Phenibut and Afobazole, drug choice

After considering the presented drugs, it is difficult to say which one is better or more effective. Moreover, they are not analogues.

If a person has increased vulnerability, anxious suspiciousness, overly emotional reactions, insecurity, it is better to choose Afobazol. But provided that such conditions are moderate and there is no violation of the blood circulation of the brain.

If anxiety is pronounced and accompanied by a disorder of cerebral blood flow, the drug of choice will be Phenibut. It must also be chosen for the treatment of the child.

But, I would like to remind you that a doctor should prescribe drugs.

There are frequent cases when it is advisable to use both medicines. In such cases, the dosage and duration of therapy are established by a specialist for each patient individually.

The number of people suffering from various types of nervous disorders is growing steadily every year.

Chronic overwork, prolonged psycho-traumatic situations, family troubles – this is only part of the negative factors leading to disruption of the central nervous system.

With psychosomatic manifestations, it is necessary to start the fight as early as possible. Otherwise, serious organic pathologies can occur due to nervous disorders.

Modern pharmacology today represents a large selection of medications that can adjust the functioning of the nervous system.

These include drugs often prescribed by doctors – Phenibut and Afobazol.

“Phenibut”: characteristics of the drug

“Phenibut” is a medicine from a number of nootropics. It also has anxiolytic and mild psychostimulating effects.

It has been used in medical practice since 1975 for the treatment of mental disorders and nervous diseases.

The main active ingredient is aminophenylbutyric acid hydrochloride.

Among the minor ingredients are: milk sugar, potato starch, calcium stearate.

In pharmacies, there is a tablet form of the release of the drug, with a content of 250 mg of the active substance per tablet. The drug can sometimes be found in powder form, with a dosage of 100 mg.

It is produced by various pharmaceutical enterprises of the countries of the former USSR. Production is carried out in the Republic of Belarus, Latvia, Russia.


Indications and contraindications

Phenibut is prescribed if a person has the following conditions:

  • Psychopathy.
  • Asthenic syndrome.
  • Baseless fear and a sense of anxiety.
  • Otogenous labyrinthitis.
  • Psychoneurosis.
  • Insomnia, nightmares in the elderly.
  • Meniere’s disease.
  • Dizziness associated with vestibular dysfunction.
  • Children’s enuresis.
  • Stuttering in a child.
  • Tics of different origin in children.
  • Withdrawal syndrome.
  • Urinary retention due to myelodysplasia.
  • Speech disorders (in adults).
  • Impaired functioning of the vessels of the brain.
  • VSD.
  • Migraine.
  • Open-angle glaucoma (as part of complex therapy).

Often used as a means of sedation before surgical interventions and invasive diagnostic procedures.

Contraindications to the use of this medication are: age up to 8 years. allergic to components. period of breastfeeding. pregnancy.

It should be used with caution in patients with gastrointestinal diseases (erosion, ulcers) and liver failure.

Like most nootropics, Phenibut is well tolerated by patients. Side effects are rare. Sometimes nausea, irritability, headache, drowsiness, allergic manifestations, and skin rash are possible.

As a rule, such reactions are due to exceeding the recommended dose or prolonged use of the pharmaceutical product.

pharmachologic effect

The pharmacological effect of drugs (drugs) is to affect the blood flow of the brain, increasing its volumetric rate. In addition, the active substance of the drug helps to stabilize metabolic processes in the brain tissues.

Due to the presence of antiplatelet properties of drugs, the tone of the cerebral vessels decreases, microcirculation improves, and the ability to adhere platelets decreases. This leads to improved blood circulation in the brain.

The tranquilizing effect, which also has a pharmaceutical product, can reduce the severity of asthenia and vasovegetative symptoms. Moreover, the well-being of patients improves markedly in the first days of treatment.

A course medication allows you to achieve normalization of sleep, reduce anxiety, reduce headaches and heaviness in the head.

Psychological indicators are also improving. The memory becomes stronger, the working capacity (mental and physical) is increased, the emotional background is normalized.

The activity of the brain is activated, as a result of which patients find the optimal solutions to various problems easier and faster. Increases motivation and interest in various activities. The speed and accuracy of psychomotor reactions improves.

To achieve a lasting therapeutic effect, Phenibut is prescribed in courses lasting from 2-3 weeks to 2 months. The duration of treatment and the dose of the drug are determined by the doctor, depending on the onset of stabilization.

