31.10.2020

Urdox and Ursofalk, drug choice

Urdoxa and Ursofalk are completely interchangeable and after consultation with a specialist you can drink any of these drugs.

When prescribing treatment for children, it is better to give preference to suspensions, since not every child can swallow a tablet or capsule.

Both medicines are dispensed upon presentation of a prescription from a doctor, therefore self-medication is contraindicated by them, only a specialist can correctly assess the severity of the clinical picture and calculate the dosage, depending on the diagnosis and body weight of the patient.

For the dissolution of stones in the gall bladder, Urdox and Ursofalk are used. These drugs belong to hepatoprotectors and are complete analogues. Let’s see what are the differences between the drugs.

Urdox

Urdox is available in capsules, which contain ursodeoxycholic acid as the main substance .

Urdox

In addition to her, the composition of the drug includes such indifferent ingredients as:

  • Maize starch.
  • Aerosil.
  • E576.
  • Gelatin.
  • Titanium white.

The drug is available in white opaque capsules, inside them contains white or almost white powdery or granular substance.

The drug has a choleretic effect , helps dissolve stones, lowers cholesterol and fats in the bloodstream, and boosts immunity. The active substance is embedded in the cell membrane of the liver and protects it from damage by salts of cholic acids.

In case of stagnation of bile, it activates the Ca 2+ -dependent α-protease and the process of exocytosis, reduces the content of harmful bile acids, the level of which is increased in patients with liver pathologies. During treatment with the drug, the absorption of lipophilic bile acids in the digestive tract decreases, bile formation increases, the movement of bile improves, and the excretion of harmful bile acids with feces is accelerated.

The drug reduces the biosynthesis and secretion of cholesterol in the liver , blocks its absorption in the intestine, increases its solubility, all of which lead to a decrease in the saturation of bile with cholesterol.

Against the background of taking the drug, the ability of bile to form stones decreases , its composition changes, it becomes more bile acids, the secretion of gastric juice and digestive enzymes increases, lipase activity increases, blood sugar level decreases.

The active substance can partially or completely dissolve cholesterol gallstones.

After oral administration, up to 90% of the dose taken is absorbed in the small intestine, and the remainder in the ileum. The highest concentration is achieved after 1-3 hours . Up to 99% of the accepted dosage combines with plasma proteins. The drug penetrates the placenta, is metabolized in the liver. From 50 to 70% is excreted in feces. The elimination half-life can vary from 3.5 days to 5.8 days .

Anatomy and function of the human kidney

Ursofalk

Ursofalk is available in tablets, capsules and suspensions. The active substance of the drug is ursodeoxycholic acid .

Ursofalk

The composition of the tablets includes the following formative components:

  • MCC.
  • Povidone-K 25.
  • E553b.
  • E576.
  • Aerosil.
  • Twin 80.
  • Propylene glycol.
  • Hypromellose.

The tablets are white in color, on both sides they have a risk. They are oblong, biconvex in shape.

The composition of the suspension includes the following additional substances:

  1. Perfume lemon.
  2. E330.
  3. Sodium chloride, citrate, cyclamate.
  4. Macrogol.
  5. MCC.
  6. Glycerol.
  7. Xylitol.
  8. Water.
  9. E210.

In appearance, the suspension is a homogeneous white liquid in which small air bubbles can be seen. She smells like lemon.

The composition of the capsules includes the following indifferent components:

  • Aerosil.
  • Maize starch.
  • E576.
  • Titanium white.
  • Gelatin.
  • Water.
  • E487.

The capsules are white in color, white powder or granules are inside. Urdoxa and Ursofalk have an identical mechanism of action, they have similar effects.

Ursofalk, regardless of the form of release, protects the liver cells from destruction, promotes the regeneration of its tissues. The medication has a choleretic effect. It promotes the lysis of cholesterol stones, in time it usually takes from six months to 2 years . But if after a year of therapy the stones do not decrease in size, then it must be interrupted.

While taking the medication, you need to evaluate the effectiveness of the treatment using ultrasound or radiography. It is necessary to monitor whether calcification of stones is observed; if this happens, the therapy is canceled.

Similarities of funds

Medicines are prescribed to dissolve cholesterol stones in the gall bladder. In addition, they are prescribed in the presence of the following pathologies:

  • Chronic inflammation of the liver of various origins.
  • Bile duct dysfunction.
  • Damage to the liver by alcohol-containing drinks.
  • Compensated primary biliary cirrhosis.
  • Gall reflux gastritis.
  • Cystic fibrosis.
  • Primary sclerosing angiocholitis.
  • Fatty degeneration of the liver.

Medicines should not be drunk in the presence of the following pathologies:

  1. Gallstones that contain many Ca ions.
  2. Acute cholecystitis and colitis.
  3. Non-functioning gall bladder.
  4. The acute period of cholangitis.
  5. Decompensated cirrhosis of the liver.
  6. Severe pathologies of the kidneys, liver and pancreas.
  7. Allergy to the composition of the drug.
  8. Lactation period.

You can drink medicines during the period of gestation when the benefit to the mother exceeds the harm to the child.

Against the background of treatment with both drugs, a number of adverse reactions can occur:

  • Diarrhea, nausea, vomiting, pain in the right upper quadrant.
  • Increased activity of liver enzymes.
  • Calcination of bile calculi.
  • Uncompensated cirrhosis of the liver, which occurs after discontinuation of therapy.
  • Uurtikaria.

To date, there have been no cases of overdose with Urdox and Ursofalk.

Medicines do not adversely affect the ability to drive a car.

Comparison and differences

Urdoxa and Ursofalk have the following differences:

Urdox Ursofalk
Dosage Forms Capsules Suspension, capsules, tablets.
Producing country Russia. Germany.
Application in children’s practice Allowed from 3 years. Suspension is allowed from birth.
Shelf life 4 years. Capsules are suitable for 5 years, tablets and suspension for 4 years, but the last one after opening the package can be used for 4 months.
Price The cost of 50 capsules is about 750 rubles. The price of the drug depends on the form of release, dosage, the number of capsules and tablets in the package. The cost of 50 capsules is more than 900 rubles.

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