Goldline and Reduxin, drug selection

Sibutramine-based drugs are included in the list of potent substances, which is approved by the Government of the Russian Federation and are dispensed strictly according to a doctor’s prescription, so they are not allowed to self-medicate.

Only a specialist can decide on the appropriateness of their appointment, depending on the availability of indications and contraindications, as well as tolerance to therapy.

Reduxin and Goldline are used to treat obesity when non-drug methods to lose weight do not help. Despite the general indications, the preparations have a number of differences and features that are important to know before you start taking them.

Goldline

The medicine is available in capsules of 10 mg and 15 mg. The therapeutic effect of the medication is explained by sibutramine.

Goldline 10 mg is available in capsules with a yellow body and a blue cap. 15 mg capsules have a white body and a blue cap. Inside they contain white or almost white powder.

In addition to sibutramine, the drug contains the following indifferent substances:

• Milk sugar.
• MCC.
• Aerosil.
• E576.

The capsule is formed by the following substances:

1. Case: E171, gelatin, sodium lauryl sulfate. In addition to them, 10 mg capsules contain E104 and E110.
2. Cover: gelatin, dyes blue diamond and fuchsin acid, E171, sodium lauryl sulfate.

Sibutramine increases the content of neurotransmitters in synapses , as a result of which the activity of brain receptors increases, this leads to a feeling of satiety and a decrease in daily calorie content. Weight loss is accompanied by an increase in HDL in the blood and a decrease in the concentration of fats, bad cholesterol and uric acid.

After oral administration, up to 77% of the drug is absorbed in the digestive tract . Passing through the liver, sibutramine is metabolized. The active substance is rapidly distributed throughout the tissues, up to 97% of the accepted dosage binds to plasma proteins.

The half-life of its metabolites reaches 16 hours. The medicine is excreted mainly with urine.

Reduxin

Reduxin contains sibutramine and microcrystalline cellulose (MCC) as active components . It is available in capsules. The drug is in dosages of 10 mg and 15 mg.

Capsules of 10 mg in blue, 15 mg in blue. Inside, they contain a white powder, which may be a yellowish tinge.

As an additional component, the drug contains calcium stearate.

The capsule shell is formed by gelatin and titanium white, in addition, the 10 mg medication contains diamond blue and azorubine dyes, and the patented blue dye is part of the 15 mg medicine.
MCC refers to enterosorbents, it binds and removes microbes from the body, their metabolic products, endogenous and exogenous harmful substances, allergens, xenobiotics, end products of metabolism that can cause intoxication.

Similarities of funds

Reduxin and Goldline have the following similarities:

• Both medicines are prescribed for overweight patients if their body mass index is at least 30 kg / m ², as well as for diabetics and people with dyslipoproteinemia when their BMI is equal to or greater than 27 kg / m ².
• Along with taking both drugs, allergies, sleep disturbances, headaches, dizziness, sensory disturbances, anxiety, palpitations, hypertension, signs of vasodilation, exacerbation of hemorrhoids, dry mouth, delayed stool, lack of appetite and vice versa, it may increase, can occur. nausea, taste perversion, excessive sweating, thirst, swelling, menstruation pain, abdominal pain, back pain, mood swings, itching, increased activity of liver enzymes, decreased thrombotic level itov, convulsions, bleeding, bleeding under the skin, flu-like symptoms, depression, drowsiness, anxiety, irritability, nervousness, schizoaffective disorder, tubulointerstitial nephropathy. When you stop taking, withdrawal reactions may occur,
• It is forbidden to drink drugs if there is an organic cause of obesity, for example, associated with hypofunction of the thyroid gland. Medications are contraindicated in patients with anorexia nervosa or bulimia, mental disorders, generalized tics, pathologies of the cardiovascular system, high blood pressure that cannot be normalized with drugs, severe impaired liver and kidney function, prostate adenoma, drug, drug and alcohol dependence, thyrotoxicosis, fe, intolerance to the composition of the capsules, angle-closure glaucoma. Capsules should not be drunk for patients under the age of 18 and over 65 years old, women in position and supporting breastfeeding, people who receive treatment with medicines that affect the central nervous system, tryptophan-based drugs, MAO inhibitors. Reduxin and Goldline should be taken with caution in the presence of a history of arrhythmia, chronic circulatory failure,

Comparison and differences

Medicines have the following differences:

1. The shelf life of Reduxine is 36 months, and Goldline is 24 months.
2. Reduxin can cause atrial fibrillation, short-term memory impairment, veils in front of the eyes, mania, psychosis, suicide, hair loss, urinary retention, loose stools, vomiting, erectile dysfunction, premature ejaculation, and vaginal bleeding.
3. With caution, Reduxine should be drunk by patients with a tendency to bleeding, bleeding disorders, as well as people receiving medications that affect hemostasis and platelet function.