If necessary, courses can be repeated, but the intervals between them should be at least 3-4 weeks.

Afobazol: characteristics of the drug

Afobazole is an anxiolytic (tranquilizer), not included in the benzodiazepine group. It has been present on the domestic pharmacological market since 2000. So it is considered a completely “young” drug.

This medicine is intended for the treatment of various anxiety conditions.

It has a calming ( anti-anxiety ) and mild stimulating effect.

Afobazole was synthesized in Russia by the Institute of Pharmacology of the Russian Academy of Medical Sciences. It is a selectively acting tranquilizer, which, thanks to the efforts of scientists, was deprived of the negative side factors inherent in benzodiazepines, the main group of anti-anxiety medications.

The main component in the composition of the drug is fabomotizole. Auxiliary ingredients include: collidone, MCC, polyvidone, lactose, etc.

The medication has only one form of release – tablets containing 5 mg and 10 mg of fabomotizole.


Indications and contraindications

It is prescribed for the treatment of such anxiety conditions as:

  • Asthenic neurosis.
  • Social maladaptation.
  • Anxious neurosis.
  • Somatic diseases (lupus erythematosus, bronchial asthma, IBS, ischemia).

Also used to treat:

  1. Neurocirculatory dystonia.
  2. ICP.
  3. Anxiety related sleep disorders.
  4. Alcohol withdrawal.
  5. To mitigate the severity of the “withdrawal” syndrome that occurs when tobacco is abandoned.

Contraindicated in galactosemia, lactase deficiency, allergies to any substance in the composition of the drug, pregnant and lactating women, persons under 18 years of age.

Side effects in most cases are caused by individual reactions of the patient’s body to the components of the drug and are expressed by allergic manifestations in the form of urticaria, skin itching, dermatitis, rhinitis, etc.

Sometimes nausea, stool disturbance, vomiting, headache can occur.

pharmachologic effect

The pharmacotherapeutic effect of the drug is to stabilize receptor membranes sensitive to aminobutyric acid. It prevents the development of the process of membrane dependence in them.

In addition, due to its neuroprotective properties, the drug protects nerve cells from damage and increases their bioenergetic potential.

Due to the combination of the anti-anxiety and stimulating effects of the pharmaceutical agent in patients during the treatment, a decrease in anxiety and concern was noted.

The ability to relax improved, fears, tearfulness disappeared, and the quality of sleep improved.

The manifestations of vegetative disorders (hyperhidrosis, dizziness) were smoothed out. Cognitive functions improved.

The effect of taking begins to appear after about 1 week, and reaches a maximum after 1 month. Usually the recommended course is 3-4 weeks. But in some cases, the duration of admission may be 3 months. This issue is decided by the attending physician.

There are certain similarities between the two medicines presented.

What are the drugs like?

Both pharmaceuticals are synthesized in our country. They are produced in the same form of release. They have a similar therapeutic effect – relieve anxiety and fears.

Similar features include their ability to withstand damage to nerve cells and increase their resistance to various damaging factors.

Both have a calming effect. By virtue of this, they can be prescribed for similar pathologies.

The medications in question have a number of identical contraindications to taking.

What’s the Difference

Pharmaceuticals differ in the following indicators:

  1. The main difference is the different active components.
  2. They belong to various pharmaceutical groups. Afobazol is a tranquilizer (anxiolytic), Phenibut is a nootropic.
  3. Also, the mechanism of action is not the same. The anxiolytic effect of Afobazole is carried out on the subcortical structures of the brain responsible for the emotional state. Due to this, a person calms down. Nootropic, in addition to relieving stress, improves blood circulation in the brain.
  4. The effect of taking Phenibut develops faster. The second pharmaceutical product demonstrates healing properties only after a week.
  5. Afobazole has fewer side effects.
  6. Prolonged and illiterate intake of Phenibut can be addictive. His “counterpart” is deprived of such negative qualities.
  7. A nootropic agent can irritate the gastrointestinal mucosa. In this regard, anxiolytic is safer.
  8. Phenibut is a strictly prescription drug. The second remedy in pharmacies is free.
  9. There is a difference in age indications for admission. Phenibut, although it is considered an obsolete drug, is approved for use in childhood. The second medication is prescribed only for adult patients.

Prices for pills also vary significantly. “Phenibut” – from 64 to 380 rubles. (depending on the number of tablets in the package and the country of manufacture). Afobazol – from 380 to 550 rubles.

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