23.01.2021

Kestin or Cetrin, which is more effective

Despite the general indications for use, Kestin and Cetrin are not completely interchangeable, therefore, the doctor should decide which antiallergic drug is best , depending on the age of the patient, the contraindications he has, and the tolerability of the therapy.

Both adults and children can suffer from allergies. To stop its signs, Kestin and Cetrin preparations are used.

Kestin

Kestin contains as a main component ebastine, which relates to blockers of histamine H1-receptors. The medication has an antiallergic effect, the effect of it lasts up to 2 days. Kestin shows almost no m-anticholinergic activity. It penetrates poorly into the central nervous system and does not have a strong sedative effect. Up to 90-95% of the accepted dosage is absorbed from the digestive tract. Passing through the liver, the drug is metabolized.

Kestin

After eating fatty foods, absorption of Kestin is accelerated, and the concentration in the body increases by 1.5 times. Up to 95% of the dose taken is associated with proteins. The half-life of an antihistamine varies from 15 to 19 hours, with renal dysfunction, it lengthens up to 23-26 hours, with impaired liver function – 27 hours. It is excreted mainly through the kidneys.

The Kestin treatment regimen is selected individually depending on the age of the patient:

Age Single dose in mg
6-12 years old 5
12-15 years old 10
Over 15 years old 10-20

Kestin should be drunk once a day. If the patient has impaired liver function, then the daily dosage should not exceed 10 mg.

Cetrin

Cetrin contains cetirizine as the main component , which belongs to the blockers of H1 histamine receptors and metabolites of hydroxyzine. It is a competitive histamine antagonist. Cetirizine prevents the occurrence of allergies and facilitates its course, relieves itching, has an antiexudative effect, and almost does not have an anticholinergic and antiserotonin effect. The medicine reduces capillary permeability and eliminates spasm of smooth muscle tissue. Ceterizine suppresses the skin reaction to histamine, cold and specific allergens, prevents tissue swelling. It eliminates bronchospasm with a mild form of bronchial asthma.

Cetrin

If the medicine is taken in therapeutic doses, it almost does not have a sedative effect. After a single dose of Cetrin, the effect of it begins after 20 minutes and lasts up to a day.

When taking the drug in courses, addiction to it does not occur. After the therapy is over, the effect of the drug lasts for 3 days.

When taking Cetrin, it is rapidly absorbed from the digestive tract, its highest content is observed after an hour. Food does not alter absorption. But it lengthens the time to reach the maximum level by an hour and reduces the content of the drug by 23%. Up to 93% of the accepted dosage combines with proteins, so the medication is not removed during hemodialysis. The medicine in the body does not accumulate. The drug is excreted unchanged mainly with urine and in a small amount with feces.

The half-life depends on the age of the patient:

Age Half-life
From six months to 2 years 3.1 h
From 2 to 6 years 5 h
6 to 12 years old 6 h
In adults 10 h

In the elderly, the half-life can increase by 50%, and due to deterioration in renal function, systemic clearance decreases.

With renal and hepatic insufficiency, the period of life is lengthened. Cetrine is secreted through the mammary glands.

The treatment regimen is selected individually, depending on the age of the patient and the dosage form.
Drops taken in the following dosages:

Age Daily dosage
From six months to a year 5 drops once a day.
From a year to 2 years 5 drops twice a day.
From 2 to 6 years 5 drops twice a day or 10 drops once a day.
Over 6 years old 10-20 drops once a day.

Drink syrup in the following doses:

Age  Daily dosage
2-6 years 5 ml once a day or 2.5 ml twice a day.
Over 6 years old 10 ml once a day or 5 ml twice a day.

Tablets for patients over 6 years of age can be taken either 5 mg twice a day or 10 mg once a day.

With pathology of the kidneys of moderate severity, the daily dose is reduced to 5 mg.

General characteristics of drugs

Kestin and Cetrin have the following similarities:

  1. Both medicines are used for allergic rhinitis and conjunctivitis, urticaria.
  2. Antiallergic drugs are not possible with intolerance to their composition, during pregnancy and lactation.
  3. With caution, Kestin and Tsetrin should be drunk in chronic renal failure.
  4. Antihistamines are sold over the counter.
  5. Both drugs can cause dry mouth, insomnia or drowsiness, cause headaches and abdominal pains, upset stomach, bloating.
Differences between Kestin and Cetrin

There are many differences between Kestin and Tsetrin:

Kestin Cetrin
The country of manufacture Spain. India.
Release form Drops, tablets, syrup. Syrup, lyophilized and coated tablets.
Application area Hay fever, Quincke’s edema, atopic dermatitis and neurodermatitis.
Contraindications With caution, an antihistamine should be drunk with liver dysfunction. Use cetrine with caution in older people, as they may have impaired renal function.
Pediatric Use In the form of syrup, it can be used in children over 6 years of age; in tablets, the drug is recommended for patients over 12 years of age. Drops are allowed for children older than 6 months, syrup can be from 2 years old, tablets from 6 years old.
Effect on ability to drive a car The medicine does not affect the ability to drive a car. Cetrin can cause drowsiness and other adverse reactions from the central nervous system, so it should be used with caution for drivers and patients whose activities are associated with potentially dangerous equipment.
Adverse reactions Asthenia, sinusitis, dizziness, impaired sensitivity, palpitations, menstruation, swelling, deviation of liver function tests.
Drug interaction It is not recommended to be taken simultaneously with erythromycin and ketoconazole. When prescribed with theophylline, the total clearance of cetirizine decreases. Myelotoxic drugs enhance the hematotoxic properties of Cetrin.
Shelf life The syrup is suitable for 24 months, tablets – 36 months. Drops are valid for 36 months, syrup and tablets – 24 months.
Storage conditions The drug must be stored at temperatures up to 25 degrees, but the syrup cannot be kept at temperatures below 15 degrees. The medicine does not lose its therapeutic properties if stored at temperatures up to 25 degrees.

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