Larkson is a modern and highly effective antimicrobial and antiparasitic drug. It belongs to the group of beta-lactam antibiotics (cephalosporins third generation).
Dosage form active ingredient Lorexane
Bactericidal action of Ceftriaxone is realized by violation of the integrity of cell membranes of pathogenic microorganisms. An antibiotic effective against beta-hemolytic streptococci group A and a large number of gram-positive bacteria. It is also able to destroy gram-negative microorganisms resistant to ampicillin. Larkson-resistant strains of microorganisms able to synthesize a specific enzyme β-lactamase.
The drug is absorbed very rapidly and almost in full. When I/V injection maximum plasma concentrations are reached after 5-10 minutes, and when the/m – 30-45 minutes.
Half-life PM up to 8 hours in adult patients. Ceftriaxone is evenly distributed in tissues and biological fluids, bypassing the blood-brain and gematoplatzentarnyi barriers. The active component is found in breast milk. Antibiotics excreted mainly via the kidneys (60%) and intestine (about 40%) in nematerializiranih condition.
Testimony to start taking Lorexane
Cephalosporin is widely used in severe diseases of infectious origin – peritonitis, bacteremia, septicaemia and meningitis. Larkson indicated in patients with a low level of immunity.
Ceftriaxone is assigned, if it is diagnosed:
It is important
Larkson administered to patients in the postoperative period for prevention of infectious complications.
This drug should not be administered if the patient is diagnosed in parallel, renal and hepatic dysfunction.
Dose scheme and the introduction of
The required dosage is set by the attending physician strictly individually, taking into account such factors as the weight of the patient and his General condition. Powder diluted with sterile water for injection immediately before the procedure.
For intramuscular injections of 1 g of the antibiotic is diluted in 3-4 ml of distilled water. To reduce discomfort during the introduction instead of water you can use the novocaine (0,25-0,5%). The vial is thoroughly shaken to obtain a maximally homogeneous liquid. The drug is injected deep in the outer outer quadrant of the buttocks.
It is important
Already divorced Larkson at a temperature not exceeding + 25 C, stable for 6 hours.
At low immunity and severe General condition of the adult patients administered 4 g Lorexane per day.
If there are indications for the on/in the introduction of the jet, 1 g of drugs diluted in 10 ml of water for injection or saline, carried out the infusion for 3-5 minutes.
The duration of “normal” intravenous infusion is at least 30-40 minutes. To prepare the solution 2 g Lorexane dissolved in 40 ml of dextrose (5-10%) or isotonic solution.
The necessary duration of a course of treatment is determined by the attending physician taking into account the severity of symptoms and overall dynamics.
Side effects Lorexane
With injections Lorexane in rare cases, develop the following side effects:
A General analysis of the blood during the course of therapy shows neutropenia and lymphocytosis.
If the patient has severe renal dysfunction, and dose of antibiotic properly, it is possible tremor, encephalopathy, and seizures. Intravenous injection can cause phlebitis, and in violation of the rules of intramuscular abscess is not excluded.
In case of an accidental excess of the prescribed dose is not excluded increased side effects, and in particularly severe cases encephalopathy and coma development. In such cases it is necessary to maintain vital functions and conduct hardware blood purification (hemodialysis).
Larkson during pregnancy and breastfeeding
Larkson has no embryotoxic, mutagenic and teratogenic properties, however, it is advisable to appoint in the first trimester of gestation and during lactation because the active material easily passes gematoplatzentarnyi barrier and is found in breast milk.
Interaction with other drugs
On the background of treatment with Ceftriaxone antibacterial activity of aminoglycosides is enhanced.
In parallel NSAIDs increases the risk of bleeding.
Sharing with the so-called loop diuretics adversely affects the kidneys.
Larkson strictly forbidden to mix in the same system or syringe with other antibacterial agents.
The compatibility of the alcohol with Arakonam
Larkson and alcohol are incompatible. Make the drinks containing ethyl alcohol (including pharmacy tincture) during a course of antibiotics is strictly prohibited in order to avoid the development disulfiramopodobna reactions. The patient may fall the HELL to start vomiting and may appear spastic epigastric pain. After receiving Lorexane preferably a few days to refrain from taking strong drink.
The rules of storing and dispensing through pharmacies
Store vials at a temperature in the range from +5° to +25°C.
Keep away from children!
The shelf life of the antibiotic is 36 months. on the date specified on the original packaging.
Analogues Lorexane on the active substance and the therapeutic effect are:
We recommend you to read: Noraxon or Ceftriaxone: which is better?
Plisov Vladimir, doctor, medical commentator