21.10.2020

Gliatilin or Cerebrolysin, drug choice

The doctor should decide what is best for Gliatilin and Cerebrolysin, since nootropic drugs are not completely interchangeable and each medication has its own indications and contraindications.

A wide range of nootropic drugs is on sale and it is sometimes difficult to choose which one is better. These medicines include gliatilin and cerebrolysin. Despite belonging to one clinical and pharmacological group, drugs have not only similarities, but also differences that need to be clarified before treatment.

Gliatilin

The drug is available in capsules and an injection solution that is injected into a muscle or vein. As the main component, the medication contains choline alfoscerate .

Capsules have an oval shape, they are soft and opaque, they contain a thick, colorless liquid. The injection solution is a clear, colorless liquid that does not smell anything.

Gliatilin

The composition of the capsules includes the following additional components:

  • Glycerol.
  • Water.
  • Gelatin.
  • E171.
  • E172.
  • E216.
  • E218.
  • E491.
  • Ezitol.

The composition of the injection solution includes water.

The drug refers to central cholinomimetics. It mainly affects the central nervous system.

The composition of the drug includes 40.5% of choline , which is released from the drug in the brain. Choline takes part in the formation of acetylcholine, which is one of the main neurotransmitters of excitation, it has a positive effect on the transmission of nerve signals.

Alfoscerate undergoes biotransformation to glycerophosphate, which is the precursor of phospholipids. It participates in the formation of phosphatidylcholine, which makes up the cell membrane, and as a result, its elasticity and receptor function are improved.

Gliatilin improves blood circulation and metabolism in the brain, helps its tissues recover after an injury, and has a positive effect on memory.

After oral administration, up to 88% of the dose taken is absorbed, easily penetrates the BBB, and is deposited in large quantities in the brain, lungs and liver. The drug is excreted mainly through the lungs in the form of carbon dioxide, in smaller quantities with urine and feces.

The drug does not adversely affect the reproductive cycle, does not show teratogenic and mutagenic effects.

Gliatilin is used in the presence of the following health problems:

  • The acute stage of traumatic brain injury, in which stem lesions are predominantly observed (the drug can be used when the patient has a disorder of consciousness and coma).
  • Circulatory disturbance in the brain.
  • Vascular dementia.
  • Changes in behavior and emotions: frequent mood changes, irritability, apathy, pseudomelancholy in the elderly.
  • Violation of speech, memory, concentration of attention caused by a disorder of cerebral circulation and the natural aging of the body.

Norm of reaction of urine (pH)

Cerebrolysin

Cerebrolysin is available as an amber-clear, injectable solution. As the main component, it contains a complex of peptides that are obtained from the brain of pigs. In addition to it, the composition of the medicine includes caustic soda and water.

Cerebrolysin

Cerebrolysin contains neuropeptides that penetrate the BBB and enter the nerve cells.

The drug improves metabolism in the brain, protein formation, both in children and in the elderly. It protects neurons from the damaging effects of lactic acidosis and excitatory amino acids, prevents the formation of free radicals, the death of neurons due to oxygen starvation and ischemia.

The medication has a positive effect on memory and memory processes.

Cerebrolysin is used for the following pathologies:

  • Alzheimer’s disease.
  • Dementia
  • Chronic cerebrovascular accident.
  • Injuries to the brain and spinal cord.
  • Ischemic stroke.
  • Depression in which antidepressants are ineffective.
  • Mental retardation in children, lack of attention and hyperactivity in minors.
What are the similar means

Gliatilin and Cerebrolysin have the following similarities:

  1. Both medicines can be used in cases of cerebrovascular accident and dementia, after an injury.
  2. During treatment, they improve blood circulation in the brain, memory, concentration.
  3. Medicines should be stored in a dark place inaccessible to children at temperatures up to 25 degrees.
  4. Nootropics can not be used with individual intolerance to their composition.
  5. They can cause allergies.
Comparison and differences

Gliatilin and Cerebrolysin have the following differences:

Gliatilin Cerebrolysin
Thomas release Capsules, solution for injection and infusion. Injection solution.
Producing country Italy. Austria.
Use in children’s practice The drug is intended for adults only. Cerebrolysin can be given to children with mental retardation and hyperactivity.
Use during pregnancy and lactation The medication is contraindicated in pregnant and lactating patients. After assessing the benefits for women and harm to the child or fetus, the drug can be pregnant and lactating.
Overdose  Taking capsules in large doses can cause nausea. With parenteral administration, nausea, abdominal pain, and confusion are possible. To date, there have been no cases of drug overdose.
Contraindications The drug is prohibited for patients with acute renal failure and status epilepticus.
Adverse reactions Treatment with the drug can cause nausea, in which case you need to reduce the dosage. If the drug is administered too quickly, then a sensation of fever, vertigo, increased sweating, tachycardia, and heart rhythm disturbances may occur.

In addition, during therapy, nausea, vomiting, constipation, lack of appetite, diarrhea, stool retention, aggression, insomnia, confusion, convulsions, epileptic seizures, redness of the skin, itching and burning at the injection site, hyperventilation, or low blood pressure, fatigue, depression, apathy, flu-like syndrome.

Shelf life Capsules are valid for 36 months, ampoules can be used 5 years from the date of issue. Ampoules are suitable for 5 years, bottles for 4 years.
Drug interaction Clinically significant interaction of Gliatilin with other medicines has not been established. When Cerebrolysin is co-administered with monoamine oxidase inhibitors and antidepressants, mutual enhancement of effects is possible, which may require dosage adjustment.

Nootropic and amino acids, lipids, and medications that change the pH of the medium cannot be mixed in a single infusion solution.

Cerebrolysin can be mixed with saline, Ringer’s solution and 5% glucose.

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