Zinnat is a modern effective antibiotic assignable in a number of serious infectious diseases. BOS is characterized by a broad spectrum of activity against a number of representatives of pathogenic microflora. It refers to the clinico-pharmacological group of cephalosporins of the II generation.
The primary ingredient of Zinnat and method of production
Antibacterial agent is produced in tablets for receiving per os, as well as in the form of granules. The active ingredient – cefuroxime. The composition of 1 tablet included 125 or 250 mg active ingredient; they are supplied in packs of 5 or 10 pieces.
In the bottle there is 125 mg of cefuroxime in granules (bred to a volume of 5 ml). Capacity is equipped with spoons and cups for accurate dosage.
It is important
One of the supporting ingredients of the suspension is a sucrose that it is necessary to take into account patients suffering from diabetes.
Pharmacological properties Zinnat
Bacteriostatic and bactericidal properties Zinnat is due to inhibition of synthesis of components of the cell membrane of pathogenic bacteria. BOS is active in respect of a substantial part of the microorganisms that synthesize beta-lactamases.
Zinnat exhibits a pronounced bacteriostatic and bactericidal activity against gram-positive bacteria, aerobic, including some penicillin-resistant strains of gram-negative bacteria (including beta-hemolytic streptococci), as well as a number of anaerobes.
The antibiotic cephalosporin, is rapidly absorbed in the digestive tract, evenly spread in the body tissues through the blood. Plasma albumin anywhereelse to 50% of antibiotic. The highest content in the serum is fixed to normal after 2-3 hours after ingestion. Zinnat penetrates through gematoplatzentarnyi barrier and is found in breast milk and what to consider in the appointment of cyclosporine pregnant women and nursing mothers. In patients with meningitis in the cerebrospinal fluid is achieved therapeutic concentration. Drugs excreted by the kidneys in unchanged form. The half-life time under normal kidney function is 1-1.5 hours
Zinnat is indicated for the following infectious diseases:
Zinnat on readings assigned in such difficult conditions like sepsis (blood poisoning), peritonitis and meningitis.
Zinnat is absolutely contraindicated in patients with diagnosed hypersensitivity to cefuroxime and (or) auxiliary ingredients of the drug, and the antibiotic penicillin in history. Contraindications are bleeding and pathologies of the bowel (including ulcerative colitis).
An antibiotic is not prescribed to kids the first 3 months of life.
The dosage regimen
This drug is advisable to drink during a meal or directly after it, for faster and more complete absorption. Individual dosage depends on the nature of the disease, patient’s General condition and the dynamics of the pathological process.
Young children difficult to swallow pills, so they give the antibiotics in the form of a suspension. Upon dissolution of the granules in water for injection is formed of an opaque liquid with a pleasant aroma.
The average length of treatment Zinnat is 7 days.
In the treatment of infectious diseases of the lower respiratory system average weight for adults is usually administered as 250 mg, for children from 3 months. up to six months – 40-60 mg, for babies from 6 months. up to 2 years 60 to 120 mg, and young patients 2 to 12 years – 125 mg., the reception Frequency in each case 2 times per day.
Infectious diseases of the lower respiratory system, otitis media require the appointment of 500 mg for adults 60-90 mg kids from 3 to 6 months, 90-180 mg children from six months to 2 years 180-250 mg children 2 to 12 years. The reception frequency is 2 times per day.
Lyme disease (tick-borne borelliosis) adults and children under 12 years of age, it is recommended to take 500 mg 2 times a day for 20 days.
Infections of the genitourinary system involve receiving 125 mg 2 times a day. When diagnosed with pyelonephritis-time and daily dosage is doubled.
It is important
Therapy of gonorrhea (absence of complications) involves a single dose of 1 g Zinnat.
Hypersensitive to cephalosporins 2nd generation is not excluded allergic reactions in the form of urticaria, bronchospasm, angioneurotic edema and anaphylactic shock.
Among the other side effects are:
In the study of General blood analysis can detect leukopenia, eosinophilia, hemolytic anemia, and thrombocytopenia.
In case of accidental exceeding of the prescribed doses possible convulsions and Central nervous system excitation. A specific antidote has not yet been developed. Victim symptomatic treatment, as well as hardware cleansing blood through hemodialysis.
It is important
With the development of diarrhea on the background of Zinnat assume the possibility of development of pseudomembranous colitis.
Zinnat during pregnancy and lactation
Data about embriotoksicescoe and teratogenic effects of cefuroxime on the fetus are still insufficient, as no specific clinical studies have not been conducted. Women in period of gestation is strongly recommended to refrain from taking the drug in the first trimester, when there is a bookmark of organs of the child. On nursing a toddler, it is advisable to temporarily transfer to artificial feeding, because cefuroxime is found in breast milk.
Reactions with other drugs
Zinnat is able to provoke intestinal dysbiosis and reduce the natural biosynthesis of vitamin K.
Simultaneous consumption of antibiotics and so-called “loop diuretics” increase the risk of toxic effects on the kidneys.
Taking NSAIDs (including acetylsalicylic acid) and other drugs that can reduce blood clotting, increases the risk of bleeding.
Compatibility of Zinnat with alcohol
Zinnat and other antibiotics are absolutely incompatible with alcohol. At the same time strictly forbidden to take Zinnat and drinks containing ethyl alcohol (including pharmacy tincture) to avoid disulfiramopodobna effect (a sharp decline in pressure, redness of the face, tachycardia, etc.).
Storage conditions and supply of pharmacies
Antibacterial agent should be stored at temperatures not exceeding +25° C.
Shelf life – 36 months from the date specified on the original packaging.
The prepared suspension is allowed to keep in the refrigerator for 10 days (without freezing). If it is further diluted fruit drink, give her the child once.
Keep away from children!
Analogs for the active substance and the therapeutic effect are:
Plisov Vladimir, doctor, medical commentator