Amlodipine-Prana – drug class antihypertensive and antianginal means. If the doctor prescribed you the medication before taking it is familiar with its operation, as well as features.


The main component of the drug Amlodipine-Prana is amlodipine. Amlodipine was originally marketed by Pfizer as a drug called Norvasc. Currently, many companies in Russia, Eastern Europe and India produce their own medicines containing amlodipine. In addition, amlodipine is included in the list of essential medicines of the who.

Chemists refer to amlodipine, dihydropyridine derivatives, and pharmacologists – a selective blocker of slow calcium channels. The drug is representative of the 2nd generation of this type of funds.

Advantages of drugs of the 2nd generation compared to 1st generation tools, are:

  • the increased duration of action,
  • the high level of tissue specificity,
  • fewer side effects.

Most effective amlodipine in ischemic heart disease, with which he has anti-sclerotic and cardioprotective action.

How else could the amlodipine implements these functions? The compound blocks the flow of calcium ions into certain cells, primarily in muscle cells covering the blood vessel walls. The lack of calcium in these cells causes an expansion of the lumen of blood vessels. Basically the drug acts on the muscle cells responsible for contraction of blood vessels, not in heart muscle cells. However, the drug has not only vasodilator, but also anti-anginal effect, that is, it reduces the need heart of oxygen. This effect occurs due to the expansion of arterioles and large coronary arteries. Vazodilatiruushimi effect of the drug also leads to a decrease in blood pressure.

For drug is not is characterized by the occurrence of reflex tachycardia type. In patients with stable angina drug that promotes physical activity easier for them migrate. It is important that angina the drug reduces the frequency of attacks. The drug does not reduce left ventricular ejection of the heart and thus helps reducing the degree of left ventricular hypertrophy. Amlodipine does not affect the conductivity of the cardiac muscle, metabolic processes in the body, metabolism of fats and glucose in the blood. It can be used by diabetic patients suffering from bronchial asthma and gout. In addition, the drug has a slight diuretic effect.


Most often the drug is administered to people who have problems with the cardiovascular system. First and foremost is coronary heart disease in the stage of compensation, of Prinzmetal angina (spastic angina), exertional angina, stable angina.
The second main category of people who have shown the drug, that people suffering from arterial hypertension. Typically, receiving funds, reducing blood pressure, is recommended in stable pressures exceeding 140/90. However, in some cases, medication may be prescribed and people with lower pressure.

Hypotensive effect begins to manifest itself after 2-4 hours after administration and a significant reduction in blood pressure occurs in about 6-10 hours and lasts about a day. The stationary concentration of active substance in the blood observed after 7-8 days after the start of. Thus, the drug is not very effective hypertensive crises. This tool is not for emergency care, but rather for long-term symptomatic treatment of hypertension.

It should be noted that, despite the fact that the drug has some contraindications, to take remedy for hypertension or ischemia should not be. Only the specialist can choose the most effective drug in each case.

Release form

Option called amlodipine Amlodipine-Prana produced Samara pharmaceutical company “Prana-farm”. In addition, amlodipine is manufactured and other pharmaceutical companies, both domestic and foreign, so in the absence of the drug in pharmacies it is easy to replace.

Tablets Amlodipine-Prana have a dose of 5 mg and 10 mg. Although some other manufacturers there are tablets 2.5 mg.

In addition to amlodipine in the composition of the tablets also include potato starch, calcium stearate, hydroxypropylmethyl cellulose, and lactose monohydrate.

Tablets can be purchased at the pharmacy on the prescription of your doctor.

Amlodipine can be produced also in combination with other antihypertensive compounds – valsartan, bisoprolol, perindopril, lisinopril.

Other forms of the drug, for example, in the form of a solution for parenteral administration, does not exist.


Most doctors and patients speak positively about the drug, although some doctors consider it to be somewhat outdated and not sufficiently effective. Also, many noted the high availability of the drug, its low price. However, some patients complain of a large number of side effects, in particular swelling in the legs.


The drug is allowed to not accept all patients. First of all, it is the patients with very low systolic (upper) blood pressure less than 90 mm Hg. the article Also forbidden to give the drug to patients who have not reached the age of majority. The fact that the safety of the drug in children has not been thoroughly investigated. Not permitted drug and stenosis of the aorta, a state of collapse, dysfunction of the mitral valve, acute myocardial infarction, unstable angina, cardiogenic shock.

With caution the drug is prescribed for disorders of the liver, syndrome weakness sinusnogo hub, chronic heart failure of nonischemic etiology, moderate hypotension in the elderly.

