Both have one active substance, which means they have one effect on the body during the treatment of hypertension. Hence some side effects and symptoms of an overdose. Indications and contraindications are also similar.
First of all, by the manufacturer, it means that the price will differ, depending on the place of residence. Some additional substances do not match.
The appearance and shape of the tablets also have significant differences. But this does not affect the therapeutic effect.
Who is the one and the other drug?
Both drugs will help patients with a history of:
- Stagnant CH.
- Bronchospastic conditions.
- Arterial hypertension of various forms (renovascular, resistant to other drugs for pressure).
- Ischemic heart disease.
Do not administer therapy to patients with:
- Hypersensitivity to substances in the composition.
- Angioneurotic, idiomatic edema.
- Renal artery stenosis, mitral valve.
- Renal failure.
Never appoint pregnant, lactating and pediatric patients up to 12 years.
As you can see, both drugs are strong in the correction of blood pressure, but which one will be prescribed depends on the patient’s place of residence, doctor’s recommendations and patient’s decision.
Blood pressure indicators can fluctuate during the day in insignificant numbers. If they exceed the permissible norm, this indicates pathological changes in the body that require treatment.
In the complex of symptomatic therapy, antihypertensive drugs are prescribed . Enalapril FPO is an effective and popular drug. There is another option – enalapril.
Enalapril-FPO
Producer: JSC Obolensk Pharmaceutical Enterprise Russia.
The drug is available in tablet form. Each unit contains 5/10/20 mg of the main substance – enalapril and excipients. Some of them: potato starch, milk sugar.
The tablet is flat-cylindrical, white with yellow.
The drug belongs to the group of ACE blockers. Therapeutic effect is achieved by reducing the formation of angiotensin | angiotensin ||, and this inhibits the secretion of aldosterone. Indicators of systolic, diastolic pressure, OPSS, post / preload on the myocardium are significantly reduced.
The main substance affects arteries rather than veins, expanding them. An increase in heart rate does not occur. The level of bradykinin rises. Increased Pg synthesis. The presence of renin in plasma affects the decrease in pressure. The higher its concentration, the more pronounced the hypotensive effect.
Therapeutic doses of the drug do not alter cerebral circulation. Blood flow in the coronary and renal vessels increases. Long-term drug therapy reduces hypertrophy of the left ventricle of the myocardium, muscle fibers of the arterial walls. Improves blood circulation of ischemic myocardial sites.
The risk of blood clots is reduced, which means that life is prolonged in patients with heart failure. In patients who have undergone myocardial infarction, the pathological change in LV is slowed down.
Enalapril acts as a diuretic. Reduces intracranial hypertension, inhibits the occurrence of glomerulosclerosis, chronic renal failure.
Enalapril-FPO is prescribed for oral use, regardless of food intake. Pressure decreases in an hour. Saved a day.
Absorbed up to 60% of the substance. Metabolism is carried out in the liver. It is excreted by the kidneys, intestines.
In cases of monotherapy, the initial dose consists of 5 mg / day. To achieve a clinical effect, an increase of 5 mg is possible (after 1-2 weeks). Given good tolerance, 40 mg / day are indicated in several doses. After 3 weeks, a maintenance dose is recommended: 10-40 mg / day in two divided doses.
This is not to say that the drug does not cause side effects. They affect many life systems:
- CCC: a strong decrease in blood pressure; collapse orthostatic; chest pain, angina pectoris, MI, arrhythmia, palpitations, fainting (rare).
- CNS: headache with impaired coordination of movement; fatigue with severe weakness; anxiety, insomnia, blurred consciousness.
- Sense organs: hearing loss, vision, vestibular apparatus.
- Gastrointestinal tract: refusal of food, dyspeptic disorders, disturbances in the liver, bile, pancreas.
- Respiratory system: spasm in the bronchi, shortness of breath, cough.
- Immune system: allergic rash; swelling of the face, lips, limbs, tongue, larynx; itching, urticaria.
It is important to adhere to the prescribed dosage of the drug, otherwise it may occur: a sharp decrease in blood pressure, leading to collapse; MI, acute cerebrovascular accident; complications associated with the formation of blood clots; convulsive conditions.
In case of symptoms, the patient must be moved to a lying position, legs raised in an upright position. Rinse the stomach, give hot, strong tea (a mild form of an overdose). Severe cases require hospitalization. There they will prescribe the introduction of a solution of sodium chloride and they will pick up symptomatic treatment.
Enalapril
Manufacturer Kievmedpreparat Ukraine. Available in tablet form. Each unit contains 10/20 mg of enalapril – a salt of maleic acid. It is supplemented with lactose monohydrate, corn starch and other chemicals.
Round tablets with a bevel and a print of “10” / “20 ″ (on the one hand), depending on the dosage of the main substance. They look white. The drug is classified as an ACE inhibitor.
Assign orally regardless of food intake. Adults with hypertension are shown 10 or 20 mg / day. With insufficient effectiveness, the attending physician adjusts the dosage to 40 mg / day. In the renovascular form, the initial dose is 5 mg / bitch and is adjusted to 20 mg. Therapy of HF: from 2.5 mg to 20 mg / day in two divided doses. The term of treatment is determined by the doctor.
It is important to know that in the case of a marked decrease in blood pressure, it is necessary to cancel the drug gradually, reducing the dosage.
Enalapril is used both in monotherapy and in complex treatment.
