Excedrin belongs to the analgesics-antipyretics, and has the combined properties. Pharmacological release type pills, which are coated with a film of white color, and the engraving is in the form of the letter “E” on one side. If the tablet is cut across, it can be seen in the middle, it will have a whitish-gray or yellow-whitish color. Each dose contains 0.25 g of paracetamol 0,25 g acetylsalicylic acid and 65 mg of caffeine. As additional components pharmacologists used 5 mg hyprolose, 0,10 g of microcrystalline cellulose and 2.5 mg of stearic acid. The film consists of Carnauba wax and a special film material.
The drug comes to the pharmacy market in several forms: in packages of a multilayer packaging in blisters and bottles.
Than justified the beneficial effects of the drug
- Paracetamol acts on the human body as an analgesic, antipyretic and anti-inflammatory. Affects thermoregulatory hearth, located in hypothalamuses area. Weakly inhibits the process of the synthesis of prostaglandins that occur in tissues of the periphery;
- Aspirin is intended for pain relief, fever relief and provide anti-inflammatory effects. She needs to stop feeling the pain caused by current inflammation, and reduce platelet aggregation, which reduces the rate of formation of blood clots. Microcotton increases in inflammatory foci;
- Caffeine needed to increase excitability in the spinal departments, and initiation of breathing, and a vasodilator center, toning blood vessels, direct blood flow in skeletal muscles, the brain, lowering platelet aggregation. It removes the feeling of lethargy, affects the level of functionality, mental and physiological strain. In the complex described medications this substance is contained in a small dosage, therefore, can not fully stimulate the Central nervous system, but it normalizes the vascular tone in the brain and accelerates the intensity of the flow.
Paracetamol is very easily digested from the stomach and intestines, its maximum content in plasma was observed after two hours. Metabolism of acetaminophen have on the liver, and the residual substances are excreted from the body through the kidneys. Forms a tenuous connection with the squirrels, if in the process of reception do not exceed the recommended dose.
Acetylsalicylic acid the body without the rest sucks very soon, with the same speed she gidrolizuyutza in the liver, then blood salicylates are formed and further metabolised in the liver.
Caffeine is absorbed quickly, particularly if the pill was on an empty stomach. The maximum concentration in plasma is reached in half an hour. Fully excreted by the kidneys, but before it penetrates into every fluid of the body.
How to use medicine for migraines
Tablets administered orally, it is best to do it after a meal or during it. Adults and adolescents the recommended one pill within seven hours. If the migraine is severe then in the first appointment you can drink at the same time two tablets. Standard dose per one day is four pills, maximum rate of five tablets.
After the first dose, the headache is often relieved very soon, after just ten minutes, in cases of chronic or complicated pain – in thirty minutes. If the pain does not let up for more than five days, you must seek the advice of a specialist. Chronic migraine cannot be treated with exedrin more than three days in a row.
The possible effects of exceeding the recommended dose
Signs of excess paracetamol is expressed in paleness of the skin, nausea, vomiting, anorexia, abdominal pain, improper assimilation of glucose, metabolic acidosis. Pathology of the liver functionality be seen within days after excess dose. If the overdose is severe, it can lead to hepatic failure and progressive encephalopathy, coma and death. As well as the development of acute renal failure complicated by tubular akrotiriani tissue, arrhythmias and pancreatitis. The effect of poisoning in an adult appears after it is adopted at least 10 grams of paracetamol.
- Poisoning mild signs of nausea, vomiting, tinnitus, visual disorders, dizziness, severe headache;
- Effects severe – is characterized by hyperventilation of the lungs, shortness of breath, cyanosis, excessive sweating, paralysis of the respiratory system, the respiratory acidosis.
Toxic poisoning is in the use of 150 mg. of substance per kilogram of patient weight. The greatest risk of overdose occurs in children and the elderly, when for several days they had adopted a dose of 100 mg per kilogram per day. Severe degree of intoxication requires immediate hospitalization.
