The drug can not be prescribed to persons with individual intolerance, angioedema, Lapp lactase deficiency. Contraindicated in individuals with sugar malabsorption syndrome, hereditary galactose intolerance. It is not used to treat children, pregnant.
They are never used to treat patients with a narrowed lumen of a single kidney artery, or with a narrowed lumen of the renal arteries. The simultaneous use of the substance “alexiren”, which is part of various drugs, is prohibited.
It is contraindicated for persons with individual intolerance to one of the components of the composition, with angioedema caused by the use of ACE inhibitors. Do not prescribe to pregnant / planning a pregnancy, nursing or children.
Perineva is recommended for people with the following indicators:
- Persistent hypertension.
- Violation of cerebral circulation (to prevent re-stroke).
- Myocardial insufficiency of a chronic form.
- IHD (stable form).
- Myocardial-vascular complications (consequences of a heart attack).
Prestarium is indicated for persons with a diagnosis of:
- Cerebrovascular disease, possible repeated strokes.
- HF (heart failure).
- AH (arterial hypertension).
- IHD, which is fraught with myocardial infarction and heart failure.
Prestarium is never used to quickly stop the hypertensive crisis and lower blood pressure. It is used in the treatment of the elderly.
Perindopril is a substance that affects the normalization of the cardiovascular system. It is used to treat hypertension of various degrees. Effective for the prevention of strokes, heart attacks. It is found in the composition of “Perinev” and “Prestarium”. Complementing with other substances, makes each drug useful in the fight against the above pathologies.
Perineva
The drug is in the form of tablets under a film membrane. Each of them contains perindopril erbumin – the main active ingredient. The composition differs in the amount of the main substance: 2 mg, 4 mg, 8 mg. Perindopril Erbumin is combined with additive components, one of which is milk sugar.
The drug refers to ACE inhibitors. This is a group of natural and synthetic chemical compounds used for the treatment and prevention of cardiac / renal pathologies, lowering blood pressure.
The main action of Perineva is vasodilation, lowering of pressure, cardioprotection. The main substance reduces the indicators of diastolic, systolic pressure, increasing the speed of blood flow. In this case, heart rate does not increase. In parallel with blood pressure decreases OPSS.
Significantly improved blood flow in the kidneys, while the filtration rate remains unchanged. The therapeutic effect of the drug occurs after 5 hours and continues throughout the day, if counted from the time of use.
In order for the blood pressure indicators to establish, it will take 4 weeks of treatment. Then the patient experiences stable pressure for a long time.
The drug increases the elasticity of the walls of large arterial vessels. Eliminates structural changes in the small vessels of the circulatory system. Normalizes the myocardium, reducing various loads.
The drug is combined in the complex treatment of heart failure. Indicators:
- OPSS decreases.
- The cardiac index is increasing.
- Myocardial discharge is becoming more frequent.
- The pressure decreases in the ventricles of the myocardium.
Tablets are consumed in the morning, before breakfast. The dosage is selected by the doctor individually. The average daily dose for hypertension is 4 mg.
Common adverse reactions:
- CCC : a sharp decrease in blood pressure.
- Respiratory system : shortness of breath, cough.
- Gastrointestinal tract : pain in the epigastric region, nausea, vomiting, diarrhea, constipation, dry mouth, taste disturbance.
- CNS : headache with episodes of dizziness, feeling tired, refusal to eat, impaired hearing, vision, convulsive conditions.
- Skin : rashes accompanied by itching.
It is important to adhere to the selected dose of the drug, otherwise the pressure may drop dramatically, a shock condition may develop. A sharp increase in potassium and a decrease in sodium in AK is fraught with: renal failure, hyperventilation of the lungs, heart palpitations, bradycardia, anxiety, suffocation, dizziness.
Prestarium
The drug is available in tablet form. Each of them contains perindopril arginine – the active substance. It is supplemented with chemical and other substances, one of them is lactose.
The color of the tablets differs depending on the amount of the main substance inside. If they contain 2.5 mg, the surface will be white and the shape is round. 5 mg tablets are light green, oblong. At 10 mg – dark green, round. All of them are coated with an enteric film.
Prestarium is considered an ACE inhibitor.
The main effect of the drug is a decrease in blood pressure, regardless of what degree: mild, moderate, severe. The decrease applies to systolic and diastolic blood pressure.
The drug reduces the resistance of PS, which helps to lower blood pressure. Increases blood flow without increasing heart rate. Increases renal blood flow, without affecting the glomerular filtration rate.
Antihypertensive effect develops after 4-6 hours. It lasts a day. Blood pressure decreases gently and quickly. Over the course of a month it normalizes. It is stored for a long time. Cancellation syndrome does not occur.
Prestarium helps restore left ventricular hypertrophy. It is proved that the active substance dilates blood vessels, improves the elasticity of the walls of large vessels. Increases arterial lumen.
A single use is recommended in the morning, on an empty stomach. The dose is determined by the doctor.
What are the similar dosage forms
Both drugs improve the functioning of the CCC and kidneys. Indicated for the treatment and prevention of high blood pressure. Protect from heart attack, stroke. Effective in treating obese people; those with diabetes || degrees; seniors. They have many side effects.
What is the difference?
Perineva comprises erbuminovuyu salt and Prestarium – arginine. The latter refers to more modern drugs. Although the action is equally effective. Here, more emphasis is placed on the individual tolerance of a particular salt.
Available in one form, but contain various combinations, the quantitative content of the main substance. The choice of dosage remains with the attending physician, which takes into account the patient’s age, concomitant diseases and clinical indicators.
