Both drugs are highly effective in the treatment of bacterial infections. Amoxiclav perfectly copes with diseases of the ENT organs (chronic otitis media, sinusitis, bronchitis), organs of the genitourinary system (cystitis, prostatitis, endometritis), with the risk of infection after animal bites, skin diseases. But mainly it acts on infections caused by gram-negative bacteria. It should be used with caution in people who have problems with the gastrointestinal tract, impaired liver and kidney function, nursing mothers, pregnant women, and preschool children. In such cases, the priority choice is Ecoclave.
In any case, it must be remembered that such drugs should be taken only as prescribed by the doctor with strict adherence to the dosage and time of administration.
Antibiotics not so long ago, but firmly entered into human life. This discovery, truly the greatest in the history of mankind, made it possible to effectively deal with previously considered incurable diseases that are caused by extremely dangerous bacterial infections.
Over time, doctors found that when taking these drugs, bacteria develop resistance to them, so there was a need to create new means of combating dangerous microorganisms. So antibiotics of a wide spectrum of action appeared in the form of combined preparations. Such drugs include Amoxiclav and its analogue, Ecoclave.
This semi-synthetic antibiotic is one of the top-selling drugs. It contains two active substances: amoxicillin and clavulanic acid.
Amoxicillin is an antibiotic of the penicillin group. With a wide spectrum of action, it has a structure that is quite vulnerable to individual bacterial strains. As a result, their resistance to the drug may occur. To eliminate this drawback, Beecham, a British manufacturing company, decided to combine amoxicillin with clavulanic acid.
Clavulanic acid, in addition to its ability to stimulate antimicrobial immunity, is a high-quality inhibitor, and this enhances the stability of amoxicillin.
As auxiliary substances, citric acid, sodium citrate, xanthan gum, sodium saccharin, etc.
This combination allowed us to expand the range of antibacterial effects created by Amoxiclav on bacteria that cause infectious diseases. The drug fights against such types of microorganisms as:
- Haemophilus influenzae.
- Brucella and others.
Amoxiclav is prescribed for:
- Diseases of the lungs and upper respiratory tract.
- Infectious skin diseases.
- Gynecological, urological diseases.
- Cholecystitis and cholangitis of an infectious etiology.
- Bone and connective tissue infections.
The drug is also used to treat wounds, phlegmon, as well as in dental practice.
- Hypersensitivity to substances in the composition of the drug.
- Severe liver failure.
- Mononucleosis and lymphocytic leukemia of infectious origin.
- The presence of a history of impaired liver function when using the active components of the drug.
Side effects are most often associated with a violation of the functions of the gastrointestinal tract: dyspepsia, abdominal pain, diarrhea, nausea. Less commonly, liver dysfunctions, anemia, leukopenia, dizziness, insomnia, allergic reactions, etc.
Amoxiclav is available in the form of tablets, suspensions and a solution for intravenous injection.
The active substances – amoxicillin and clavulanic acid – in the same proportions as Amoxiclav.
Excipients: lactulose, aspartame, xanthan gum, citric acid, sodium citrate, etc.
Indications for use and contraindications are also similar.
Side effects are rare, mostly mild. Dyspepsia, headache and dizziness, allergic reactions, leukopenia, anemia, etc. may occur.
Release form – coated tablets, powder for use as a suspension.
What is common between Amoxiclav and Ecoclave
So, both drugs have the same qualitative and quantitative composition of the active components, are effective broad-spectrum antibiotics, are able to cope with both gram-positive and gram-negative microorganisms. Both are well tolerated and have similar contraindications, in the form of suspensions can be used if necessary even for children of the first year of life.
Differences between them
Amoxiclav in various dosage forms is manufactured by Lek, Slovenia and Santos, Austria. Therefore, its price is significantly higher than the Ecoclave produced in Russia.
The effect of drugs on bowel function
It is known that antibacterial drugs affect not only pathogenic microorganisms, but also have a negative effect on the intestinal microflora, which performs functions that are vital for the human body. When prescribing Amoxiclav to the patient, the use of expensive probiotics is simultaneously recommended. This is necessary to mitigate the negative side effects manifested by the symptoms of dysbiosis: dyspepsia, diarrhea, nausea, vomiting, abdominal pain and other disorders associated with inhibition of intestinal microflora.
Ecoclave belongs to the innovative group of ecoantibiotics, which are equal to the original drugs for antimicrobial action, the composition of active substances, but surpassing them in safety. As an auxiliary component, a highly purified lactulose, which is the most effective prebiotic, has been introduced into the composition of the drug. It not only helps to maintain the intestinal microflora by inhibiting pathogenic bacteria, but also stimulates the immune system and the synthesis of vitamins. In addition to lactulose, the composition of the drug contains ascorbic acid (vitamin C) – an antioxidant that increases the body’s resistance.