Promis is a modern anti-ulcer drug Indian production, necessary for treatment and prevention of recurrence of diseases of the digestive tract.
The active ingredient and dosage form of Promes
The biologically active component of the drug is omeprazole. The medication comes in pharmacies in the form of capsules Packed in blisters of 10 or 14 pieces.
Pharmacological properties
Omeprazole belongs to the so-called blockers “proton pump”. In the tubules of parietal cells it inhibits the synthesis of hydrochloric acid in its final stages. Because of this, significantly reduces the overall acidity of the stomach, which promotes fast scarring of erosive and ulcerative defects of the mucosa.
The increase in gastric pH increases the sensitivity of the bacterium Helicobacter pylori to antibiotics during the eradication therapy. Receiving pharmacological properties reduce the frequency of recurrence of abnormalities and prevents the development of bleeding from the gastrointestinal tract in peptic ulcer disease.
After prima capsule inside the omeprazole is rapidly absorbed and reaches the parietal cells. The level of binding to blood plasma proteins is 95%. The metabolism of the drug occurs in the liver. Up to 80% of metabolites and unchanged substance is excreted in the urine, and the remainder from jelchew. The half-life in healthy individuals is 30 to 60 minutes. It significantly increases in patients suffering from severe pathologies of the liver.
Indications for Promes
Blocker of the enzyme H+/K+-ATPase is indicated for diseases of the gastrointestinal tract:
- ulcerative b-none of the stomach and 12 duodenal ulcer in acute phase;
- GERD;
- syndrome zollingerellison;
- pathology associated with infection by Helicobacter pylori;
- defects in the walls of the digestive tract, formed on the background of long-term treatment of NSAIDs and other drugs that stimulate the secretion of HCl.
Contraindications
A definitive contraindication for receiving Promes an individual sensitivity of the patient to omeprazole and additional substances of capsules.
The drug is not prescribed to patients with a pronounced functional insufficiency of the liver.
Children medication is not given, as experience in this age group is insufficient.
Dosage and admission rules Promes
Capsules need to be swallowed whole, with sufficient liquid.
The dose and the duration of the course of therapy is determined by the expert gastroenterologist, depending on the type of disease, symptoms, pathology, and the dynamics of the process.
The usual dose is 20 to 40 mg of omeprazole, and the maximum allowable daily – 80 mg. Ratio – 1 to 2 times a day. The drug is recommended to drink in the morning on an empty stomach or during meals and in the evening.
The total duration of therapy is from 2 to 8 weeks.
When eradication treatment to kill Helicobacter pylori, Promes drink simultaneously with two antibiotics twice a day.
Side effects
In most patients, Promes not cause any side effects. Hypersensitive to omeprazole and (or) additional components capsules it is not excluded hypersensitivity reactions immediate type (allergies).
In some cases:
It is important
General blood count may reveal thrombocytopenia, and anemia eosinopenia. Very rarely in patients receiving medications may be determined by protein in the urine.
Overdose
Cases of overdose not described Promes.
Promes during pregnancy and lactation
In clinical trials, a threat to the fetus properties of omeprazole have not been identified. However, women during pregnancy take this medicine is highly undesirable. If necessary, treatment in the period of breastfeeding of the child is transferred to the artificial mixture.
Promes interaction with other drugs
Amid simultaneous reception do not increase the toxicity of drugs, their clinical and pharmacological group of benzodiazepines.
Promes may reduce absorption of antifungals (Itraconazole, Ketoconazole).
Simultaneous treatment with the antibiotic Clarithromycin causes an increase in concentrations of both drugs in the blood.
In parallel with bismuth tripotassium dicitrate is not excluded by the undesirable increase in the concentration of bismuth in the body.
Omeprazole is able to prolong the effect of Atracurium bezilata.
Special instructions
Before taking Promes it is advisable to conduct a survey of the patient to exclude malignant lesions of the gastrointestinal tract, since drugs of this clinico-pharmacological group can “lubricate” the symptoms of cancer, which significantly hinders their early detection.
The drug can cause sudden dizziness, so at the time of treatment is strongly advised to refrain from working with potentially dangerous machinery.
On the background of the course receiving Promes not eliminated the distortion characteristics of plasma concentrations of gastrin.
Storage conditions and dispensing in pharmacies
Promes listed in “list B”, so to purchase need a prescription.
The medication is stored at a temperature not exceeding 25° C.
Keep away from children!
Allowable storage period is 2 years from the date of issue, marked on the original packaging.