In order to be poisoned by caffeine, you need to take it in a dose greater than 300 mg in one day. During this intoxication the patient is suffering from gastralgia, agitation, increased anxiety, excitement, motor disturbances, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, constant urination, headaches, increased sensitivity to pain and touch, tremors and muscle spasms. In addition, there may be signs of nausea, vomiting, ringing in the ears. Strong excess weight threatens tonic-clonic epileptic seizures.
When an excess of the major components of the drugs – need to monitor the electrolyte balance. In addition to the victim clear the stomach, cause vomiting, making the sorbent charcoal, laxatives and drugs are injected neutralizing the toxic effect. To avoid this, you should carefully read the description that’s given in the instructions to the drug and strictly follow the recommendations of its reception.
Drug interaction with other drugs
Excedrin interacts with heparin and indirect coagulants, reserpine, steroid hormones and enhances them. When administered simultaneously with other drugs of non-steroidal type anti-inflammatory effect, increases the chance of occurrence of different adverse effects.
- Drugs antihypertensive therapy;
- Drugs against gout;
- Funds for the accelerated excretion of uric acid.
In combination with barbiturates, rifampicin, salicylamide, antiepileptic sredstvami other microsomal enzymes of the liver form toxic metabolites which inhibit liver function. The absorption of paracetamol is accelerated while receiving metoclopramide.
Paracetamol delays excretion of chloramphenicol more than three times. Followed by a reception enhances anticoagulatory action, especially in cases where the anticoagulant is created on kumarinovy basis.
One-time reception of Excedrin and alcohol can increase the risk of hepatotoxicity. And the caffeine boosts the rate of absorption of ergotamine.
During pregnancy and breast-feeding ingestion of aspirin should be avoided as the safety of Excedrin for this population has not been studied enough. Doctors are increasingly talking about the fact that the drug is prohibited to appoint to future mothers and breastfeeding.
What kind of side effects can be
Side effects can manifest gastralgia, hepato and nephrotoxicity, erosions and ulcers in the intestine, allergic skin reactions, tachycardia, increase in blood pressure, bronchospasm. The constant use of the drug is fraught with dizziness, headache, eye disorders, tinnitus, decreased platelet aggregation, hypercoagulability, hemorrhagic syndrome, nasal and deshovye bleeding. And papillary nekrasivaya kidneys, deafness, syndromes Laella, Reye.
The children-preschoolers side effects have the form giperpirexii, acidosis on metabolic type disorders of the functionality of the Central nervous system and mental state, vomiting, loss of liver functions.
When shown to assign Excedrin, and what are the contraindications
It is strictly forbidden to drink tablets with hypersensitivity to any component of the composition, ulcers and erosions of stomach, intestinal and gastric hemorrhages, asthma of any type, in patients with recurrent polypose in the nose and sinuses, if an individual allergic to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs.
Not prescribed Excedrin before and after surgery, with bleeding of obscure origin, hemophilia, glaucoma, lack of vitamin K, breast-feeding, increased nervous excitability, insomnia.
You cannot drink several similar drugs, the composition of which is based on paracetamol, acetylsalicylic acid and caffeine.
Children up to 16 years the drug is not prescribed because of the risk of Reye’s syndrome.
In gouty affections, colic, chronic post-traumatic symptoms while taking anticoagulant, hypoglycemic, analgesics and antipyretics – Excedrin tablets should be treated with caution.
Available from pharmacies without providing a prescription permission. If in the treatment of migraine pain not only persist, but worsen, the patient should contact the clinic to clarify the origin of pain and make an accurate diagnosis. When the drug is taken in appropriate dose, the human body gets a dose of caffeine equal to one Cup of coffee, and then you need to reduce the consumption of the drink to a minimum.
A suspected overdose should serve as a sufficient reason for an immediate hospital visit. Do not take Excedrin and alcohol at the same time, it increases the risk of hepatic complications and bleeding in the digestive tract.