Both are used in mucolytic therapy . Relate to synthetic drugs. They have several forms of release, which means they can be used in the form of inhalations, orally, endobronchial and as an injection. They have one therapeutic effect in bronchopulmonary diseases.
Do not use concomitantly with antitussive drugs. Combined with antibiotics.
Ambrobene is considered a mucolytic agent of a new generation. Under the influence of the drug, the natural defense of the lungs is enhanced. This occurs by activating tissue microphages and enhancing secretion production. The benefits of the drug are teratogenic effects. Therefore, it is used to treat pregnant, pediatric patients. The medicine is prescribed for preventive purposes and for the treatment of distress syndrome.
Fluimucil helps to thin the purulent exudate and remove it from the respiratory tract. The drug increases antiviral immunity, protects cells from free radicals that cause inflammatory reactions. May cause bronchospasm. Contraindicated in pregnant women, lactating. Do not use for patients during exacerbation of stomach ulcers and / or duodenal ulcers.
Ambrobene is used for violations of bronchial secretion and weakened progress of mucus. Do not use persons with individual intolerance to substances in the composition.
Fluimucil is suitable for patients with acute and chronic respiratory diseases, which are accompanied by profuse sputum formation. Do not prescribe to persons with a diagnosis of hypersensitivity to the main substance and other components, stomach ulcer and / or duodenal ulcer (exacerbation), pulmonary bleeding.
Coughing cannot be attributed to the disease. This is a symptom of one of the inflammatory diseases. Mucolytics are the basis of the component in the complex treatment of bronchopulmonary diseases.
For example, Ambrobene and Fluimucil. One and the other is widely used. Purpose: to inhibit the formation of bronchial secretions, thin it and remove sputum. That means providing free breathing.
In contrast to the forms of production, they provide various methods of substance delivery.
A synthetic drug, originating in Germany, is distinguished by a variety of release forms:
- 30 mg tablets (20 tabs).
- Capsules 0.075 mg (10 drops).
- Syrup 15 mg / 5 ml (100 ml).
- The oral solution is 7.5 mg / ml (40 or 100 ml).
All forms include the main active ingredient – Ambroxol hydrochloride in various proportions. The drug refers to mucolytic agents used for colds, accompanied by a cough.
Ambroxol hydrochloride has a mucolytic (thinning sputum) and secretory (expectorant) properties. Normalizes bronchopulmonary secretion. Under the influence of ambroxol, sputum (rheological) indicators improve. The viscosity of sputum is reduced, its discharge from the departments of the bronchi is facilitated. Increased production of surfactant in the lungs.
Ambroxol hydrochloride acts as an anesthetic at the local level by blocking neural sodium channels . Carries out anti-inflammatory effect, reducing pain and redness of the throat. This eliminates discomfort in the nose, ears, trachea when inhaling air. The drug increases the concentration of antibiotics in the bronchopulmonary secretion and sputum.
The positive side of the drug is a quick therapeutic effect . It comes in half an hour. It lasts about 12 hours.
The drug can not be used simultaneously with drugs that suppress antitussive activity. This will lead to a complication of sputum discharge from the bronchi. Works great in combination with antibiotics, improving their entry into the lung tissue.
In case of an overdose, excessive salivation, lowering blood pressure, nausea, accompanied by vomiting, were observed. In rare cases, agitation, diarrhea were noted.
On the part of some systems, side effects are detected:
- Urinary system: dysuria.
- Skin and skin: contact dermatitis, erythema, rash, lesions due to Lyell and Stephen-Johnson syndromes.
- Immune system: hypersensitivity, accompanied by a rash, angioedema, dyspnea, urticaria.
- Respiratory system: dryness of DP, rhinorrhea, pharyngeal hypesthesia.
- Gastrointestinal tract: disorders accompanied by nausea, vomiting, heartburn, dyspepsia, diarrhea, constipation.
Against the general background, there is the likelihood of a headache, fainting, chills, fever.
Synthetic preparation is available in Italy, Switzerland in the following forms:
- Granules for the preparation of a solution of internal use 200 mg (20 packs).
- Effervescent tablets 600 mg (10, 20 tab).
- Solution for injection, inhalation 10% 3 ml (5 amp).
- Fluimucil-antibiotic in ampoules (3 amp).
All forms contain the main active ingredient – acetylcysteine in various proportions. The drug belongs to mucolytic agents.
Acetylcysteine has a thinning effect on sputum, reduces the viscosity of mucus. The action extends to purulent sputum. Due to the neutralization of oxidative radicals, the drug acts as an antioxidant, a cytoprotector. Through this, oxidative processes in the cells are restored, toxins are removed from the body.
The therapeutic effect occurs after 1-3 hours . It lasts about a day.
Do not use simultaneously with cough medications, as sputum congestion is intensified. The action of acetylene is reduced by activated carbon.
It is important to know that the simultaneous use with tetracyclines, except Doxycycline, cephalosporins, aminoglycosides, cephalosporins, leads to a decrease in the activity of both drugs. The application interval must be observed – 2 hours .
Nitroglycerin in combination with acetylcysteine leads to a decrease in blood pressure, expansion of the artery in the temple.
No cases of overdose have been identified. Adverse reactions are accompanied by the following symptoms:
- Subcutaneous tissue, skin: rashes, Quincke’s edema, pruritus (infrequently).
- Gastrointestinal tract: epigastric pain, nausea, vomiting, stomatitis, vomiting (infrequently).
- CCC: tachycardia (infrequently); shortness of breath, spasm in the bronchi (rarely); hemorrhages (very rare).
- Hearing organs: ear ringing (infrequently).
- CNS: headache (infrequently).
- IP: hypersensitivity (infrequently); anaphylactic shock (very rare).
Common disorders include hyperthermia.