowing down metabolic processes, the development and assimilation of various substances, such problems arise. This is due to heredity, lifestyle, human activities, so from the age of 30, there is a risk of this disease.

Rheumatoid arthritis is an autoimmune disease (a disease of the immune system when one’s own tissues are perceived as foreign), affecting the connective tissue, as well as small joints. It manifests itself mainly in the form of inflammation. The synovial membrane, articular cartilage, joint capsule suffer. Inflammation leads to erosion and subsequent deformities. Loose granulation tissue is formed and grows, which gradually destroys the cartilage, other organs and systems also suffer.

The reason for the development of rheumatoid arthritis has not yet been elucidated.

Mostly suspected:

  1. Viral infections.
  2. Infectious factors.
  3. Genetic factor.
  4. Decreased immunity.
  5. Severe stress.

It is impossible to completely cure arthritis . But to maintain the initial state, to prevent development, and it is easier to tolerate the disease, is quite real. So, to relieve pain and inflammation, Piroxicam and Meloxicam are used.

Piroxicam

Pyroxicam, referred to as NSAIDs ( oxycams ), which have anti-inflammatory, analgesic, antiplatelet, antipyretic effects. It suppresses COX-1 and COX-2. Anesthesia occurs within 30 minutes after administration. It is used to treat dysmenorrhea, gout. Anti-inflammatory effect, achieved after a week or even a two-week course. The pharmacological effect in the body persists throughout the day.

Piroxicam

They are available in the form of capsules, a solution for intramuscular administration, rectal suppositories, tablets, coated tablets, and cream, gel (this form helps to achieve a therapeutic effect with minimal exposure to blood plasma).

Contraindications:

  • Individual intolerance.
  • Ulcer, gastrointestinal tract lesions.
  • Hepatic, renal failure.
  • Bleeding.
  • It is forbidden to admit to persons under the age of 18 years.
  • Pregnancy.
  • Lactation period.
  • Forbidden to persons over 65 years of age.
  • It should be limited to driving a car and working with mechanisms.

Also, during treatment , ethanol is prohibited . Concomitant use with contraceptives reduces their effect. For external use, gel or ointment should not be applied to damaged areas. Also, do not combine with other NSAIDs, acetylsalicylic acid, diuretics (increased nephrotoxicity), antihypertensive drugs. During treatment with piroxicam, simultaneous administration of gastroprotectors or proton pump inhibitors (omez) is recommended.

The filtration process in the kidneys

Meloxicam

Meloxicam – NSAIDs from the enolic acid class . It has anti-inflammatory, analgesic, antipyretic (antipyretic) effects. It prevents the biosynthesis of prostaglandins (responsible in the body for the appearance of pain and swelling at the site of inflammation), while inhibiting the activity of COX-2. Injectable dosage form is used for short-term treatment of an attack of rheumatoid arthritis, treatment of ankylosing spondylitis, arthrosis, polyarthritis.

Meloxicam

The concentration of the substance is achieved within 3-5 days and lasts for 20 hours . To reduce the risk of diseases of the gastrointestinal tract, simultaneous administration with gastroprotectors or with proton pump inhibitors (Omez) is also recommended.

Meloxicam is released in injection and tablets.

Contraindications:

  • Intolerance to the components.
  • Bronchial asthma.
  • Pregnancy.
  • Children under 16 years old.
  • Gastric bleeding, ulcers.
  • Hepatic and renal failure.
Similarities and differences

During a medical study conducted in the UK, it was found that the effectiveness of Piroxicam and Meloxicam is the same , but tolerance, from the digestive tract, is better with Meloxicam. Adverse reactions from the gastrointestinal tract were more often observed in patients who used Piroxicam.

Comparative experiments on the tolerance of intramuscular injection (CFC), which is characterized by local tissue damage at the injection site, were also conducted. The results showed that in patients taking piroxicam, the level of creatine phosphokinase increased, while in people receiving meloxicam, the level of creatine phosphokinase remained unchanged. That is, with intramuscular injection of Meloxicam, less local hyperemia is noted.

It is also often prescribed in combination with muscle relaxants, which greatly enhances the effect. Also, the positive effect of meloxicam on patients with coronary heart disease has been proven. Its combined use with acetylsalicylic acid reduced the number of cardiovascular complications.
Side effects

When observing the following effects, it is necessary to stop taking the drugs and consult a doctor.

  • Dizziness.
  • Trouble sleeping.
  • Swelling.
  • Itching
  • Vision problems.
  • Rash.
  • Spasm of the bronchi.
  • Gastrointestinal Disorders.
  • Decrease in the content of leukocytes, platelets, hemoglobin.

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