Indapamide belongs to drugs that reduce blood pressure due to diuretic action. It is used as an independent tool and as part of combination therapy. The therapeutic effect is not achieved immediately and begins about a week after the start of the intake.
Veroshpiron, like indapamide, has a diuretic and hypotensive effect, but it works on a different principle. A positive effect on the body begins as the work of aldosterone is corrected, on which the regulation of the amount of fluid and sodium in the body is most dependent. Veroshpiron affects the function of aldosterone, enhancing fluid excretion. Due to its weak diuretic effect, veroshpiron can be combined with other diuretics, such as indapamide.
Veroshpiron has a wider range of indications for use due to action at the hormonal level. Aldosterone belongs to the category of androgen hormones and a sharp increase in its level can cause excessive hair growth in androgen-dependent zones. Therefore, drugs containing spironolactone are often used to treat hirsutism and other female diseases caused by increased production of male hormone.
For decades, three first-line antihypertensive diuretics have been most popular – hydrochlorothiazide, indapamide and veroshpiron, or spironolactone. They became widely known at the end of the twentieth century and are well known to many consumers. Mass production of spironolactone analogues began later than all. Currently, they are known as having the greatest effectiveness and not bearing a threat to health.
Veroshpiron: general information
Veroshpiron belongs to the group of potassium-sparing diuretic drugs. Its use significantly affects the increase in urine output, that is, the amount of urine leaving the body throughout the day. The use of veroshpiron retains potassium ions in the body.
Veroshpiron is used to exit excess fluid from organs in a variety of cardiovascular diseases. The forms of release of veroshpiron include tablet and in the form of capsules. The main active ingredient in them is spironolactone, the following additional substances are also added: magnesium stearate, silicon dioxide, talc, lactose monohydrate and corn starch.
Indications for use of Veroshpiron:
- Essential hypertension, when blood pressure rises over time. This process occurs due to the retention of liquid and sodium salts in the bloodstream.
- Idiopathic hyperaldosteronemia, when the body rises a hormone called aldosterone, produced with the participation of atrial cells. This is the reason for insufficient fluid excretion and at the same time cases of swelling are frequent.
- Congestive heart failure, when the functional activity of the heart decreases. In this case, edema and insufficient fluid output from the urinary system occur.
- Liver cirrhosis, when liver cells are replaced by fibrotic connective tissue. In this case, congestive blood phenomena develop in large veins, liver failure, swelling and cessation of fluid exit from the body. Also, cirrhosis of the liver contributes to the development of secondary aldosteronism, when the level of the hormone aldosterone rises as a result of a decrease in its metabolism in the liver.
- Primary hyperaldosteronism. In this case, the medicine is used in preparation for the operation and after the operation.
- Hypokalemia, when the level of potassium in the blood decreases.
When Veroshpiron cannot be taken:
- If the patient does not tolerate the components of the drug or has an increased sensitivity to them.
- If there is acute kidney failure on the background of decreased urine output or its complete absence.
- If a person suffers from Addison’s disease.
- With excessive levels of potassium ions in the blood.
- During pregnancy and the period of breastfeeding.
- Children under the age of three years.
Indapamide: General Information
Indapamide belongs to the category of diuretics. It belongs to the group of thiazides. Known for its hypotensive, vasodilator and diuretic effects.
This drug is widely used for the treatment of hypertension both independently and as part of combination therapy. Release it in tablet form and in capsule form. The main active ingredient in the drug is indapamide. Auxiliaries include lactose monohydrate, povidone, crospovidone, magnesium stearate, sodium lauryl sulfate, and talc.
The benefits of indapamide for the body:
- Blood pressure decreases.
- The total peripheral vascular resistance decreases.
- Blood vessels dilate.
- The thickening of the wall in the left ventricle of the heart is reduced.
- The outflow of fluid increases.
Indapamide does not affect the metabolism of fats and carbohydrates, therefore, in the presence of diabetes and high cholesterol, patients can take it. In addition, indapamide has been shown to be effective in treating hypertension in people who have lost one kidney or are undergoing hemodialysis.
The main indication for the use of indapamide is the treatment of arterial hypertension in adults.
- The lack of potassium ions in the blood.
- Chronic renal failure.
- If the patient has not reached the age of eighteen.
- Hypersensitivity or individual intolerance to the components of the drug.
- Severe degree of liver failure or its complications.
What do veroshpiron and indapamide have in common
Veroshpiron and indapamide are popular and widely known drugs that are used to lower blood pressure. The main differences between them can be found in the mechanism of action, the presence of side effects and accessibility.
Which drug is considered the best and safer?
Indapamide has a lesser degree of negative reactions to other drugs. But with arterial hypertension, veroshpilactone still works better, which is proved by clinical studies involving volunteers. Both tools are quite affordable, so their cost is not a selection criterion.