Norkolut or Duphaston, the choice of drug

Both Duphaston and Norkolut perform the function of filling the deficiency of natural progesterone, however, there are still some differences:

  • Dufaston contains dydrogesterone, which, just, acts as an analog of progesterone. Manufacturer: Netherlands.
  • In Norkolut, this analogue is norethisterone. Manufacturer: Hungary. Very similar in mechanism of action.
  • Dydrogesterone is completely deprived of androgenic and estrogenic dynamics. It follows that taking this medication will not lead to changes inherent in the actions of these hormones.
  • Norethisterone, in turn, is endowed, but on a small scale, with the above hormones, so Norkolut is used only in cases of gynecological ailments, and Dufaston is used to treat infertility and pregnancy problems.
  • The drugs are available in tablet format. With endometriosis, after taking these drugs, the structure of the endometrium normalizes: pain disappears and blood loss decreases.
  • In general, both drugs affect the reproductive functions of a woman’s body.

What to choose? In the particular case, it is difficult to determine for yourself which is better to take, but in general, taking into account some factors, of these two substitutes, dydrogesterone is better. It is easier to tolerate, since it does not carry hormonal pressure on physiology. But this feature of it has one minus. For all his overwhelming positivity, you will have to pay 5 times more than for Norkolut, so if you are prescribed a short course of treatment, then it is better, of course, to buy the latter. In any case, without a doctor’s decision, based on the individual nuances of your body’s constitution, you should not prescribe treatment for yourself. The risks are too high. Please do not be silly and not sick at all!

A gynecological disorder, which is accompanied by the loss of natural progesterone – a hormone that affects the reproductive processes in a woman’s body – requires a special set of procedures based on the replacement of natural hormones with artificial ones. Part of this complex is the administration of drugs such as: Norkolut or Dufaston. The medical similarity of progesterone, the face of which these substitutes are, very fruitfully affects the reproductive organs.

pharmachologic effect

It provokes the modification of the uterus from the stage of cell multiplication to the stage of secretion isolation, blocks the secretion of gonadotropin in the pituitary gland, inhibiting the growth of follicles and the exit of the egg from the ovary into the fallopian tube.


Side effect

Migraine, tension of the mammary glands of external secretion, nausea, vomiting, blood from the vagina, disorder of tactile receptors, a sharp set of splendor of the body, asthenia, edema of the extremities, allergy. With prolonged use – thrombosis.

Contraindications for use:

  • Puberty.
  • MF cancer.
  • Genital tumors.
  • Pregnancy.
  • Jaundice.
  • Hepatic ailments.
  • Increased bilirubin concentration.
  • The tendency to thrombosis.
  • Bleeding from the vagina.
  • Obesity.
  • Herpes.
  • Hypersensitivity to the elements of the drug.

It is not scary if you accidentally took the drug at the beginning of the fetal ripening period. Norkolut will not affect, but, it is better to discontinue use.

After childbirth, it is also better not to take it, because both the qualitative and quantitative levels of milk are reduced.

special instructions

Before starting use, it is better to diagnose the body for malignant tumors.

If you forgot to take the drug, then immediately take it. It does not affect the ability to drive a car. An overdose is accompanied by: vomiting, vaginal bleeding.

Drug interaction

Liver enzymes accelerate the conversion of norethisterone. It is extremely prudent to use concurrently with glucose-lowering drugs, blood clots, glucocorticosteroids.

It is not advisable to “mix” with drugs that affect microsomal oxidation in the liver.


The active substance leading the composition of Duphaston, dydrogesterone, competes with norethisterone, also being an artificial substitute for progesterone. Dydrogesterone promotes the entry into force of the secretory phase in the inner layer of the uterus, thereby mitigating the risk of increased endometrial neoplasm caused by estrogens. Dydrogesterone does not prevent pregnancy.



Diseases provoked by a lack of progesterone:

  1. The proliferation of endometrial cells (the internal cavity of the uterus).
  2. Sterility (infertility).
  3. Risk of miscarriage.
  4. ICP.
  5. Pain in the lower abdomen during the menstrual cycle.
  6. Failure of the systematics of menstruation.
  7. The absence of menstruation.
  8. Hemorrhage from the uterus.

In case of accidental omission of the medication, it is necessary to fill this gap as soon as possible. This is fraught with the resumption of bleeding.

Side effect

Studies show that misuse of Duphaston leads to the following consequences:

  • Pain in the head.
  • Vomiting
  • Menstrual cycle failure.
  • Acute sensitivity of the mammary glands.
  • The destruction of red blood cells.
  • Depression.
  • Hypersensitivity.
  • Drowsiness.
  • Asthenia.
  • Quincke’s edema.

There is a chance of inhibition of pregnancy.

  1. Individual intolerance.
  2. Meningioma
  3. Vaginal bleeding of unknown origin.
  4. Hepatic Disorders
  5. Breast-feeding.
  6. Disorder of pigment exchange.
  7. Miscarriage.

There are too few cases of overdose to determine the limits of acceptability. Presumably overdose can be diagnosed by the following sensations: vomiting, drowsiness, dizziness. There is no antidote, therefore, rehabilitation is only necessary after consultation with a doctor.

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