Also note that the product contains lactose, which can cause hypersensitive reactions in predisposed people.

The use of Amlodipine in pregnancy and lactation

The tool is sometimes prescribed for pregnancy, however, if it is dictated by concern for the life and health of the mother and the risk to the fetus is negligible. Thus, the question of the use of the drug in such a situation, is administered by the attending physician. Still it should be noted that the drug could have negative effect on the fetus. If the woman is breastfeeding, in this situation the drug is not permitted because it passes into breast milk.

Side effects

The most common side effects (more than 1 in 100 patients) – swelling of peripheral tissues and extremities, rush of blood to the face, palpitations, drowsiness, fatigue, nausea, abdominal pain, headache and dizziness. Other negative symptoms are much less common. More than 1 cases out of 1,000 there are:

  • excessive decrease in blood pressure;
  • General malaise;
  • asthenia;
  • insomnia;
  • anxiety;
  • depression;
  • vomiting;
  • constipation;
  • diarrhea;
  • flatulence;
  • thirst;
  • dry mouth;
  • frequent urination;
  • rhinitis;
  • shortness of breath;
  • pain in muscles, joints or back;
  • disorders of vision and hearing.

As is quite common side effects of the drug, especially at the beginning of therapy, are dizziness and drowsiness, this fact should be considered by people managing vehicles, or performing work requiring concentration.

Instructions for use Amlodipine

As a rule, patients are assigned not more than one pill a day. This is due to the fact that the active substance is able to the body for a long time. But the dosage can vary from 2.5 to 10 mg. It depends on the severity of the disease and whether the drug as a maintenance agent or for the treatment of the active phase of the disease.

In the treatment of hypertension the usual dosage is 5 mg per day. The maximum dose that can be taken per day in this case was 10 mg. maintenance dose in this disease is usually 2.5 mg. In that case, if the patient the drug was prescribed anti-angina, the daily dose is also 5 mg per day.

How long should I take Amlodipine?

Amlodipine is a drug not for single reception. In most cases they require long-term therapy. Usually the duration of the course of treatment prescribed by the doctor. Typically, the tool will take in a few months with heart disease. The results of therapy is usually assessed through stress tests, results of laboratory tests and diagnostic procedures. And in hypertensive drug may be years or even for life. It all depends on how well the patient tolerates this tool.

The dosage of the drug in special patient groups

Patients suffering from renal insufficiency, the bolus is not required. Patients with human liver the drug is prescribed with caution. The initial dose for hypertension in such cases is 2.5 mg per day. If the drug is used as anti-anginal agents, although it is 5 mg a day. Older people dose adjustment is not required, but they need more careful observation of the doctor.

Do not require dose modification in patients receiving thiazide diuretics, ACE inhibitors and drugs that block beta-adrenergic receptors.

Other directions

Efficacy and speed of action depends on the meal. Thus, the drug can be taken before meals, during meals or after it. The pill should not be chewed or crushed. However, if your doctor has prescribed a dose of 2.5 mg, tablet 5 mg can be split in half. Swallow amlodipine tablets with a small amount of water.

Also there is not much difference in what time of day to take medication in the morning or evening. However, it is desirable to do it every day at about the same time. For a drug not characteristic of the syndrome, but the therapy is still recommended with a gradual reduction of the dose, for 5-7 days. During prolonged therapy should regularly check the blood pressure.

Interactions with other substances and drugs

A nonsteroidal anti-inflammatory drugs, especially indomethacin, alpha-agonists, anaesthetics, sympathomimetics, estrogens, calcium preparations, can reduce the effectiveness of amlodipine. Concomitant use of these drugs may cause the development of hypertensive crises.

This effect occurs because of fluid retention in the body. On the other hand, diuretics, nitrates, antihypertensives (other medicines belonging to the group of calcium channel blockers, ACE inhibitors and beta-blockers), drugs that have antianginal effects (riboxinum, nitroglycerin), quinidine, increase its hypotensive and antianginal efficacy.

Alpha blockers and antipsychotics only increase anti-hypertensive effect means.

Amlodipine may increase the neurotoxicity of lithium products. Neurotoxic effects can include ringing in the ears, trembling of extremities, loss of coordination, nausea and vomiting.

The product is compatible with cardiac glycosides. A single alcohol ingestion does not affect therapeutic effect of the drug. However, we are talking about single dose. Long-term use of alcohol may counteract the effect of the drug. Does not affect the action of the drug a single dose of sildenafil (Viagra).

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